During filming, Robin Williams and the rest of the cast and crew worked closely with the Make-A-Wish Foundation to fulfill the fantasies of several children who were at the time undergoing cancer treatment. The children appeared with Williams in scenes at the pediatric ward.
One of the film's producers, Mike Farrell, met the real Patch Adams when Adams served as an advisor to the TV series M*A*S*H, in which Farrell played, B.J. Hunnicutt, one of the Army doctors.
When Dean Walcott is walking down the hall, right before he enters the room where Patch is playing with the hospital bed, there is a page that comes over the intercom for Dr. Maslow to dial 214. Dr. Abraham Maslow, noted psychologist, developed the "Hierarchy of Needs" that explains how the personality reacts to environmental factors and needs.