After the car rear-ends the semi trailer and bursts into flames, Meat Loaf's character pulls up to examine the wreckage and there are obviously no bodies in the vehicle, even though there were two men in the car when it crashed.
In chapter 8, when Jack and Earl are involved in a chase with DW and Leroy, you can see that the comfort latches on both Jack and Earl's seatbelts are black. During the chase, they become yellow. Later, after Jack's truck hits the flatbed loaded with crushed cars, they are again black.
In chapter 5 Junior drives the Peterbilt out of the shop it has short smoke stacks, then the truck is started up to back up to the trailer the camera shows black smoke flowing from tall stacks. They then stay long all through the movie.
There was no reason for Crewes to be on I-26, if he were heading from Georgia to New York City. I-26 goes northwest from I85 in South Carolina, and ends at I40 near Ashboro, North Carolina. This would take Crewes several hours out of his way, and would also leave them subject to crossing two additional weigh stations as they backtracked across to I40 to get back to I85 so they could resume a course towards New York City - hardly a wise move for an unlicensed driver who was hauling illegal cargo. If they wanted to avoid detection, they would more likely take a secondary road, such as US221, to bypass the scales altogether.
When Crews is telling the story of his accident on the Atlanta run, he states that he was running up I-75. If he was running Atlanta to New Jersey or New York, as would be assumed if he was trying to make it home for his daughter's birthday, he would not have been on 75 as that would take him through Tennessee, Kentucky, Ohio and eventually through Michigan.
The film takes place on the docks in New Jersey. but at the end of the movie when Earl is on the gurney fixing to be put in the ambulance , the side of the ambulance says "New Hanover County rescue" which is the county where most of the film was filmed.
When Crewes is in the garage and Junior is telling him about the truck, Junior says the truck is equipped with an Eaton-Fuller 10 speed. However, in the scene where Crewe's truck is being blocked in and it shows Crewes shifting, the pattern on the shift knob indicates it is a 9-speed transmission.
The ATF agent said there were reports of 4 trucks slamming each other over 7 miles of interstate. The road they were on was not interstate as evidenced by the double yellow line and no median between the opposing traffic lanes.
In the Weigh Station Scenes, you notice the "North Carolina State Highway Patrol" is the Law Enforcement Agency that mans the Weigh Station. In reality, prior to January 2003, "North Carolina Division of Motor Vehicles Enforcement Section" was the chief agency for North Carolina that enforced "Size and Weight" Laws and staffed the Weigh Stations of North Carolina.
In chapter 17 when Red's hijacker is on the catwalk of the Peterbilt he removes the glad-hand air lines from the trailer. This action would drain all the air out of the trailer causing the trailer brakes to lock up and the wheels to skid.
In chapter 12 when he pulls on the scale at the weigh station his trailer axles make a combined weight of 35,180lbs. The limit is 34,000lbs - add the broken head light assembly and the D.O.T would not have thought twice about stopping him for good. Additionally, any weigh station inspection is going to require the Motor Carrier Enforcement officers to check the driver's license, bills of lading for their cargo, insurance, and permits, which was not done during the scale house scene.