
| Andrew Rooney | ... | Himself - Commentator (segment "Andy Rooney") / ... (342 episodes, 1978-2011) |
 | Lesley Stahl | ... | Herself - Host / ... (285 episodes, 1991-2013) |

| Steve Kroft | ... | Himself - Host / ... (274 episodes, 1989-2013) |

| Scott Pelley | ... | Himself - Host / ... (258 episodes, 2003-2013) |

| Morley Safer | ... | Himself - Host / ... (212 episodes, 1970-2013) |

| Bob Simon | ... | Himself - Host / ... (172 episodes, 2003-2013) |
 | Ed Bradley | ... | Himself - Host / ... (112 episodes, 1981-2006) |

| Mike Wallace | ... | Himself - Host / ... (97 episodes, 1968-2008) |

| Lara Logan | ... | Herself - Correspondent / ... (61 episodes, 2005-2013) |

| Anderson Cooper | ... | Himself - Correspondent (segment "Michael Phelps") / ... (53 episodes, 2006-2013) |

| Katie Couric | ... | Herself - Host / ... (36 episodes, 2006-2011) |
 | Byron Pitts | ... | Himself - Correspondent (segment "Joel Osteen") / ... (35 episodes, 2006-2013) |

| Barack Obama | ... | Himself (segment "President Obama") / ... (16 episodes, 2007-2013) |
 | David Martin | ... | Himself - Correspondent (segment "Never Seen the Like") / ... (11 episodes, 2003-2013) |

| Dan Rather | ... | Himself - Correspondent / ... (10 episodes, 1975-2006) |
 | Harry Reasoner | ... | Himself - Correspondent / ... (9 episodes, 1968-1969) |

| Charlie Rose | ... | Himself - Correspondent (segment "Penelope Cruz") / ... (8 episodes, 2008-2013) |
 | Molly Ivins | ... | Herself - Commentator (segment "Ivins & Crouch, Crouch & Ivins") / ... (8 episodes, 1996) |

| Christiane Amanpour | ... | Herself - Correspondent (segment "Amazon Treasure") / ... (7 episodes, 2003-2005) |
 | Raymond W. Kelly | ... | Himself - New York City Police Commissioner (segment "Stop Snitchin'") / ... (6 episodes, 2005-2011) |

| Hillary Rodham Clinton | ... | Herself - Secretary of State (segment "President Obama & Secretary Clinton") / ... (5 episodes, 2008-2013) |

| Frank Partnoy | ... | Himself - Former Derivatives Trader (segment "Wall Street's Shadow Market") / ... (5 episodes, 2008-2012) |
 | Sanjay Gupta | ... | Himself - Correspondent (segment "Sugar") / ... (5 episodes, 2011-2012) |
 | David Axelrod | ... | Himself - Chief Strategist (segment "Obama '08") / ... (4 episodes, 2008-2009) |

| Arnold Schwarzenegger | ... | Himself (segment "Arnold") / ... (4 episodes, 2004-2012) |

| Armen Keteyian | ... | Himself - Correspondent (segment "The College Game") / ... (4 episodes, 2008-2012) |
 | Charles Grassley | ... | Himself - Chairman, Senate Finance Committee (segment "Gimme Shelter") / ... (4 episodes, 2003-2007) |

| John McCain | ... | Himself - Senator, Arizona (segment "In Harm's Way") / ... (4 episodes, 2004-2008) |

| Michael Bloomberg | ... | Himself - Mayor, New York (segment "The Billionaire") / ... (4 episodes, 2005-2011) |
 | Gustavo Dudamel | ... | Himself - Composder (segment "Update") / ... (4 episodes, 2008-2013) |

| Stanley Crouch | ... | Himself - Commentator (segment "Ivins & Crouch, Crouch & Ivins") / ... (4 episodes, 1996) |
 | P.J. O'Rourke | ... | Himself - Commentator (segment "O'Rourke & Ivins, Ivins & O'Rourke") / ... (4 episodes, 1996) |

| Mitt Romney | ... | Himself - Former Governor, Massachusetts / ... (3 episodes, 2007-2012) |
 | Michael Scheuer | ... | Himself - CIA Agent (segment "Bin Laden's Bodyguard") / ... (3 episodes, 2004-2006) |
 | Tyler Drumheller | ... | Himself - Former CIA Division Chief (segment "Curve Ball") / ... (3 episodes, 2006-2011) |

