- The Creature is brought to life in a metallic vat, as in Thomas Edison's Frankenstein (1910).
- Victor cuts an executed criminal from a hangman's noose and uses the body for his experiments, as in James Whale's Frankenstein (1931).
- Another homage to Whale's Frankenstein: The Creature is reanimated with electrical charges. This is an invention of Hollywood; the book is silent on how Victor creates the Creature.
- Another homage to Whale's Frankenstein: Once the Creature comes to life, Victor triumphantly shouts, "It's alive!".
- The Creature's first spoken word is "friend." This is also the Creature's most frequently-used word when he learns to speak in Whale's The Bride of Frankenstein (1935).
- Victor uses the brain of a brilliant scientist/mentor for his Creature, as in Hammer's The Curse of Frankenstein (1957). Justine Moritz's role is also expanded and is made to fall in love with Victor in both films.
- Victor's mentor, who paves the road for his experiments, brings a severed arm back to life and shows it to Victor, as in Frankenstein: The True Story (1973).
- The Creature hides in some cottagers' pigsty and secretly learns to speak and read from observing them through a peephole. In the book, the cottagers are foreign refugees. In this film, the cottagers are simply local townsfolk. This variation on the novel was first used in Calvin Floyd's Terror of Frankenstein (1977).