There is a DJ known as Nocturnal Ned who works at Arnold's hometown radio station MJZZ. Nocturnal Ned is actually a caricature of "Hey, Arnold!" creator Craig Bartlett, who also provides his voice in various episodes.
The sign outside the Sunset Arms Boarding House reads "No Children, Pets OK". This sign can be seen in various places in other episodes, most noticeably at the pool Arnold and Gerald unsuccessfully get into in the heat wave episode.
In the Halloween episode where Arnold and his friends fake an alien invasion, the name of the place where the "U.F.O." (actually the water tower with Christmas lights) landed is Well's Ridge. This is a reference to Orson Welles, who did a fake radio broadcast in which aliens landed on Earth.
Helga's middle name, Geraldine, is a tribute to former Nickelodeon executive Geraldine Laybourne. This was confirmed by the show's creator Craig Bartlett in a chat in which he revealed that Geraldine was what the G. in Helga G. Pataki stood for.
Ruth P. McDougal was originally Arnold's love interest, and as Arnold talks about her, Gerald constantly tells him that it's hopeless because she's a sixth-grader. However, as Lila was introduced, Ruth was phased out.
In the episode "Curly Snaps", Curly locks himself in Principal Wart's office with a bag of kickballs and says " I'm mad as heck, and I'm not going to take it anymore!". This is a rendition of the famous line "I'm mad as hell, and I'm not going to take it anymore!" from the 1976 film "Network".
In episode "World Records", one of the records in Arnold's book is set by a fictional person named Frannie Caudell. The voice of Helga is Francesca Marie Smith, and the voice of Arnold at the time was Lane Toran.
After Nickelodean green lit the pilot, it aired first as a special before Nickelodeon's first movie, Harriet The Spy. It was titled "Arnold" & would end up being re animated with a nearly identical premise