Jeff Daniels (Roger) says that on more than one occasion, he heard an authoritative voice on the dog-strewn set shout "Sit!" and immediately plopped himself into a chair only to be told, "Not you, Jeff."
Glenn Close initially rejected the role of Cruella due to scheduling conflicts with the stage musical "Sunset Blvd." The producers then offered the role to Sigourney Weaver who also declined. By that time, Close had ended her run on Broadway, and when the producers offered her the role again, she accepted.
The Disney computer game "101 Dalmations Animated Storybook", which takes the user through the story in interactive ways, has a mixture of story elements from both the animated and live "101 Dalmations" movies: in the game, most details follow the animated version of the film. However, Roger and Anita have the same jobs as in the live film: Roger's a video game designer and Anita works for Cruella as a clothes designer, which gave Cruella the nasty idea for a genuine Dalmation coat (in the original animated film, Roger was a songwriter and Anita's job was never mentioned; she did not work for Cruella and knew her only as an old school mate). Also in the game, Roger and Anita meet in the park while taking their dogs for a walk; they end up colliding simultaneously in the pond, as they do in the animated film. However, they do so while on their bicycles, which was a detail exclusively from the live film. The game also shows only one dog rescue the puppies from the De Vil manor; this is a detail similar to the live movie, while in the animated movie, a cat and dog both banded together to save the puppies.
This movie was never aired on any pay-TV network, up until 2016 when this film was a part of HBO and Cinemax's catalog of archival titles from Walt Disney Studios Motion Pictures. HBO and Cinemax were the first and only pay-TV networks to air this film.