Milos Forman claims Courtney Love showed up to their first meeting while under the influence of drugs. Just when he was going to dismiss her, he realized that Love was perfect for the role of Althea. Forman offered her the role on one condition: that Love would stay clean and undergo regular drug testing during filming. She complied. To this day, Love credits Forman with getting her off drugs which led to a career renaissance.
One scene involves Hustler's offer of a $1 million reward for bringing JFK's killers to justice. The father of actors Woody Harrelson and Brett Harrelson has long been suspected by conspiracy theorists of involvement in the assassination.
Courtney Love was arrested several times in Mississippi and Tennessee during filming for wearing her outrageous and revealing costumes in public. While filming a particular scene in a jail, one of the female officers working mistook Love for being a criminal on her way in for booking and handcuffed her.
Lawyer Alan Isaacman, played by Edward Norton, is a composite of a few lawyers that represented Flynt over the years and is not the lawyer who was shot along with Flynt. That lawyer is Gene Reeves Jr. who (as of April 2012) is a senior magistrate Judge in Gwinnett County at the same courthouse at 75 Langley Drive, Lawrenceville, GA outside of which he and Flynt were shot.
Larry Flynt's comment at the rally that "if you believe anything you can do with your body is wrong, it's the fault of the manufacturer" was originally a famous gag line used by the late comedian Lenny Bruce, who also went through a number of court cases charging him with obscenity.
In the scene before Judge Mantke in which Larry Flynt refuses to swear an oath on the Bible to tell the truth in court because he's an atheist, he is allowed to "affirm" that he will tell the truth. This is an exception to the oath requirement originally written into the law to accommodate Quakers, who by the tenets of their religion are not allowed to "swear" to anything.
According to Rev. Jerry Falwell and contrary to what we see in the film, he did not find out about the parody ad in "Hustler" from his staff at Liberty University. He was alerted to the ad when someone in the media asked him about it.