Lida 'Stony' Newsom, Cleopatra 'Cleo' Sims, Francesca 'Frankie' Sutton and Tisean 'T.T.' Williams are four female inner city Southern Californian childhood friends. Now adults, "Set It Off" focuses on life's series of unfortunate events and taking vengeance on life with an Uzi in hand. They embark on a series of robberies in the Southern California banking district to fund their escape from a life surrounded by tragedy, poverty and despair. That triggers an over diligent Detective Strode and his female partner, Detective Waller, on a hunt for the "armed and dangerous" women. That triggers another series of unfortunate that corners Lida 'Stony' Newsom into choosing between her new found love interest and friends.