When submitting his script to studios, screenwriter Adam Herz titled it, "Untitled Teenage Sex Comedy That Can Be Made For Under $10 Million That Most Readers Will Probably Hate But I Think You Will Love". It was later changed to "East Great Falls High", then "Great Falls", and finally, "American Pie".
Alyson Hannigan went to her callback audition really having to pee. She ran to the bathroom and her name was called right after she got out. She went in without having calmed down so she read the part really quirky and with an over amount of energy. She credits that to her getting the part.
When Jim was running down the road to get to his house, Jason Biggs got heatstroke. They had to pack his shirt with ice to cool him down while he was running. Afterwards, they rushed him to a doctor. In another incident, while at home Jason Biggs also took too many Zinc supplements and became ill, so Jim was completely written out of the scene where Kevin and Finch are talking to each other while Finch is playing golf.
The URL for the webcam broadcast that Jim emails (from firstname.lastname@example.org) to his friends is http://22.214.171.124/temp/NadiaVision. (The IP address actually belongs to the Department of Psychology of the Johns Hopkins University in Baltimore, MD.)
Adam Herz's High School (and the one upon which he based East Great Falls High) was East Grand Rapids High. Yesterdog is the real name of the hot-dog "hang-out spot" for many of the real-life students.
In the scene where Kevin is watching Finch play golf, the scene was supposed to feature Jim as well. But the morning of the shoot, Jason Biggs felt ill and took too much zinc. The medics on set wound up calling poison control and nursing him back to health. The scene had to be shot without him and his lines were given to Kevin.
The part when Jessica and Vicky are reading the Spanish work and Jessica says, "Is this right, "go away, you stupid bird teacher, I had enough" was an inside joke from writer Adam Herz when he was in high school.