Began as a series of short films for MTV. Each of these films, plus a couple of full episodes, ended with Aeon Flux being killed, with continuity being "rebooted" in the following episode. (The 2005 Æon Flux (2005) live action movie explained that Aeon is cloned each time she is killed.) This angle was phased out over time. Plans for a fourth season were discussed but never fulfilled.
It has been considered that the cartoon may have been a possible influence behind South Park (1997). In that cartoon, the character Kenny McCormick is killed off in each episode, but at the beginning of the following episode, Kenny is alive, only to die again.