While Dave Chappelle was on Inside the Actors Studio (1994) in 2006, he revealed that he was unhappy with the final product and claimed that the script he co-wrote was much funnier, and that the final result was "a weed movie for kids".
Thurgood mentions to the scientist that his grandfather was in the Tuskeegee Experiments. In real life, Dave Chapelle's grandfather really was in the Tuskeegee experiments, in which thousands of African-Americans were intentionally infected with syphillis.
The trivia item below may give away important plot points.
According to Jim Breuer, the only time he was actually under the influence of marijuana during filming was scene in which Samson is arrested. According to Breuer, Dave Chappelle gave him a bag of marijuana at the end of a day's shooting. Right after smoking it, Breuer was called back to the set because Clarence Williams III wanted to quit the film and demanded that all of his scenes be filmed on that day. Breuer needed multiple takes to get his lines right.