In a dark world of mysticism and witchcraft imagery, Quinn finds he has a bounty on his head or to be specific, his brain which a witchdoctor selects as payment after running out on a medical bill. The Sliders seek the "Sorcerer" who promises to return them home if they help him.
In a world where technology has been banned after the event at Hiroshima, the Sliders must find a way to fix the timer that was damaged by lightning. Quinn doesn't fully materialize and must accompany his friends in a ghost-like state in the astral plane as they run into the Bureau of Anti Technology whose real motive is to build up their technological cache.
In a world where San Francisco is part of the Republic of Texas and a combination of Western culture and technology exists along with saloons and office buildings, the Sliders find themselves in the middle of a hostile takeover attempt by corporate gunslingers who give the term "negotiate" a new meaning. Rembrandt finds himself at the exchange table where poker is played for corporate stock.
In a world where San Francisco serves as a prison, two new sliders join the regulars. One is a woman, Michelle, whom Quinn saved from a beating. The other is her savage boyfriend, Sid, who followed them. The Sliders are fitted with buddy bracelets which are used in a buddy system of justice. If one "buddy" commits a crime then the other is punished. Of course Quinn is responsible for Sid's predictable actions. The timer becomes a hot commodity for both prisoners and guards who want to escape an earthquake doomed city.
The Sliders land in a world where J. Edgar Hoover founded the nation and martial law has been in effect for 30 years. Chased by government officials, they must make a choice of whether to protect the last surviving copy of the Constitution which could sprout the idea of democracy or gain the release of a former judge who has some potential to be a new founding father.
In a world where San Francisco is a national park for the endangered dinosaurs, Professor Arturo stumbles and loses the timer. The Sliders are at the mercy of a poacher's whim if they want to survive but find assistance in a holographic park ranger.
In a world that greatly resembles the Sliders' place of origin, everyone must decide whether to stay or leave the doubles of their loved ones in order to find their way home. Professor Arturo's double steals the timer and claims the invention of Sliding as his own. A physical struggle ensues among the two professors.
In a world where Bugsy Siegel succeeded in establishing a gambling empire in Northern California controlled by organized crime, Rembrandt and the others inadvertently disrupt the marriage of two families. Mistaken for the FBI Deputy Director and the Incorruptibles, Rembrandt leads a severely underfunded crime unit in a sting in order to save himself and his friends.
In a world with Howard Stern as president, adults over the age of thirty are treated as second class citizens who must then retire. Quinn fills in for his recently murdered double in an attempt to promote the EduLearn computer technology designed to replace human educators. However, he has seconds thoughts when he learns of this culture's desperate race to succeed before the mandatory retirement age. Arturo and Rembrandt handle curfew violations in a court of what is surely not their peers.
After accidentally shooting down a spacecraft, the Sliders are pursued between worlds by the eye-eating Kromaggs, in their first appearance, as this new enemy hunts and then interrogates them for their home coordinates while in prison on Earth 113.
In a world where San Francisco is part of the Republic of Nueva Espana, the Sliders are arrested by immigration police and sentenced to deportation to Canada. Quinn meets up with an old high school flame, Daelin, who helps in the escape despite a great loss to her. In the next world, Quinn sets her up with his double in Seattle after an abusive relationship. In the third world, they slide into a jail cell where they await trial for the murder of Daelin, an undercover policewoman. In this realm, clocks and blocks of time move backwards for them alone. Quinn learns that...
The sliders arrive on a world that has dwindling natural resources. While there, Rembrandt gets sidetracked by his number one fan. Meanwhile, Quinn and the others meet a group of scientists trying to perfect a sliding device of their own. While they may have the technology to get the sliders home, all is not what it seems.
The Sliders end up in a desert wasteland battered by an endless series of tornadoes. They find one agrarian village run by a dictatorial elder. Wade finds herself imprisoned while the rest are banished without the timer.
On a world where time moves at a slower rate, Quinn encounters his young double and tries to change a traumatic event in his life. Meanwhile, Arturo decides that it's time to grab life by the horns and takes the others on increasingly wild excursions.
The sliders encounter trouble on a world where social outcasts have harnessed the power of dreams. When Wade becomes the focus of this group, the sliders must rally together to protect her from her worst fears.
The Sliders interrupt the abduction of a young woman, Melinda. Quinn is recognized by one of the attackers as a Mallory, prompting the attacker to turn into a bird and fly away. The Sliders pass the woman to the authorities and discover she is apprentice of a disgraced Druid, Gareth, who's been thrown out the movement for practicing black magic. Quinn is enamored by the girl and launches a rescue attempt. Gareth senses Mallory's desire for Melinda and uses her as bait. Having succeeded in capturing Mallory, Gareth transfers his own essence into Quinn's body. Meanwhile...
During a jump the sliders encounter a world consumed by fire. As they wait for the next jump, a matter of seconds, Quinn sees some diffused object coming towards them. They jump through the portal as the 'thing' follows them. They arrive in an oil town that has disturbing under currents of union and company actions. The flame creature reveals itself and begins burning everything, multiplying as it goes. As Quinn considers events at the world, he wonders what was really going on. The Sliders go to work at the oil refinery to get money and quickly become embroiled in ...
The Sliders arrive in a USA that is a constitutional monarchy. Arturo is injured during the slide, and Rembrandt is mistaken as the Prince of the USA. Complications set in when Lady Danielle has issues during her pregnancy, and the baby needs to be transferred in Rembrandt's body. Some years earlier a virus swept the world forcing all pregnancies to term during the second trimester. Rembrandt can carry the baby to term, but will miss the slide to do so. Meanwhile intrigue develops as Lady Mary appears to be behind a series of assassinations of the King and his ...
The Sliders arrive in a world virtually crime free. What criminals there are perform on a game show where they play for their lives. Mallory is captured due to previous convictions by his double on the world. The rest of the Sliders go to the studio where the show is made. The correct Mallory sees the show and is dumbfounded by the turn of events. As the trial continues, Wade and Rembrandt decide to uncover any information about the real crime they can. Despite Arturo's best efforts Mallory is found guilty and sentenced to death live on TV.