Baker's inability to throw the ball back to the pitcher was based on former New York Mets catcher Mackey Sasser. Sasser was very successful at throwing out runners attempting to steal second, but had a mental block causing him to flinch several times when trying to throw the ball back to the pitcher. Many baserunners took advantage of this affliction and stole bases while he was triple pumping his throw, and/or lollipopping the throw back.
The character Isuro Tanaka was something of an anomaly of that time. At the time of the film's release, there were no Japanese players in the Major Leagues, and only one Japanese player had ever played (briefly) for a ML team. The influx of Japanese players in US Major League baseball didn't begin until a few years after the film's release.
During filming, the real Cleveland Indians were moving out of Cleveland Municipal Stadium into Jacobs Field (now known as Progressive Field) on the other side of Cleveland. However, Jacobs Field was not yet finished being constructed, so the movie was shot at Oriole Park at Camden Yards in Baltimore, home of the Baltimore Orioles (which Cleveland's Jacobs Field was modeled after). The first "Major League" movie also used a different ballpark outside of Cleveland, Milwaukee County Stadium, as the Indians' home.
Although the White Sox are portrayed as the heavies of the film, their history has been almost as tormented as that of the Indians. Said to be the defending World Series Champions in the film, at the time of its production and release the White Sox had not won an AL Pennant since 1959 or a World Series since 1917. Then, the White Sox won an AL Pennant and the World Series in 2005.
The spring training scenes were filmed in Harrisburg, Pennsylvania. They used the baseball stadium of the Harrisburg Senators located on City Island. Potted palm trees were placed outside the stadium to help in the illusion of a more southern location.
In 2009, the Cleveland Indians played a game against the Kansas City Royals at Progressive Field where Shin-Soo Choo hit a ball into center field which hit a seagull. This was similar to a scene in Major League II where Pedro Cerrano hit a Pigeon in center field. However, Choo did not reprise Cerrano's performance of running from first base to center field to save the bird.
The film portrays the Indians winning the AL East, and the White Sox winning the AL West under baseball's two-division format. The year the film was released was baseball's first season with the three division and Wild Card format in which the Indians and White Sox played in the newly formed AL Central division.
As Shoup is lifted for Vaughn, he comments that he can't believe he couldn't get that "Punch and Judy" hitter. A Punch and Judy hitter with very little power, one that very rarely hits the ball past the infield, and usually has a very low slugging average.
Extra Baseball players John Stefero, Brad Tyler, and Jeff Sheaffer all played in the Baltimore minor league system, all playing at one time for the AAA Rochester (NY) Red Wings. Schoop (Kevin Hickey) as well played for Rochester, and was a teammate with Brad Tyler.
One night, while filming in Harrisburg, Pennsylvania, 'Charlie Sheen' and other stars of the movie boarded a bus and visited Central Pennsylvania Business School (now Central Pennsylvania College) for a party.
When Charlie Sheen (Rick 'Wild Thing' Vaughn) is on the Jay Leno show he discusses a car he stole and was chased by the cops through 4 states. Sheen just recently got done filming The Chase which was filmed before majors league 2. The Chase is a 1994 film in which Charlie sheen steals a car and takes a hostage and is chased by the cops throughout the film through multiple states.
In the film, Rube Baker (Eric Bruskotter) brings up the possibility of being sent to Omaha. However, Omaha has been the home city of the Kansas City Royals's AAA affiliate since the Royals began Major League play in 1969. At the time when this film was set, the Cleveland Indians's AAA affiliate was the Colorado Springs Sky Sox. As of 2017, the Indians's AAA affiliate is the Columbus Clippers.