| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Brian Haley | ... | The Hooded Avenger | |
| Gary LeRoi Gray | ... | Bobby the Inquisitive Boy (as G. Le'Roi Gray) | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Donavan Freberg | ... | Baby Boolie (as Donovan Freberg) | |
| Beau Weaver | ... | 'Channel Hopping' Announcer (voice) | |
| Billy West | ... | Announcer / Various Characters (voice) | |
| Kevin Weisman | ... | Spike | |
| Patton Oswalt | ... | Seymour (as Patton P. Oswalt) | |
| Downtown Julie Brown | ... | Herself (as Julie Brown) | |
| Barenaked Ladies | ... | Themselves | |
| Bob Scott | ... | Mysteries Announcer (voice) | |
| Harvey the Wonder Hamster | ... | Himself |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Brian Haley | ... | The Hooded Avenger | |
| Paula Jai Parker | ... | Val Brentwood - Gal Spy | |
| Judy Tenuta | ... | Madame Judy the Psychic | |
| Danielle Weeks | ... | Cousin Corky | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Donavan Freberg | ... | Baby Boolie (as Donovan Freberg) | |
| Eddie Deezen | ... | Guy Boarded Up in the Wall (voice) | |
| Beau Weaver | ... | 'Channel Hopping' Announcer (voice) | |
| Billy West | ... | Announcer / Various Characters (voice) | |
| Mike Levey | ... | Himself | |
| Tony Little | ... | Himself | |
| Ron Popeil | ... | Himself | |
| John Tesh | ... | Himself | |
| Grady Lee Richmond | ... | Dream Date | |
| Harvey the Wonder Hamster | ... | Himself |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Brian Haley | ... | The Hooded Avenger | |
| Gary LeRoi Gray | ... | Bobby the Inquisitive Boy (as G. Le'Roi Gray) | |
| Beau Weaver | ... | 'Channel Hopping' Announcer (voice) | |
| Bob Scott | ... | 'Mysteries' Announcer (voice) | |
| David Bowe | ... | Miner | |
| Clarence Clemons | ... | Miner | |
| David L. Lander | ... | Miner (as David Lander) | |
| Michael McKean | ... | Miner | |
| Martha Quinn | ... | Woman in Commercial | |
| Harvey the Wonder Hamster | ... | Himself | |
| Emo Philips | ... | The Slawmeister (voice) (uncredited) | |
| Bob Scott | ... | Voice in educational movie (uncredited) | |
| Brian Michael Tracy | ... | Got Milk Dude (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Brian Haley | ... | The Hooded Avenger | |
| Gary LeRoi Gray | ... | Bobby the Inquisitive Boy (as G. Le'Roi Gray) | |
| Paula Jai Parker | ... | Val Brentwood - Gal Spy | |
| Bob Scott | ... | 'Mysteries' Announcer (voice) | |
| Beau Weaver | ... | 'Channel Hopping' Announcer (voice) | |
| Billy West | ... | Announcer / Various Characters (voice) | |
| Bill Mumy | ... | Delivery Guy | |
| Gedde Watanabe | ... | Kuni | |
| Alex Trebek | ... | Himself | |
| Bill Kirchenbauer | ... | Cold Relief Man | |
| Thomas Dekker | ... | Son | |
| Clement von Franckenstein | ... | Daddy (as Clement von Franchenstein) | |
| Tress MacNeille | ... | Soothing Voice (voice) | |
| Bob Scott | ... | Mysteries Announcer (voice) | |
| Harvey the Wonder Hamster | ... | Himself | |
| Liam Tuohy | ... | Swimmer (uncredited) | |
| Brett Walkow | ... | Camper (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Teri Garr | ... | Herself | |
| Gary LeRoi Gray | ... | Bobby (as G. Le'Roi Gray) | |
| Brian Haley | ... | The Hooded Avenger | |
| Victoria Jackson | ... | Crying Woman | |
| Steve Jay | ... | Himself - Bass Guitarist | |
| Doug Jones | ... | Contortionist #2 | |
| Kerry Norton | ... | Contortionist #1 | |