| Michelle Obama | ... | Herself - Barack Obama's Wife (segment "Barack Obama") / ... (3 episodes, 2007-2008) |
 | Hamid Karzai | ... | Himself - President, Afghanistan (segment "Addicted to Heroin") / ... (3 episodes, 2005-2012) |
 | Jim Grant | ... | Himself - Editor, Grant's Interest Rate Observer (segment "House of Cards") / ... (3 episodes, 2008) |
 | Michelle Wie | ... | Herself - Golf Prodigy / ... (3 episodes, 2004-2006) |
 | Robert Fein | ... | Himself - Assassination Expert (segment "Descent Into Madness") / ... (3 episodes, 2007-2012) |
 | Bryan Vossekuil | ... | Himself - Assassination Expert (segment "Descent Into Madness") / ... (3 episodes, 2007-2012) |

| Condoleezza Rice | ... | Herself - National Security Adviser (segment "Condoleezza Rice") / ... (3 episodes, 2004-2006) |

| Nancy Pelosi | ... | Herself - Representative, California (segment "The Bailout") / ... (3 episodes, 2006-2011) |

| Barney Frank | ... | Himself - Representative, Massachusetts (segment "A Bigger Leap for Mankind") / ... (3 episodes, 2008-2011) |
 | John Hawkins | ... | Himself - Golf World / ... (3 episodes, 2004-2006) |
 | Raymond Odierno | ... | Himself - General (segment "General O") / ... (3 episodes, 2008-2010) |
 | John Prendergast | ... | Himself - Former Director of African Affairs, National Security Council (segment "The Killing in Sudan") / ... (3 episodes, 2004-2009) |
 | Joseph Wilson | ... | Himself - Former Ambassador (segment "A Spy Speaks Out") / ... (3 episodes, 2005-2007) |
 | Pervez Musharraf | ... | Himself - President, Pakistan (segment "In Search of Bin Laden") / ... (3 episodes, 2005-2008) |
 | Mitch Landrieu | ... | Himself - Mayor of New Orleans (segment "The Paper") / ... (3 episodes, 2010-2013) |
 | Dan Burton | ... | Himself - Representative, Indiana (segment "Kidnapped") / ... (3 episodes, 2002-2007) |
 | David M. Walker | ... | Himself - Bank Manager (segment "Doing Business with the Enemy") / ... (3 episodes, 2004-2009) |

| Geoffrey Canada | ... | Himself - Anti-Violence Advocate (segment "Stop Snitchin'") / ... (3 episodes, 2006-2009) |
 | Eric Schmidt | ... | Himself - CEO, Google (segment "Google") / ... (3 episodes, 2005-2012) |
 | Michael Lewis | ... | Himself - Author, The Big Short: Inside the Doomsday Machine (segment "Inside the Collapse") / ... (3 episodes, 2009-2010) |
 | Kenneth Feinberg | ... | Himself - Attorney (segment "Mr. Feinberg") / ... (3 episodes, 2003-2010) |
 | Derek Paravicini | ... | Himself - Musical Savant (segment "Derek") / ... (3 episodes, 2003-2010) |

| Bill Clinton | ... | Himself - Former President (segment "Fighting AIDS") / ... (3 episodes, 2003-2010) |
 | Adam Ockelford | ... | Himself - Derek's Teacher (segment "Derek") / ... (3 episodes, 2003-2010) |
 | Rex Lewis-Clack | ... | Himself - Musical Savant (segment "Rex") / ... (3 episodes, 2003-2008) |
 | Cathleen Lewis | ... | Herself - Rex's Mother (segment "Rex") / ... (3 episodes, 2003-2008) |

| Howard Stringer | ... | Himself - CEO, Sony (segment "Sir Howard") / ... (3 episodes, 2006-2009) |
 | Harry Reid | ... | Himself - Democratic Majority Leader (segment "The Broken Senate") / ... (3 episodes, 2003-2012) |

| Jane Fonda | ... | Herself - Actress (segment "Jane Fonda: My Life So Far - Part I") / ... (3 episodes, 2005-2008) |

