Peter is beginning to give up. He's tired of Spider-Man being called a menace when he tries to help. But when he receives a letter from Spidey's #1 fan, Tina, he decides to give Spider-Man one last swing.
Tombstone, one of Silvermane's former henchmen, has returned and is threatening to ruin the life of childhood pal, Robbie, if he doesn't destroy the story that he's about to print about the Silvermane family.
After Tony Stark eliminates Dr. Ohn's research on dimensions, Ohn makes a deal with the Kingpin. After a malfunction in his new lab, Ohn is sucked into another dimension and becomes a powerful being, know as The Spot.
Baron Mordo is back. He is planning to steal Tony Stark's technology on dimensions so that he can bring the being known as Dormammu to Earth. But he will also need the help of Spider-Man's greatest enemy: Venom.
The Venom symbiote has produced a new symbiote, attaching itself to serial killer Cletus Kasady to give birth to Carnage. As Venom's replacement, Carnage helps Mordo with his plans. Now, Spider-Man must team up with Venom and Iron-Man.