The voice talents behind Timon and Pumbaa from The Lion King (1994) appear in the movie. Nathan Lane (Ernie Smuntz) voiced Timon. Maury, the pound owner is played by Ernie Sabella, the voice of Pumbaa.
A rare commercial spot for the film not included in the either the VHS or DVD features a dramatic voice-over introduction "A story about a mouse..." which slowly pans to the shadow outline of the famous Disney character. Then the camera quickly cuts to show that it's actually the little guy from Mousehunt holding a pair of toothpick speared olives which he had been holding close to his head.
The mousetraps scene was done without any digital effect whatsoever. Over 800 mousetraps were set individually and then rigged with wires under the floor. It took several takes, so each trap had to be reset, baited and wired one at a time.
The film features both Nathan Lane and William Hickey. Hickey had previously appeared in The Producers (1968). Lane would subsequently appear in both the Broadway musical based on that film and in The Producers (2005), a film adaptation of said musical.
William Hickey's character, Rudolph Smuntz, leaves his sons a half smoked box of Cuban cigars in his will. In The National Lampoons Christmas Vacation his character, Uncle Lewis, constantly smokes cigars.