| Steven Spielberg | ... | Himself - Director (segment "Drew Barrymore") / ... (3 episodes, 2009-2013) |
 | Mike Rogers | ... | Himself - House Intelligence Committee (segment "Afghanistan's Top Spy") / ... (3 episodes, 2011-2012) |
 | John Edwards | ... | Himself / ... (3 episodes, 2003-2007) |

| Elizabeth Edwards | ... | Herself / ... (3 episodes, 2003-2007) |
 | Bob Woodward | ... | Himself - Author, Plan of Attack (segment "Plan of Attack") / ... (2 episodes, 2004-2006) |
 | Ahmad Chalabi | ... | Himself - Iraqi Exile (segment "The Blame Game") / ... (2 episodes, 2004-2005) |
 | Mahmoud Ahmadinejad | ... | Himself - President, Iran (segment "President Ahmadinejad") (2 episodes, 2006-2007) |
 | David Evans | ... | Himself - Duke Lacrosse Player (segment "Innocent") / ... (2 episodes, 2006-2007) |
 | Robert Gates | ... | Himself - Defense Secretary (segment "Secretary of War") / ... (2 episodes, 2009-2011) |
 | Ben Bernanke | ... | Himself (segment "The Chairman") / ... (2 episodes, 2009-2010) |
 | John Gotti Jr. | ... | Himself - John Gotti's Son / ... (2 episodes, 2010-2011) |
 | John Allen | ... | Himself - Commander, U.S. Forces Afghanistan (segment "The Longest War") / ... (2 episodes, 2011-2012) |
 | Anthony Casso | ... | Himself - Mobster (segment "Gangster Cops?") / ... (2 episodes, 2005-2006) |
 | Vincent Giordano | ... | Himself - Chief, NYPD (segment "Defending New York") / ... (2 episodes, 2006-2011) |
 | Radhi Al-Radhi | ... | Himself - Iraq's Top Anti-Corruption Official (segment "State of Corruption") / ... (2 episodes, 2006-2008) |

| Joe Biden | ... | Himself - Senator, Delaware (segment "Obama Biden '08") / ... (2 episodes, 2008-2009) |
 | Ray Nagin | ... | Himself - Mayor, New Orleans (segment "New Orleans") / ... (2 episodes, 2005-2006) |
 | Luke Duvall | ... | Himself - Patient (segment "H1N1 II") / ... (2 episodes, 2009) |
 | Doug Jones | ... | Himself - Siegelman's Lawyer (segment "The Prosecution of Governor Siegelman") / ... (2 episodes, 2003-2008) |
 | Basil Al-Saati | ... | Himself - Iraqi Scientist (segment "Curve Ball") (2 episodes, 2007-2011) |
 | Jim Lewis | ... | Himself - Director, Center for Strategic and International Studies (segment "Sabotaging the System") / ... (2 episodes, 2009-2012) |
 | Geoffrey Ling | ... | Himself - Neurologist & Army Colonel (segment "Breakthrough") / ... (2 episodes, 2009-2012) |
 | John Boehner | ... | Himself (segment "The Next Speaker") / ... (2 episodes, 2010-2011) |
 | Ziad Cattan | ... | Himself - Defense Minister Deputy (segment "The Mother of All Heists") / ... (2 episodes, 2006-2008) |
 | Collin Finnerty | ... | Himself - Duke Lacrosse Player (segment "Innocent") / ... (2 episodes, 2006-2007) |
 | Reade Seligmann | ... | Himself - Duke Lacrosse Player (segment "Innocent") / ... (2 episodes, 2006-2007) |
 | Ed Davis | ... | Himself - Boston Police Commissioner (segment "The Boston Bombings") / ... (2 episodes, 2009-2013) |
 | Charles Carnesi | ... | Himself - Lawyer / ... (2 episodes, 2010-2011) |
 | Edward Hayes | ... | Himself - Caracappa's Lawyer (segment "Gangster Cops?") / ... (2 episodes, 2005-2006) |
 | Saleh Al-Sheikh | ... | Himself - Minister of Islamic Affairs (segment "Breeding Ground") / ... (2 episodes, 2005) |
 | Malia Obama | ... | Herself - Daughter / ... (2 episodes, 2008) |

| James Brown | ... | Himself - Correspondent (segment "Blindsided") / ... (2 episodes, 2009-2013) |
 | Nora Volkow | ... | Herself - National Institute on Drug Abuse (segment "Hooked") / ... (2 episodes, 2010-2012) |

