Visions of a plane crash bring Frank Black back into service for the FBI. While investigating the crash site Frank meets Agent Emma Hollis, together they piece together a plot to exterminate sisters who are remote viewers.
Frank and Agent Hollis investigate the deaths of several sisters and their daughters who appear to be genetically engineered "remote viewers". They must find the remaining sisters quickly in order to save them from government assassins.
A woman is on the run after she escapes from a Psychiatric facility being accused of murder. The case takes an interesting path after the FBI is sent to track the woman. Frank is sent there to investigate the case and Agent Emma Hollis associates the case with a conspiracy theory.