Shawn Wayans's character early in the film states that his father is only a few years older than him. This is making fun of the fact that Cuba Gooding Jr. is only 7 years younger than Laurence Fishburne who played father and son in Boyz n the Hood (1991).
Loc Dog warns Ashtray about how promiscuous Dashiki is, and does so by saying, "She got more kids than Ms. Wayans." That is a joke in which Marlon Wayans (Loc Dog) is actually referring to his real-life mother who has ten children, which include him and Shawn Wayans (Ashtray) as well as Keenen Ivory Wayans the mailman.
The trivia item below may give away important plot points.
Actor Samuel Monroe Jr. played the same part in both 'Don't be a Menace to South Central While Drinkin Juice in the Hood' and Menace II Society (1993), he was the one trying to defend his cousin's honor because she was pregnant, but ended up getting his face stomped into the pavement in both movies in just about the same exact way.