According to creator Van Partible', the main character was named Johnny Bravo because the name originated from The Brady Bunch: Adios, Johnny Bravo (1973), where Greg Brady was nicknamed "the next Johnny Bravo". The name was also derived from Partible's middle name, Giovanni Bravo, which Giovanni is also an Italian name for Johnny.
In the "Biosphere Johnny" cartoon of episode, Johnny Bravo: The Johnny Bravo Affair/Biosphere Johnny/Spa Spaz (2000), Johnny, unused to being trapped in the biosphere, goes into a low-grade form of shock. When asked by a co-captive what he's doing as he stares at the microwave, Johnny answers with something along the lines of "I'm watching my favorite show: Bowl of Macaroni and Cheese going around and around and around... and Eddy!" This is a reference to cartoon series Ed, Edd, 'n' Eddy (1999), which is also a Cartoon Network production.
During the second and third season run of the series, every episode was written from outlines not scripts. The Producers, Writers, and the episode's Director and Storyboard Artist would sit in a room for one day and "Beat-Out" all the jokes while the artist "Roughed-Out" drawings on Post-Its. This was intended to shorten the time back and forth between Writer/Producer/Director/ and Artist and cut down on miscommunication.