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Patch's (Robin Williams) roommate in the mental hospital is played by Michael Jeter. In The Fisher King, Jeter also played an insane companion of Williams'.
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During filming, Robin Williams and the rest of the cast and crew worked closely with the Make-A-Wish Foundation to fulfill the fantasies of several children who were at the time undergoing cancer treatment. The children appeared with Williams in scenes at the pediatric ward.
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One of the film's producers, Mike Farrell, met the real Patch Adams when Adams served as an advisor to the TV series M*A*S*H, in which Farrell played, B.J. Hunnicutt, one of the Army doctors.
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The poem that Patch reads to Corinne is an English translation of "Sonnet XVII" by Pablo Neruda.
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The song "Faith of the Heart" performed in this film by Rod Stewart, was later used as theme song of Star Trek: Enterprise.
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Richard Kiley's final film.
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When Dean Walcott is walking down the hall, right before he enters the room where Patch is playing with the hospital bed, there is a page that comes over the intercom for Dr. Maslow to dial 214. Dr. Abraham Maslow, noted psychologist, developed the "Hierarchy of Needs" that explains how the personality reacts to environmental factors and needs.
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Filmed partially at the University of North Carolina. Robin Williams did stand up comedy for some classes that were in session while filming.
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While the real Patch Adams made a brief cameo in the film, he "hated" the film and the portrayal of himself.
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Cameo 

Patch Adams:  The real Patch Adams appears in the scene where the medical school staff returns with the verdict. He sits right behind Robin Williams.
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Spoilers 

The trivia items below may give away important plot points.

In real life, Patch's close friend who was murdered was a man, not a female love interest. Carin is a fictional character.
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