The culmination of eight seasons ends tonight with a one-hour series finale. Will Will and Grace raise a child together and find ultimate happiness? Will Jack find anyone that loves him as much as he loves himself? Will...
When Will, Grace, Jack, and Karen want to spend Thanksgiving together. But they each have to visit someone or go to another Thanksgiving dinner. So Will comes up with the plan to visit each place for one hour at a time. But each visit leaves them reeling and leaves them unable to enjoy their own celebration.
Karen buys a horse in order to make money off of its use as a stud. Will & Grace see Will's dad's mistress Tina at a record store. George has opted to spend time with his wife instead of Tina, which had left Tina quite upset. Grace says she knows a right man for Tina. The only problem: even Grace does not know his identity yet.
Grace, while visiting Karen's husband in jail, is reunited with a high school friend. Ignoring Will's advice, she's visiting the inmate and dreaming of a life together outside the Big House. Rosario fusses at Karen for not being supportive of her incarcerated husband and bets Karen that she and Jack cannot stay together in the same room for three days without leaving or hurting each other.
Grace decides to accept the invitation to her ex-boyfriend's wedding and takes Will as her "plus one". What is Will going to say when people ask him to tell about himself? Jack has an argument with Bonnie about parenting their son.
It's the wedding anniversary of Will's parents. Will and Grace have a dinner with them in a restaurant. Will's father seems excited by his wife again and Will suspects that his father does not have a lover anymore. Will gives his father cruise tickets for an anniversary cruise and learns that Tina is still very much his father's lover. Meanwhile, Karen and Jack are climbing the stairs from street level to the 65th floor because Karen has a mental trauma involving an incident in the elevator.
It's Grace's first day teaching at a design seminar. She has asked Karen to be her assistant. Jack has a favor to ask from Will. Elliott has a basketball tournament where everyone's dad is attending, but Jack has duties he can't get away from. Will agrees to take his place.
Will's friend needs someone to plan his wedding. Grace takes the task upon herself but gets a bit carried away... Will and Karen discover they share a common passion: the book they are reading. Jack feels left out and starts acting jealously.
When Will's laptop computer is stolen, a detective takes Will's statement and discovers he's gay. Later he calls Will and asks him to participate in an operation to locate a gang of gay laptop thieves. Will agrees and they go to a gay bar. What Will doesn't know is that the man is still in the closet and does all sorts schemes, like what he did to Will, to get gay men to go out with him. Grace has to deal with Val who is trying to be a designer and she does so by getting Grace's ideas and clients.
Jack has news: his new show is about to open and this year his show features magic. He decides to ask Karen to be his assistant - a disaster in the making... Will has just won a photo session with the famous Fannie Lieber in a silent auction. The picture is going to appear in her next coffee table book. And Will asks Grace, who's a huge fan of Fannie's, to come with him to the session. What could possibly go wrong?
Will, Grace, Karen & Jack decide that they will do the one thing they should do before dying: Grace will train and run a marathon, Karen will make a conjugal visit to Stan in the prison, Jack will audition for a Broadway play and... Will wants to have a baby with Grace?
Will and Grace actually consider having sex together in order to get Grace pregnant. Karen meets someone who mistakes her for a high class prostitute. Jack considers quitting show business. Perhaps a divine intervention is needed?