Fry and Bender compete to see who can get the most fans on their Twitter-like application on their new eyePhones, not knowing that it's actually part of Mom's evil conspiracy to unleash a new virus on people's brains.
The professor is bored being old and decides to switch bodies with his intern, Amy. When they get tired of the game they decide to switch back, only to discover its not possible to swap with the same person twice. Bender agrees to swap between them to get everyone back in order, but only after he commits the perfect crime.
Lurrr and his wife can't make their relationship work, so she kicks him out of the house. He moves in with Leela as she's the only non-omicronian he knows. To get him off the couch they hatch a plan to appear as if he's taken over Earth. Things get out of hand when the wife as well as Earths Defense Force believe he's actually done it.
Fry accidentally reveals that Leela is a mutant, so she is banished to the sewers where all mutants must live. Not willing to accept this, Leela and Fry organize the mutant uprising against this segregation.
Three separate holiday stories: X-mas, Robanaca and Kwanzaa. 1. Once more Robot Santa comes to town. Besides the violence he spreads, this time he sings to the crew of the pine tree that are needed for a proper "X-mas". The only problem is that the pine trees have been extinct for over 800 years. However they manage to get some seeds, reforesting the earth. As the oxygen levels explode Bender causes the whole earth to catch fire. 2. Several weeks later, out of laziness Bender insists on celebrating the fake "Robanaca". For the traditional oil wrestling he needs ...
Fry believes that a human life is more important than a robot life, so Bender decides to kill himself again, only this time he really follows through. But instead of dying he turns into a ghost that haunts Fry.
The episode contains three separate stories. In the first, which parodies the 1930s B&W cartoons, Fry wants to propose to Leela, so he blows up a comet made of "dimondium" to make her a diamond ring. In the second, which parodies the 1980s video games, the Professor invents a microscope with an infinite magnification and learns all the secrets of the Universe, which puts him and other scientists out of business. In the third part, which parodies Japanese anime, the team must defend Earth from dancing aliens.