Nash Bridges and Joe Dominguez enlist the help of a prison inmate whose former partner is willing to kill anyone to find missing money from a job they pulled years back. Lisa's new business partner isn't what he seems.
A former mobster in the witness protection program comes out of hiding and embarks on a killing spree of his former partners in crime. Joe looks forward to Inger and the new baby leaving town for a few days.
While trying apprehend a suspect who is impersonating characters from Sherlock Holmes novels Nash and Joe encounter a mentally ill man who is also the trail of the suspect, and he believes that he himself is Dr. Watson.
Nash's brother has come back from M.I.A. and may be involved in the string of murders happening. With Joe on vacation, Nash must rely on the rest of the team for help. While Lisa is away, her sister stays to watch Cassidy, causing some disagreements with Nash.
A criminal is released from jail by mistake and wants revenge on Michelle. Nash teams with Michelle to capture him. Meanwhile, Nash refuses to partner with Joe on an off duty case to protect a sportscaster being blackmailed.
A prisoner facing a parole hearing sets up a bounty website to have Nash killed in order to avoid Nash keeping him locked away after the hearing. Nash worries that Cassidy's new boyfriend who she's serious about, may be playing for the other team.
Joe Dominguez and the rest of the SIU cover for Nash after he has his drink spiked with LSD. Geraldo Rivera wants to interview Joe and Nash for his television show, but is given the run around until Nash can recover.
Bettina, upon learning that Nash has nearly a year's worth of vacation time, tells him to take it. In the meantime he brings in a new guy to fill in, and he starts by investigating a murder with Joe. Nash tries to find a way to get back.
Nash and Joe help and out-of-state female cop nab a celebrity stalker, but not before frictions between her and Joe reach a boiling point. Evan, after a one night stand with a woman he doesn't know, learns that she has stolen his badge.
Nash and his SIU team search for the source of deadly VX nerve gas before there are catastrophic consequences. Meanwhile, things heat up between Cassidy and Evan, and a young woman believes that Joe might be her father.
Nash investigates several ex Navy Seals who they suspect are behind a series of armored car robberies. A pro football player hires Nash and Joe to find a beautiful woman he saw in the crowd-who happens to be Nash's ex-girlfriend.