Only Vacation film that does not include a reference to the Walley World amusement park (the original film revolved around visiting the park, Clark had a T-shirt for it in European Vacation, and Clark and Eddie drank egg nog from Marty Moose (mascot of the park) glasses in Christmas Vacation.)
The four vehicles Rusty won throughout the movie that he and his family drove home at the end were: A 1996 Ford Mustang Convertible, 1996 AM General Hummer, 1996 Ford Aspire and a 1996 Dodge Viper RT/10
In the original draft for Vegas Vacation, the Griswolds do not stay at the Mirage Hotel. They stay at the Walley World Hotel and Casino, and Roy Walley was a part of the script. This is a reference to the Griswolds' vacation destination from the first film.
The Keno scene at the end of the film takes place at the MGM Grand Hotel Casino. The family is seen entering through the original "lion's head" entrance, which was present when the casino was first built. This entrance has since been remodeled to look like "regular" doors, with a lion statue on top. The keno section of the casino is no longer there either.
The way the Griswolds travel to and from Vegas are a complete opposite from the first Vacation movie. In Vacation, the Griswolds arrive to their destination by driving and leave by flying. In this film, the Griswolds arrive by flying and leave by driving.
One of the guitarists playing on the cover version of All Along the Watchtower in the film is Marc Ferrari. Ferrari was best known for being a guitarist in the 1980s metal band Keel, who scored hits with tracks like Because the Night and the Right to Rock. Appropriately, that band's singer, Ron Keel, now calls Las Vegas home.
Although it was executive produced by 'Matty Simmmons', it was the only "Vacation" movie series (starring Chevy Chase) not to feature 'National Lampoon's' in its title. It would take another six years for the direct to DVD spin-off film "Christmas Vacation 2" to be released and be credited as "National Lampoon's."
The major plot points are foreshadowed in their first limo drive down the strip. Ellen sees a poster for Wayne Newton, a cab with Club Areola featuring cousin Vicky passes by, and a billboard says, "Four cars won already. You could be a winner too."