Renee has spent company money and time on a search and rescue team to discover what happened to Liam in the chamber. She is asked to cease or quit. She quits, convinced that Liam is alive. Street helps her put together a new search team.
On the mother ship, Sandoval tries to deal with the Atavus to preserve himself. Renee wants to act, tries to convince Hubble that the Atavus exist and need to be terminated. Street doesn't trust Hubble and thinks they should just lay low.
Renee is still having trouble getting anyone to believe her about the Atavus. She meets a man who tells her that people who live underground are disappearing, due to the Atavus. They find a chamber used to make hybrids.
Renee has crystal that shows a map of where all the other Atavus hives are throughout the planet. She goes to Boone for help in destroying the hives before Howlyn can find them. Sandoval resurrects Zo'or to hunt Boone.
From a hive under Stonehenge, Renee and Street take an Atavus called Gren in his stasis chamber to the Antarctic to see if the cold will affect him. Gren tries to convince Street that most Atavus are peaceful and will not feed from humans.
After an incident where Renee fails to save a mother from an Atavus attack, she suffers PTSD and needs a break. She and Street head to a spa, but when Renee claims to have seen an Atavus, Street believes she's just being paranoid.
Renee is suspicious when a friend's wife and other patients become comatose supposedly from allergic reactions to anesthesia. She suspects Sandoval when she sees hybrids at the hospital. She needs an Atavus blood sample to find an antidote.
Renee and Sandoval stand off at a hive where an adult Atavus is killed, but Renee takes a young one back to Street. Howlyn commands Sandoval to find and kill the youth who turns out to be Howlyn's son.
Patrichio is broken out of jail, tried, and killed by a vigilante group called the "Preservationists" protesting the government's stance on the Atavus. Their next target is Renee. She chooses Michaels as her lawyer for the vigilante trial.
Renee and Michaels take one of his men to the hospital to receive the hybrid vaccination, but Michaels suspects something strange is going on. Ra'jel visits Renee to prepare her for the final conflict.