| Michael Greenberger | ... | Himself - Commodity Futures Trading Commission (segment "The Price of Oil") / ... (2 episodes, 2008-2009) |
 | Anneke Van Woudenberg | ... | Herself - Human Rights Watch (segment "Congo Gold") / ... (2 episodes, 2008-2009) |
 | Henry Crumpton | ... | Himself - Former CIA Officer (segment "Out of the Shadows") / ... (2 episodes, 2009-2012) |
 | Sheila Bair | ... | Herself - Chairman, FDIC (segment "Your Bank Has Failed") / ... (2 episodes, 2009-2011) |
 | David Raizk | ... | Himself - Mayor, Wilmington (segment "The Long Recession: Wilmington Corporation") / ... (2 episodes, 2009) |
 | Tyler Hamilton | ... | Himself - Cyclist (segment "Armstrong") / ... (2 episodes, 2011-2013) |
 | David Leadbetter | ... | Himself - Coach / ... (2 episodes, 2004-2005) |
 | David Plouffe | ... | Himself - Campaign Manager / ... (2 episodes, 2008) |
 | Belinda Duvall | ... | Herself - Luke's Mother (segment "H1N1 II") / ... (2 episodes, 2009) |

| Christine Lagarde | ... | Herself (segment "Christine Lagarde") / ... (2 episodes, 2011-2012) |
 | Loretta Sanchez | ... | Herself - Representative, California (segment "Death of a General") / ... (2 episodes, 2005-2006) |
 | T. Boone Pickens | ... | Himself (segment "T. Boone Pickens") / ... (2 episodes, 2006-2008) |

| Will Smith | ... | Himself (segment "Will Smith") / ... (2 episodes, 2007-2008) |
 | Oliver Thomas Jr. | ... | Himself - President, New Orleans City Council (segment "One Year Later") / ... (2 episodes, 2005-2006) |
 | Wayne Cornelius | ... | Himself - Professor, University of California, San Diego (segment "Watching the Border") / ... (2 episodes, 2005-2010) |
 | James McGaugh | ... | Himself - Professor of Neurobiology, University of California at Irvine (segment "Endless Memory") / ... (2 episodes, 2006-2010) |
 | Richar Anozier | ... | Himself - Darlene's Son (segment "The Harlem Children's Zone") / ... (2 episodes, 2006-2009) |
 | Kip Hawley | ... | Himself - Director, Transportation Security Administration (segment "The No-Fly List") / ... (2 episodes, 2006-2008) |
 | Garry Kasparov | ... | Himself - Chess Grandmaster & Activist (segment "The Match of His Life") / ... (2 episodes, 2007-2013) |
 | Cayetano Rivera Ordóñez | ... | Himself - Bull Fighter / ... (2 episodes, 2008-2010) |
 | Francisco Rivera Ordóñez | ... | Himself - Bull Fighter / ... (2 episodes, 2008-2010) |
 | Anita Dunn | ... | Herself - Obama's Campaign Team / ... (2 episodes, 2008) |
 | Amrullah Saleh | ... | Himself - Afghanistan Chief of Intelligence (segment "Afghanistan's Top Spy") / ... (2 episodes, 2009-2011) |
 | Carolyn Merritt | ... | Herself - Chemical Safety Board (segment "Combustible Dust") / ... (2 episodes, 2006-2008) |
 | Barry Scheck | ... | Himself - Director, Innocence Project (segment "Evidence of Injustice") / ... (2 episodes, 2007-2012) |
 | Vy Higginsen | ... | Herself - Mama Foundation (segment "Roots") / ... (2 episodes, 2007-2011) |
 | Beth Davalos | ... | Herself - Social Worker (segment "Hard Time Generation") / ... (2 episodes, 2011) |
 | Steve Kissinger | ... | Himself - Lawyer (segment "Insanity on Death Row") / ... (2 episodes, 2004-2007) |
 | George Tenet | ... | Himself - CIA Director (segment "Out of Control") / ... (2 episodes, 2004-2007) |
 | Christopher Cox | ... | Himself - Head of Product Development (segment "Facebook") / ... (2 episodes, 2005-2010) |
 | Don Siegelman | ... | Himself - Former Governor, Alabama (segment "The Prosecution of Governor Siegelman") / ... (2 episodes, 2008) |
 | Rick Wagoner | ... | Himself - Chairman, GM (segment "What's Good for America...") / ... (2 episodes, 2006) |