| Paula Jai Parker | ... | Val Brentwood-Gal Spy | |
| Jon Schwartz | ... | Himself - Drums (as Jon 'Bermuda' Schwartz) | |
| Bob Scott | ... | Mysteries Announcer (voice) | |
| Judy Tenuta | ... | Madame Judy | |
| Rubén Valtierra | ... | Himself - Keyboardist | |
| Beau Weaver | ... | Channel Hopping Announcer (voice) | |
| Danielle Weeks | ... | Cousin Corky | |
| Billy West | ... | Show Announcer (voice) | |
| Jim West | ... | Himself - Guitarist | |
| Joe Ventura | ... | Space Shuttle Countdown Guy (uncredited) | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Todd Patrick Breaugh | ... | Siskel | |
| Brian Haley | ... | The Hooded Avenger | |
| Taylor Hanson | ... | Himself | |
| Zac Hanson | ... | Himself | |
| Jess Harnell | ... | Dr. Legume (voice) | |
| Mark Kineavy | ... | Ebert | |
| Patricia Place | ... | Mrs. Fesenmeyer | |
| Ric Sarabia | ... | Bearded Man | |
| Scott Streltzoff | ... | Free Thrower | |
| Danielle Weeks | ... | Corky | |
| Billy West | ... | Show Announcer | |
| Ian Whitcomb | ... | Sir Alec | |
| Harvey the Wonder Hamster | ... | Himself | |
| Nick Yankovic | ... | Himself | |
| Barry Hansen | ... | Himself (uncredited) | |
| Peyton Reed | ... | Voice of Alien (uncredited) | |
| Jill Talley | ... | Woman in commercial (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Danny Brant | ... | House Band | |
| Charles Fleischer | ... | Buford | |
| Donavan Freberg | ... | Baby Boolie | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Brian Haley | ... | The Hooded Avenger | |
| Wayne Hammerly | ... | House Band | |
| Matthew McCurley | ... | Huey (as Mathew McCurly) | |
| Tahj Mowry | ... | Himself | |
| Brian Otto | ... | House Band | |
| Paula Jai Parker | ... | Val Brentwood-Gal Spy | |
| Jon Schwartz | ... | House Band | |
| Dick Van Patten | ... | Himself | |
| Danielle Weeks | ... | Cousin Corky | |
| Billy West | ... | Show Announcer | |
| Harvey the Wonder Hamster | ... | Himself |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Judy Tenuta | ... | Madame Judy the Psychic | |
| Paula Jai Parker | ... | Val Brentwood - Gal Spy | |
| Danielle Weeks | ... | Cousin Corky | |
| Henry Corden | ... | Fred Flintstone (voice) | |
| Eddie Deezen | ... | The Guy Boarded Up in the Wall (voice) | |
| Gary LeRoi Gray | ... | Bobby (as G. Le'Roi Gray) | |
| Brian Haley | ... | The Hooded Avenger | |
| Marques Houston | ... | Immature | |
| Jerome Jones | ... | Immature | |
| Kelton Kessee | ... | Immature | |
| Cathy Ladman | ... | Cindy | |
| Mary Lynn Rajskub | ... | Weather Woman | |
| John Roarke | ... | Clint Eastwood | |
| Roger Rose | ... | Talk Show Host | |
| Jon Schwartz | ... | Drummer (as Jon 'Bermuda' Schwartz) | |
| Jean Vander Pyl | ... | Wilma Flintstone (voice) | |
| Matt Weinhold | ... | Game Show Host | |
| Billy West | ... | Show Announcer | |
| Mary Yankovic | ... | Herself | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Fabio | ... | Himself | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Daisy Fuentes | ... | Herself | |
| Gary LeRoi Gray | ... | Bobby (as G. Le'Roi Gray) | |
| Doug Jones | ... | Contortionist #2 | |
| Ed Marques | ... | Varna the Squirmese Cook | |
| Kevin McCarthy | ... | Mayor in '60 Percent Chance of Rain' | |
| Kerry Norton | ... | Contortionist #1 | |
| Patricia Place | ... | Mrs. Fesenmeyer | |
| Beau Weaver | ... | Channel Hopping Announcer | |
| Danielle Weeks | ... | Cousin Corky | |
