When submitting his script to studios, screenwriter Adam Herz titled it, "Untitled Teenage Sex Comedy That Can Be Made For Under $10 Million That Most Readers Will Probably Hate But I Think You Will Love". It was later changed to "East Great Falls High", then "Great Falls", and finally, "American Pie".
Alyson Hannigan went to her callback audition really having to pee. She ran to the bathroom and her name was called right after she got out. She went in without having calmed down so she read the part really quirky and with an over amount of energy. She credits that to her getting the part.
When Jim was running down the road to get to his house, Jason Biggs got heatstroke. They had to pack his shirt with ice to cool him down while he was running. Afterwards, they rushed him to a doctor. In another incident, while at home Jason Biggs also took too many Zinc supplements and became ill, so Jim was completely written out of the scene where Kevin and Finch are talking to each other while Finch is playing golf.
Was, alongside South Park: Bigger, longer and uncut, one of two explicit films released on the summer of 1999, with the highest number of reports of underage fans engaging in unsuccessful attempts to gain entrance and watch the film on theaters.
Adam Herz's High School (and the one upon which he based East Great Falls High) was East Grand Rapids High. Yesterdog is the real name of the hot-dog "hang-out spot" for many of the real-life students.
Eugene Levy was told he could improvise much of the dialogue for his character, including the part when flipping through the pornographic magazines with Jim, forcing a noticeably muffled laugh from Jason Biggs with the "giant orgy" line.
The URL for the webcam broadcast that Jim emails (from firstname.lastname@example.org) to his friends is http://126.96.36.199/temp/NadiaVision. (The IP address actually belongs to the Department of Psychology of the Johns Hopkins University in Baltimore, MD.)
The part when Jessica and Vicky are reading the Spanish work and Jessica says, "Is this right, "go away, you stupid bird teacher, I had enough" was an inside joke from writer Adam Herz when he was in high school.
The Scene in which Finch's scooter breaks down in front of Dog Years hot dog shop was unplanned. Director's Pete and Chris Weinz thought the scene was funny so they decided to leave it in the final cut of the film.
When Eugene Levy auditioned for this film, it's title was "East Great Falls High" and he was already shooting an independent film titled "American Pie". The indie had to change it's name to "The Secret Life of Girls".