| Mark Zuckerberg | ... | Himself - Facebook Founder (segment "Facebook") / ... (2 episodes, 2008-2010) |
 | Hussein Shahristani | ... | Himself - Former Iraqi Exile (segment "Operation Iraqi Freedom?") / ... (2 episodes, 2003-2010) |
 | Robert Daum | ... | Himself - University of Chicago Children's Hospital (segment "Superbugs") / ... (2 episodes, 2004-2007) |
 | Ricky Williams | ... | Himself - NFL Player (segment "Ricky Williams Returns") / ... (2 episodes, 2004-2005) |
 | Lawrence Wilkerson | ... | Himself - Chief of Staff to Colin Powell (segment "Curve Ball") / ... (2 episodes, 2006-2007) |
 | Sean Henry | ... | Himself - Assistant Director, FBI (segment "Sabotaging the System") / ... (2 episodes, 2007-2009) |
 | Kathleen Rice | ... | Herself - District Attorney (segment "Is It Murder?") / ... (2 episodes, 2009-2012) |
 | Adel Al-Jubeir | ... | Himself - Foreign Affairs Adviser, Saudi Arabia (segment "Breeding Ground") / ... (2 episodes, 2002-2005) |
 | Dan Kammen | ... | Himself - Physicist (segment "Powered by Coal") / ... (2 episodes, 2006-2009) |
 | Kara Swisher | ... | Herself - Blogger, All Things Digital (segment "The Face Behind Facebook") / ... (2 episodes, 2008-2010) |
 | Jim Amoss | ... | Himself - Editor, New Orleans Times Picayune (segment "Bobby Jindal") / ... (2 episodes, 2009-2013) |
 | Margaret Hamburg | ... | Herself - Doctor (segment "Lethal Medicine") / ... (2 episodes, 2011-2013) |

| Leslie Moonves | ... | Himself - CBS President / ... (2 episodes, 2002-2009) |
 | Dale Johnson | ... | Himself - Father of Nicholas (segment "Superbug") / ... (2 episodes, 2004-2007) |
 | Mike Williams | ... | Himself - Deepwater Horizon Worker (segment "The Blowout") / ... (2 episodes, 2005-2010) |
 | John Kanzius | ... | Himself - Inventor (segment "The Kanzius Machine") (2 episodes, 2008-2009) |
 | David Stern | ... | Himself - Commissioner, NBA (segment "Linsanity") / ... (2 episodes, 2010-2013) |
 | Jay Greenberg | ... | Himself - Composer (segment "Bluejay") (2 episodes, 2004-2006) |
 | Jeffrey Smith | ... | Himself - Colonel (segment "The Sunni Triangle") / ... (2 episodes, 2004-2005) |
 | Chuck Schumer | ... | Himself - Senator, New York (segment "Judge Charles Pickering") / ... (2 episodes, 2004) |

| Bono | ... | Himself - Singer (segment "U2") / ... (2 episodes, 2005-2010) |
 | Jim O'Neill | ... | Himself - Bomb Squad Advisor (segment "Kathryn Bigelow") / ... (2 episodes, 2010-2012) |
 | Janet Johnson | ... | Herself - Mother of Nicholas (segment "Superbug") / ... (2 episodes, 2004-2007) |

| George Bush | ... | Himself - President (segment "Andy Rooney") / ... (2 episodes, 2007) |
 | Andy Schwartz | ... | Himself - Neuroscientist (segment "Brain Power") / ... (2 episodes, 2008-2012) |
 | Marianne Kanzius | ... | Herself - John's Wife (segment "The Kanzius Machine") (2 episodes, 2008-2009) |
 | Richard Leakey | ... | Himself - Conservationist (segment "Poisoned") / ... (2 episodes, 2009-2010) |
 | Jerry Jones | ... | Himself (segment "Jerry Jones") / ... (2 episodes, 2004-2010) |

