A widowed father with two children has to deal with one daughter having sickle cell anemia. When the daughter gets seriously sick and the local doctor is not available, his daughter dies while he tries to find help.
Max and Elmer are long-time friends. Max is slowly dying due to smoking cigarettes for many years. Elmer tries to get him to stop, but he will not listen. After Monica, Tess, and Andrew fail to get him to stop, Gloria offers to help.
Maggie and Brian are busy doctors. Maggie finds it hard to stop working, while Brian wants time off together. Maggie's mother Rose wants to go to Rome but cannot go alone due to health. Can she convince Maggie and Brian to go with her?
The angels help out a father and son who are having a hard time bonding, and an elderly woman who wants to die so that she may once again be with her husband. Unfortunately, this all is happening at the same time as a potential meteor collision with Earth is headed their way.
Ed is an underpaid businessman, who one day, on his way home from work, just happens to discover a dancer, Marla, trapped in an abandoned mine. With the help of our friendly angel, Andrew, Ed saves Marla by holding a fallen beam in place for over five hours. When rescue personnel arrive, however, they are amazed that Ed held it for so long. Needless to say, he hasn't mentioned Andrew, and he eventually becomes very famous for his good deed. Caught up in the moment, Ed fails to acknowledge Marla's pain when she realizes she has lost her lifelong dream.
Monica becomes a radio assistant to a crude talk show DJ. One of his callers is a depressed young boy who is on verge of committing suicide. The boy calls into radio show for help. The angels must save the boy and the DJ.