Aamir Khan was originally given the role of Prem, but he refused to act in the movie, because he didn't find the script appealing. Salman Khan who was going through a bad career phase was then signed. The movies massive success, revived Salman Khan's career, which was originally doomed with successive flops.
Lata Mangeshkar, who sang more than 10 songs in the movie, had long retired from accepting awards, but the public demand for the song "Didi Tera Devar Deewana" was such that she received the Filmfare Special Award that year.
Filmmaker Karan Johar named it as the one film that changed his life. He said, "After seeing Hum Aapke Hain Koun..! I realized Indian cinema is about values, tradition, subtlety, romance. There is so much soul in it."
The film was originally released in only a small number of theaters that agreed to upgrade their facilities. Due to widespread demand for the film after release, many other theaters upgraded in order to get the film. As a result ticket prices were raised, and more people came back to theaters who had been lost to television.
The song "Dhiktana (Part 1}" was sampled in the song "We Got More" by Luniz feat. Shock G. The flute part. The song was featured in the Hollywood movie Don't Be A Menace in South Central in South Central While Drinking Your Orange Juice.