| The Edge | ... | Himself - Guitarist (segment "U2") / ... (2 episodes, 2005-2010) |
 | Daniel Barenboim | ... | Himself - Conductor (segment "Gustavo the Great") / ... (2 episodes, 2005-2008) |
 | Bob Lutz | ... | Himself - Vice Chairman, General Motors Company (segment "What's Good for America...") / ... (2 episodes, 2006-2008) |
 | James Coleman | ... | Himself - Law Professor, Duke University (segment "The Duke Case") / ... (2 episodes, 2006-2007) |
 | Paul Farmer | ... | Himself - Haiti Relief Doctor (segment "Haiti") / ... (2 episodes, 2008-2010) |
 | Joe Carbone | ... | Himself - President, The Workplace (segment "Trapped in Unemployment") / ... (2 episodes, 2011-2012) |
 | Nicholas Johnson | ... | Himself - MRSA Survivor (segment "Superbug") / ... (2 episodes, 2004-2007) |
 | Samuel Zyman | ... | Himself - Jay's Teacher (segment "Bluejay") (2 episodes, 2004-2006) |

| David Smith | ... | Himself - Field Director, Earth Conservation Corps (segment "Endangered Species") / ... (2 episodes, 2005-2013) |
 | Theresa Vaughn | ... | Herself - Researcher (segment "Brain Power") / ... (2 episodes, 2007-2008) |
 | Steven Curley | ... | Himself - Cancer Surgeon (segment "The Kanzius Machine") / ... (2 episodes, 2008-2009) |
 | Anthony Fauci | ... | Himself - Institute of Allergy and Infectious Diseases (segment "Superbugs") / ... (2 episodes, 2004-2005) |
 | Mike Greenberg | ... | Himself - Former Project Manager (segment "Tunnel #3") / ... (2 episodes, 2004-2005) |
 | Richard Brodhead | ... | Himself - President, Duke University (segment "The Duke Case") / ... (2 episodes, 2006-2007) |
 | Pete Carroll | ... | Himself - Coach (segment "Coach Carroll") / ... (2 episodes, 2008-2013) |

| James Cameron | ... | Himself (segment "Cameron's Avatar") / ... (2 episodes, 2009-2010) |
 | Tim Johnson | ... | Himself - Marfa Poet (segment "Marfa, Texas") / ... (2 episodes, 2011-2013) |
 | Richard McBrien | ... | Himself - Author, The Lives of the Saints (segment "Sainthood") / ... (2 episodes, 2003-2005) |
 | Spencer Abraham | ... | Himself - Energy Department (segment "How Many Miles to the Gallon?") / ... (2 episodes, 2003) |
 | David Kessler | ... | Himself - Former FDA Commissioner (segment "Lethal Medicine") / ... (2 episodes, 2011-2013) |

| Christopher Hitchens | ... | Himself (segment "Hitchens") / ... (2 episodes, 2003-2011) |
 | George Anastasia | ... | Himself - Author, The Last Gangster (segment "The Last Gangster") / ... (2 episodes, 2004-2013) |
 | Valery Gergiev | ... | Himself - Conductor (segment "The Wild Man of Music") / ... (2 episodes, 2004) |
 | James Hansen | ... | Himself - Climate Scienist, NASA (segment "Powered by Coal") / ... (2 episodes, 2006-2009) |
 | Sean Carroll | ... | Himself - Professor of Molecular Biology (segment "B-Rex") / ... (2 episodes, 2009-2010) |

| Howard Stern | ... | Himself - Radio Host (segment "Dog Nut") / ... (2 episodes, 2005-2007) |
 | Thomas Frieden | ... | Himself - Director of the CDC (segment "H1N1") / ... (2 episodes, 2007-2009) |

| Tina Fey | ... | Herself - Actress (segment "Alec Baldwin") / ... (2 episodes, 2004-2008) |
 | Art Kaplan | ... | Himself - Bioethicist, University of Pennsylvania (segment "A Surplus of Embryos") / ... (2 episodes, 2004-2006) |
 | John Allen | ... | Himself - National Catholic Reporter (segment "Sainthood") / ... (2 episodes, 2003-2011) |

| Jon Stewart | ... | Himself - Host, The Daily Show (segment "B.S. Rules!") / ... (2 episodes, 2004-2005) |
 | Sara Banta | ... | Herself - Rex's Piano Teacher (segment "Rex") (2 episodes, 2005-2008) |

