The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.
The Sliders arrive in what is literally the happiest place on Earth. But in this small community, a little girl witnessed her grandfather leap into a mysterious chasm and begins to feel an overwhelming sorrow. Worse yet, it soon spreads to Rembrandt and Maggie.
A rough slide separates Quinn and Maggie from Rembrandt and Colin for a brief time. Soon after they reunite, Quinn and Maggie become seriously ill and appear to be dying of old age. Unable to help them themselves, Rembrandt and Colin will have to rely on someone claiming to be Quinn and Maggie's son.
With nearly a month until their next slide, the Sliders find themselves extremely bored on a dull world. While the others get jobs, Rembrandt dives into a sci-fi book that bears more than a resemblance to their lives. When the Sliders track down the author, they learn he came from Quinn and Colin's home world.
The Mallory brothers become separated from the rest of the sliders when another person appears in the vortex with them. Quinn appears to have jumped into the body of himself in the world they arrived in, but the fate of his brother remains unknown.
The Sliders land on an Earth with a similar technology level to the one they just left. Dr Davis sets about trying to figure a way to separate the two Mallorys. She also has the unsettling experience of meeting herself in this new world. Beckett continues to struggle with the emotions of possibly losing her 'Mallory'.
The Sliders land on a non Earth world. They appear to be caught in another dimension. The situation becomes more desperate when their timer fails and they appear to be in the middle of Kromagg - Human war.
The Sliders land on an island inhabited by Monks - With Maggi suffering from an fever or infection the team seeks help from the islanders. There seems to be more going on than the Monks are admitting too, and the sliders run the risk of missing their jump.
The Sliders arrive in a new world just as that world's Mallory is shot dead by Rembrandt and witnessed by Davis. The local police seem uninterested in the case, the reason for which become apparent very quickly.
The Sliders arrive in a world in which Maggie is an internationally famous astronaut who died on a mission to Mars. Maggie initially enjoys the world until she is recognized and becomes the prize in an unusual tug of war.
Through a series of slide, Rembrandt begins to have hallucinations about a former team mate, Wade. When all the team begin to see random vortex opening around them Rembrandt becomes convinced Wade is still alive and the vortex can lead him too her.
The Sliders land in a mental institution that is in the middle of riot in a world where creativity is banned. In the confusion they become separated and need to find each other before the vortex opens up again.
The Sliders find themselves in a world seemingly devoted to gaming. They decide to take the opportunity to indulge themselves and have a holiday. They quickly discover the games are far more complex and dangerous than any of them realized.
The team discover their timer for slides has begun to malfunction and is in need of repair. They have 48 hours to figure out how it works and effect repairs or risk being stranded in their current world.