 | Frank Welker | ... | Dr. Jeremiah Surd / ... (21 episodes, 1996-1997) |

| Quinton Flynn | ... | Jonathan 'Jonny' Quest / ... (12 episodes, 1996-1997) |

| J.D. Roth | ... | Jonathan 'Jonny' Quest / ... (10 episodes, 1996-1997) |

| Robert Patrick | ... | Roger T. 'Race' Bannon / ... (10 episodes, 1996-1997) |

| Michael Benyaer | ... | Hadji Quest-Singh / ... (10 episodes, 1996) |

| George Segal | ... | Dr. Benton C. Quest (9 episodes, 1996-1997) |
 | Jennifer Hale | ... | Jessica Margret Leya 'Jessie' Bannon / ... (9 episodes, 1996-1997) |
 | Rob Paulsen | ... | Hadji Quest-Singh / ... (9 episodes, 1996-1997) |
 | Jesse Douglas | ... | Jessica Margret Leya 'Jessie' Bannon / ... (9 episodes, 1996) |

| Chick Vennera | ... | Lorenzo / ... (8 episodes, 1996) |

| Granville Van Dusen | ... | Roger T. 'Race' Bannon (8 episodes, 1996) |
 | John de Lancie | ... | Dr. Benton C. Quest / ... (7 episodes, 1996-1997) |
 | Robert Foxworth | ... | Roger T. 'Race' Bannon (7 episodes, 1996-1997) |
 | B.J. Ward | ... | Iris the Computer / ... (6 episodes, 1996-1997) |
 | Don Messick | ... | Dr. Benton C. Quest (6 episodes, 1996-1997) |
 | Michael Bell | ... | Ezekiel Rage / ... (5 episodes, 1996-1997) |
 | Megan Cavanagh | ... | Julia / ... (5 episodes, 1996) |
 | Nancy Linari | ... | Julia / ... (5 episodes, 1996-1997) |

| Jim Meskimen | ... | Black Jack Lee Imposter / ... (5 episodes, 1996-1997) |

| Clyde Kusatsu | ... | Dr. Zin / ... (4 episodes, 1996-1997) |
 | Ed Gilbert | ... | Badur / ... (4 episodes, 1996) |
 | Michael Stanton | ... | Additional Voices / ... (4 episodes, 1996) |
 | Darleen Carr | ... | Abby / ... (3 episodes, 1996-1997) |

| Paul Eiding | ... | Bennett / ... (3 episodes, 1996) |
 | Michael Horse | ... | Ames / ... (3 episodes, 1996) |

| Helene Udy | ... | Belle / ... (3 episodes, 1996) |

| Mark Hamill | ... | Eldoradoan / ... (3 episodes, 1996-1997) |
 | Jim Cummings | ... | Captain Simms / ... (3 episodes, 1996) |

| Nick Jameson | ... | Cop / ... (2 episodes, 1996) |

| Maurice LaMarche | ... | Arun / ... (2 episodes, 1996-1997) |

| Mayim Bialik | ... | French Woman / ... (2 episodes, 1996) |
 | June Angela | ... | Anaya / ... (2 episodes, 1997) |

| Lucy Liu | ... | Melana (2 episodes, 1997) |
 | James Shigeta | ... | Inspector Mantjur / ... (2 episodes, 1997) |
 | Irene Bedard | ... | Alice Starseer / ... (2 episodes, 1996) |

| Tim Lounibos | ... | Airport Security Guard #1 / ... (2 episodes, 1997) |
 | Don Reed | ... | Jamie / ... (2 episodes, 1996-1997) |
 | Edward Winter | ... | Guard / ... (2 episodes, 1996-1997) |
 | Dorian Harewood | ... | Guard / ... (2 episodes, 1996-1997) |
 | Clive Revill | ... | Harpooner / ... (2 episodes, 1996) |

| Clancy Brown | ... | Col. Nikolai / ... (2 episodes, 1997) |
 | Tasia Valenza | ... | Jade (2 episodes, 1997) |
 | Earl Boen | ... | Dr. Forbes / ... (2 episodes, 1996-1997) |

| Kevin Michael Richardson | ... | Computer / ... (2 episodes, 1996-1997) |

| Nick Tate | ... | Darcy / ... (2 episodes, 1996) |

| Brock Peters | ... | Masai / ... (2 episodes, 1996-1997) |

| Brian Tochi | ... | Professor Ken Otsuki / ... (2 episodes, 1996-1997) |
 | Michael Des Barres | ... | Merlin / ... (2 episodes, 1996) |
 | S. Marc Jordan | ... | Curator / ... (2 episodes, 1996) |
 | Robert Ito | ... | Controller / ... (2 episodes, 1996) |

| Marc Singer | ... | Mitchell Stramm / ... (2 episodes, 1996) |
 | Theresa Saldana | ... | Estella Velasquez (2 episodes, 1996-1997) |

| Tara Strong | ... | Irina Kafka / ... (2 episodes, 1996-1997) |
 | Jeff Bennett | ... | Crew #2 / ... (2 episodes, 1996) |
 | Karen Ross | ... | Dr. Simone Duval / ... (2 episodes, 1996) |
 | Carolyn Seymour | ... | Aleutian Woman / ... (2 episodes, 1996) |
|
 | Mark Taylor | ... | Additional Voices (unknown episodes) |
|
| Christopher Bracher | .... | computer animation system designer (52 episodes, 1996-1997) |
| Stephen Toback | .... | computer animation system designer (52 episodes, 1996-1997) |
| George Cox III | .... | color stylist (3 episodes, 1996-1997) |
| Martin Crossley | .... | xerographer (3 episodes, 1996-1997) |
| Alison Leopold | .... | ink and paint supervisor (3 episodes, 1996-1997) |
| Star Wirth | .... | xerographer (3 episodes, 1996-1997) |
| Kunio Shimamura | .... | associate animation director / overseas animation supervisor (2 episodes, 1996-1997) |
| Doug Williams | .... | overseas animation supervisor (2 episodes, 1996) |
| Aaron Crippen | .... | animation checker / timing supervisor (2 episodes, 1997) |
| Andrew Gentle | .... | lead background designer (2 episodes, 1997) |
|
| Sandy Benenati | .... | animation checker (unknown episodes) |
| |
|
| Collette Sunderman | .... | talent coordinator (22 episodes, 1996) |
| Matthew Malach | .... | adr director (21 episodes, 1996) |
| Cindi Peltier | .... | talent coordinator (21 episodes, 1996) |
| Kris Zimmerman | .... | adr director (21 episodes, 1996) |
| Diana Ritchey | .... | production coordinator / production assistant (14 episodes, 1996-1997) |
| Peter Lawrence | .... | story editor (2 episodes, 1996) |
| Michael Ryan | .... | additional story material / assistant story editor (2 episodes, 1996) |
| Carlos Lemos | .... | background design (2 episodes, 1997) |
| Glenn Leopold | .... | story editor / production coordinator (2 episodes, 1997) |
| Jesse Santos | .... | background design (2 episodes, 1997) |
|
| Liza Breuninger | .... | lead production accountant (unknown episodes) |
| |