Visions of a plane crash bring Frank Black back into service for the FBI. While investigating the crash site Frank meets Agent Emma Hollis, together they piece together a plot to exterminate sisters who are remote viewers.
Frank and Agent Hollis investigate the deaths of several sisters and their daughters who appear to be genetically engineered "remote viewers". They must find the remaining sisters quickly in order to save them from government assassins.
On Christmas, Frank (Lance Henriksen) and Jordan (Brittany Tiplady) go one vacation in Vermont. Unexpectedly, they get involved with a supposedly dead Mafia hitman who appears to be living in the woods with a number of mysterious women.
Someone mails Frank (Lance Henriksen) a cassette tape containing seemingly harmless white noise. But Frank links copies of the tape to the bizarre deaths of two people. Also Frank is visited by the ghost of his dead wife.
A woman is on the run after she escapes from a psychiatric facility being accused of murder. The case takes an interesting path after the FBI is sent to track the woman. Frank is sent there to investigate the case and Agent Emma Hollis believes there's a conspiracy behind this case.
When Frank (Lance Henriksen) receives a series of Polaroid photographs, showing his own death. Frank claims that someone is out to kill him, but authorities suspect he may be having a nervous breakdown.