| Dustin Hoffman | ... | Himself - Actor (segment "Dame Maggie") / ... (2 episodes, 2004-2013) |
 | Michael H. Gavshon | ... | Himself - Producer (segment "Swimming with Sharks") / ... (2 episodes, 2005-2008) |
 | David Pinto | ... | Himself - Music Teacher for the Blind (segment "Rex") (2 episodes, 2005-2008) |
 | Charlie Weis | ... | Himself - Former Offensive Coordinator, New England Patriots (segment "The Winner") / ... (2 episodes, 2005-2006) |

| Michael Phelps | ... | Himself (segment "Michael Phelps") (2 episodes, 2008-2012) |
 | Paul Mayewski | ... | Himself - Climate Change Institute (segment "The Age of Warming") / ... (2 episodes, 2006-2007) |
 | David McCullough | ... | Himself - Historian (segment "McCullough") (2 episodes, 2012) |
 | Rachel Flowers | ... | Herself - Blind Musician (segment "Rex") / ... (2 episodes, 2005-2008) |
 | Bob Bowman | ... | Himself - Michael's Coach (segment "Michael Phelps") (2 episodes, 2008-2012) |

| Wynton Marsalis | ... | Himself (segment "Wynton") / ... (2 episodes, 2006-2011) |
 | David Walton | ... | Himself - Doctor (segment "Dr. Farmer's Remedy") / ... (2 episodes, 2008-2010) |
 | Debbie Phelps | ... | Herself - Michael's Mother (segment "Michael Phelps") (2 episodes, 2008-2012) |
 | Freddy Adu | ... | Himself - Soccer Player (segment "Freddy Adu") / ... (2 episodes, 2004-2005) |
 | Bruce Arena | ... | Himself - Coach / ... (2 episodes, 2004-2005) |

| John Kerry | ... | Himself / ... (2 episodes, 2004) |
 | Teresa Heinz Kerry | ... | Herself / ... (2 episodes, 2004) |

| Ashlee Simpson | ... | Herself - Singer (segment "Howard Stern") / ... (2 episodes, 2004-2005) |
 | Chris Gregoire | ... | Herself - Governor, Washington (segment "Lethal and Leaking") / ... (2 episodes, 2006-2010) |

| Seth Meyers | ... | Himself - Comedian (segment "Live from New York") / ... (2 episodes, 2004-2013) |
 | Elon Musk | ... | Himself - CEO SpaceX (segment "SpaceX") / ... (2 episodes, 2008-2012) |
 | Joe Namath | ... | Himself (segment "Broadway Joe") / ... (2 episodes, 1968-2006) |

| Dolly Parton | ... | Herself / ... (2 episodes, 1986-2009) |
 | Eli Broad | ... | Himself (segment "The Billionaire") / ... (2 episodes, 2011-2012) |
 | Robert Kraft | ... | Himself - Owner, New England Patriots (segment "The Commissioner") / ... (2 episodes, 2005-2012) |

| Beth Ostrosky | ... | Herself (segment "Dog Nut") / ... (2 episodes, 2005-2007) |

| Malcolm Gladwell | ... | Himself - Author, Outliers (segment "Redshirting") / ... (2 episodes, 2003-2012) |
 | Art Buchwald | ... | Himself / ... (2 episodes, 1968) |
 | Hubert H. Humphrey | ... | Himself / ... (2 episodes, 1968) |

| Richard Nixon | ... | Himself (2 episodes, 1968) |

| Liza Minnelli | ... | Herself (2 episodes, 1975-1986) |

| Thomas Kinkade | ... | Himself (2 episodes, 2001-2004) |
 | Leon Panetta | ... | Himself (segment "Defense Secretary Panetta") / ... (2 episodes, 2012) |

| Meredith Vieira | ... | Herself - Correspondent (1 episode, 1989-1991) |
|

| Diane Sawyer | ... | Herself - Correspondent (unknown episodes, 1984-1989) |
 | James J. Kilpatrick | ... | Himself - Conservative debater (unknown episodes, 1971-1979) |
 | Nicholas von Hoffman | ... | Himself - Liberal commentator (unknown episodes, 1971-1974) |
 | Shana Alexander | ... | Herself - Liberal debater (unknown episodes, 1975-1979) |

| Bob Dole | ... | Himself - Debater (unknown episodes, 2003) |