Construction for the new subway tunnel unseals a monster. Four students and the students of Spengler's class 'Paranormal Phenomena 101' forms a new generation of Ghostbusters to battle the demon Akira.
Garrett, Roland and Eduardo repair the equipment while Akira uses Kylie to spread disease. Kylie is freed after they track her down. They upgrade the equipment to stop Akira. Though it seems like Akira is just the beginning.
A clay giant attacks two men vandalizing of a synagogue. Garrett runs into old friends that he used to play basketball and hustle with, Roland is not so welcome. The team deals with racism and bigotry.
A novelist is possessed by a demon, causing him to create several ghostly characters which come to life and terrorize New York. Eduardo is instrumental in solving the case since he is a fan of the writer's work.
After a small-time hood steals a pouch of ancient runes, he learns he can use them to mark people to be possessed and taken to the other side by a demon. The EGBs must not only track down the thief, but also rescue his victims before they are trapped for all eternity.
In the Middle Ages, an alchemist releases a demon which requires a mechanical host. The demon re-appears in present day New York and puts Roland under its spell, causing him to create a deadly mechanical vehicle for its destructive purposes. The EGBs must destroy the ghost in the machine before it destroys all existence.
The bug demon Cohila, who is capable of taking human forms, looks for a female host to be the Queen of his kingdom which will take over New York. Trying to get Egon to notice her and to make him jealous, Janine accepts a date with Cohila and is almost transformed into the bug queen before the EGBs can release her.
When New York suffers an epidemic of pesky ghosts that even the EGBs can't seem to defeat, the Mayor calls on a Pied Piper who claims he can rid the city of its demons. When the Piper's demands grow too outrageous, the Mayor refuses to comply. The piper then reveals himself to be a ghost and lures the city's children into danger, forcing the EGBs to stop him and rescue the kids.
A ghostly salesman arrives in Grand Central Station and twists people's hopes and dreams into terrifying incarnations. When Eduardo falls prey to the Salesman's spell and is turned into Kylie's cat, the EGB's must figure out how to outsmart the ghost before he leaves town forever.
As a gremlin sets out to destroy all communications, transportation and power companies throughout New York City, the EGBs unsuccessfully try to convince the authorities they have a ghost on their hands. Instead of being thanked, the EGBs are arrested and put on an airplane where they have a final confrontation with the gremlin and, at the last minute, manage to capture it.
The Extreme Ghostbusters track down a Banshee whose destructive vocal power endangers the entire city. Their mission hits a snag when Roland comes under the spell of the Banshee's sister, Syren, a paranormal being who uses her identity as a rock singer to hypnotize listeners and drain away their youth.
A temporal disturbance leads Kylie into the New York City of a fallen future, one where humanity's supremacy has been usurped by Paranormal Beings. She joins a band of freedom fighters in a battle against the Paranormal leader, Tempus, a ghost who can simultaneously exist in two separate time planes. Separated by nearly a century, Kylie must find a way to work with the Extreme Ghostbusters, who are battling Tempus in the present. And unless they can find a way to unite in battle, Tempus cannot be defeated.
When a drought threatens the livelihood of an Indian reservation, they reluctantly call upon the Thunderbird, a spirit which brings rain but also much fury. When the Thunderbird flies to New York City, a rash of extreme weather ensues and the EGBs must conquer the fury of this ancient Indian spirit.
A seed containing an ancient Amazon spirit is inadvertently released in New York City and threatens to turn the entire city into a jungle if the EGBs don't stop it first. Is the spirit a benevolent protector of the rainforest, or a malicious demon bent on destroying humanity?
A Leprechaun set loose during the renovation of an Irish pub uses a Shillelagh to suck victims into his "pot of gold." Garret's simultaneous string of bad luck jeopardizes the EGBs ability to catch the Leprechaun. But after secretly kissing the Blarney Stone, Garrett leads the EGBs to rescue Mayor McShane at the height of the St. Patrick's Day Parade.
A ghost living in mirrors decides to inhabit New Yorkers by sucking peoples' souls out and possessing their bodies. Eduardo falls victim to this body-snatching ghost and the EGBs must rescue his "spirit" as they, too, are sucked into the mirror. When only Kylie remains herself, it's up to her to save them and New York.
A mishap while trapping a fiery demon leaves Slimer accidentally trapped inside the Ecto-dimension of the Ghostbuster's Containment Unit. Now incarcerated along with all of the ghosts he helped capture, Slimer is made to pay for his "crimes." Donning a protective suit, Eduardo enters the ghost-plane to rescue Slimer while the other Ghostbusters must extinguish the threat of the Fire Demon who is loose in, of all places, the firehouse.
When a series of nightmares lead to strange physical injuries, the EGBs find themselves battling a surreal spirit bent on dominating the waking world one who channels itself into people's dreams though Barry Sherman, a shock-jock radio host.
The EGBs come up against a deadly ghost serpent that is terrorizing New York. When it proves impossible to stop, they team up with an Ahab-like ghost who has been obsessed his entire afterlife with capturing the ghost serpent. Together they defeat the ghost serpent, thereby allowing "Ahab" to find eternal peace.
The EGBs battle a ghost which feeds on radioactive energy that renders their ghostbusting equipment useless. As the ghost grows more powerful by consuming more energy, the EGBs must devise an alternate way to stop it before the city is destroyed.
After unwittingly releasing a dangerous ghost-bride from an old boarded up wishing well, an ex-yuppie, trying to make some sense of his life, hires the EGBs to protect him from becoming her permanent groom on the other side.
The Mole People, a tribe of humans who live beneath the subways of New York, are being blamed for a rash of power outages. But when a young girl who is one of the Mole People comes to the EGBs for help, they discover that the true culprit is a quartet of ancient lightning demons. A beauty and the beast-like relationship develops between Garrett and the girl, who must ultimately return to her subterranean home.
Fed up with being taken for granted, Janine takes a long overdue vacation and the firehouse falls apart without her. The EGBs hire a temp, Lillith, who appears to be even better than Janine, but is actually an energy-sucking eco-leech queen bent on destroying the EGBs from within.
When the firehouse has to be sprayed for bugs, Egon temporarily moves in with Eduardo and these roommates make an odd-couple match. Meanwhile, the EGBs battle a nasty brood of replicating trolls as Eduardo tries to hide the fact that he's a ghostbuster from his brother.
The old team sticks around to help battle the largest threat the ghostbusters have ever faced, a huge, fog-like, growling amorphous mass of ectoplasm which contains the ecto center of the Bermuda Triangle. As it's heading toward New York and devouring everything in its path, Janine is back at the firehouse preparing a deluxe Thanksgiving feast for ghostbusters, both new and old.
A sphinx preys on the intellectuals of New York, turning them into slobbering idiots when they cannot answer his riddle. The EGBs must stop the ghost before it attacks a meeting of the world's most powerful minds at the United Nations.