For a preview screening on 6 June 2000 in Atlanta, this movie was transmitted in digital form from the studio, across the Internet, to the digital projector at the theater. It never once touched film, and was the first major Hollywood film to be publicly previewed that way.
Because Titan A.E. (2000) didn't do well at the box-office, 20th Century Fox closed its animation studios in Arizona after only two feature films, the first being Anastasia (1997). Fox then contacted Blue Sky studios to produce animated films using 3D computer graphics such as Ice Age (2002) and Robots (2005).
14 years after its release, this is Don Bluth's last animated film, Bluth has remained vague about a return to animated films but his long time collaborator Gary Goldman has been attempting to finance a film based on Bluth's "Dragon's Lair" game.
Although many sentient/sapient species appear throughout the film, only three are identified by name, other than humans: The Drej (the antagonists), Akrenians (Preed's species), and the Gaoul. Production notes and tie-in material also identifies Stith as a Mantrin, and Gune as a Grepoan.