After Tiger Woods comes clean, America becomes obsessed with the "epidemic" of rich men having sex with lots of women. As a result, Kyle and Butters are labeled as sex addicts and are placed in treatment.
The boys try to write the most graphic, offensive book ever, and then blame Butters when Stan's mom finds it. But when the book is hailed as a work of literary genius, Butters becomes the "voice of a generation."
Randy deliberately gets testicular cancer so that he can receive a medicinal marijuana prescription, while Cartman becomes a black market KFC dealer when all of the restaurants are shut down for being unhealthy.
Tom Cruise gathers other celebrities mocked by South Park and threatens a class action lawsuit unless the town brings Mohammed to them, so that they can obtain his powers not to be ridiculed.
As the celebrities and the gingers battle over who gets possession of Mohammed, the Super Best Friends come to Mohammed's rescue. Meanwhile, Cartman may finally discover the "real" truth about the identity of his father.
The boys stage an intervention for Towelie after he falls off the wagon while working at Timmy and Jimmy's summer camp. At the camp, a jealous camper resorts to dirty tricks to beat Jimmy in a series of competitions.
A new superhero named "Captain Hindsight" emerges to help with a new BP oil spill, and The Coon tries to make sure that he joins his union of superheroes.
Mysterion assumes control of South Park's superhero alliance after The Coon is kicked out. Meanwhile, The Coon plots his plan for revenge by conspiring with the enemy, and where is Captain Hindsight when the world needs him?
Cartman and Cthulhu get their revenge on Coon and Friends, while Mysterion continues to try and discover the secret behind his superpower of never being able to die.