| Billy West | ... | Show Announcer | |
| Mary Yankovic | ... | Herself | |
| Nick Yankovic | ... | Himself | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| John Ennis | ... | Dad in Commercial | |
| Loretta Fox | ... | Mom in Commercial | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Brian Haley | ... | The Hooded Avenger | |
| Dale Hallcom | ... | Three Armed Guy | |
| Barry Hansen | ... | Himself (as Dr. Demento) | |
| Rick Overton | ... | Mr. Molasses | |
| Emo Philips | ... | Dr. Philips | |
| Donna Pieroni | ... | Gym Teacher | |
| Patricia Place | ... | Mrs. Fesenmeyer | |
| Beau Weaver | ... | Channel Hopping Announcer | |
| Billy West | ... | Show Announcer | |
| Mary Yankovic | ... | Herself | |
| Nick Yankovic | ... | Himself | |
| Dweezil Zappa | ... | Himself | |
| Craig Armstrong | ... | Construction Worker (uncredited) | |
| Tress MacNeille | ... | Yoko Ono Voice (uncredited) | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Bryan Blur | ... | Himself (as Radish) | |
| Jimmy Briscoe | ... | Mippy | |
| Drew Carey | ... | Al, after using the instant plastic surgery machine | |
| Eddie Deezen | ... | The Guy Boarded Up in the Wall (voice) | |
| Donavan Freberg | ... | Baby Boolie | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Brian Haley | ... | The Hooded Avenger | |
| Doug Jones | ... | Contortionist #2 | |
| John Kent | ... | Himself (as Radish) | |
| Ben Kweller | ... | Himself (as Radish) | |
| Kerry Norton | ... | Contortionist #1 | |
| Paula Jai Parker | ... | Val Brentwood-Gal Spy | |
| Jack Plotnick | ... | Uncle Ralphie | |
| Judy Tenuta | ... | Madame Judy | |
| Beau Weaver | ... | Channel Hopping Announcer | |
| Billy West | ... | Show Announcer | |
| Fred Willard | ... | Award Show Host | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Judy Tenuta | ... | Madame Judy the Psychic | |
| Paula Jai Parker | ... | Val Brentwood - Gal Spy | |
| Danielle Weeks | ... | Cousin Corky | |
| Todd Patrick Breaugh | ... | Siskel | |
| Dick Clark | ... | Himself | |
| Eddie Deezen | ... | The Guy Boarded Up in the Wall (voice) | |
| Donavan Freberg | ... | Baby Boolie | |
| Stan Freberg | ... | J.B. Toppersmith / Papa Boolie (voice) | |
| Brian Haley | ... | The Hooded Avenger | |
| Mark Kineavy | ... | Ebert | |
| Ed Marques | ... | Varna the Squirmese Cook | |
| Kerry Norton | ... | Contortionist #1 | |
| Patricia Place | ... | Mrs. Fesenmeyer | |
| Jack Plotnick | ... | Uncle Ralphie | |
| The Amazing Johnathan | ... | Uncle Johnathan | |
| Billy West | ... | Show Announcer | |
| Mary Yankovic | ... | Herself | |
| Nick Yankovic | ... | Himself | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |
| 'Weird Al' Yankovic | ... | Himself / Various Characters | |
| Tony Borowiak | ... | Himself (as All-4-One) | |
| Delious | ... | Himself (as All-4-One) | |
| Charles Fleischer | ... | Eggman (voice) | |
| Gilbert Gottfried | ... | Al's Imaginary Friend Gilbert | |
| Gary LeRoi Gray | ... | Bobby (as G. Le'Roi Gray) | |
| Brian Haley | ... | The Hooded Avenger | |
| Jamie Lamar Jones | ... | Himself (as All-4-One) | |
| Alfred Nevarez | ... | Himself (as All-4-One) | |
| Martha Quinn | ... | Woman in Commercial | |
| Randy Savage | ... | Himself (as Randy 'Macho Man' Savage) | |
| Dick Van Patten | ... | The Burglar | |
| Billy West | ... | Show Announcer | |
| Harvey the Wonder Hamster | ... | Himself (uncredited) |