After an incident where Renee fails to save a mother from an Atavus attack, she suffers PTSD and needs a break. She and Street head to a spa, but when Renee claims to have seen an Atavus, Street believes she's just being paranoid.
Renee is suspicious when a friend's wife and other patients become comatose supposedly from allergic reactions to anesthesia. She suspects Sandoval when she sees hybrids at the hospital. She needs an Atavus blood sample to find an antidote.
Renee and Sandoval stand off at a hive where an adult Atavus is killed, but Renee takes a young one back to Street. Howlyn commands Sandoval to find and kill the youth who turns out to be Howlyn's son.
Patrichio is broken out of jail, tried, and killed by a vigilante group called the "Preservationists" protesting the government's stance on the Atavus. Their next target is Renee. She chooses Michaels as her lawyer for the vigilante trial.
Renee and Michaels take one of his men to the hospital to receive the hybrid vaccination, but Michaels suspects something strange is going on. Ra'jel visits Renee to prepare her for the final conflict.