The episode traces the history of the electric guitar sound that emanated from it's roots in country Western, rockabilly, and the blues, and how living legends like Eric Clapton, Jimmy Page, Jeff Back, Keith Richards and Bono developed their own particular signatures, so that anyone hearing them play might immediately know who it was without seeing them. It was particularly amusing to hear Pete Townshend reminisce, expressing his concern to Eric Clapton about this new guy Hendrix who was going to put them all out of business with the way he played.
Another amusing mention was made of Guns 'n' Roses guitarist Slash, who's style of holding his guitar directly corresponded to a certain portion of the male anatomy. Additional commentary pursued this line of male sexuality and the way it was expressed through music, an idea reinforced by the many groupies who followed these popular artists around from venue to venue. Virtually all took advantage, though Steven Tyler of Aerosmith did admit that he missed out on a lot of sex by being too stoned out on drugs and alcohol most of the time. Hearing him speak like that, it sounded like he learned his lesson.