In a world where tattooed humans are hunted for sport by the new Kromaggs/Human half-breeds, the Sliders attempt to save a captive Colin. Rembrandt is poisoned and needs the help of his enemy to survive.
The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.
The Sliders arrive in what is literally the happiest place on Earth. But in this small community, a little girl witnessed her grandfather leap into a mysterious chasm and begins to feel an overwhelming sorrow. Worse yet, it soon spreads to Rembrandt and Maggie.
A rough slide separates Quinn and Maggie from Rembrandt and Colin for a brief time. Soon after they reunite, Quinn and Maggie become seriously ill and appear to be dying of old age. Unable to help them themselves, Rembrandt and Colin will have to rely on someone claiming to be Quinn and Maggie's son.
With nearly a month until their next slide, the Sliders find themselves extremely bored on a dull world. While the others get jobs, Rembrandt dives into a sci-fi book that bears more than a passing resemblance to their lives. When the Sliders track down the author, they learn he came from Quinn and Colin's home world.