Alice is a bitter woman who owns a small store in the lobby of a building. A young boy, Cory, steals a special locket from the store. The angels help find the homeless boy and locket, and find a way to make Alice and Cory a family.
Jason is a teenager who looks up to his ophthalmologist father. Since Jason wants to be a photojournalist, the angels give him a chance to do a photo story on his father. In his photo quest, Jason finds out his father is having an affair.
A rich teenager whose life is laid out for him, is set up when his father has to declare bankruptcy. His plans for Harvard and soccer seem lost when he has to go to a local school with a mediocre soccer team.
Andrew rebels when another angel of death is assigned to a descendant of a long line of people that has previously been his responsibility. Includes many flashbacks to the deaths of people that Andrew has been assigned to.
Monica must try to convince a scientist that creating life from a test tube is not what God intends. The woman is trying to create a child for a Nobel prize, and then realizes she is trying to create someone to love.
A father tries to control his son's life and is obsessed with his baseball performance. The angels help heal the father and son relationship by showing the father he must first heal the relationship he has with his own father.
Tess and the other angels return to a small town to help a woman who is lonely after her boyfriend leaves her. The bartenders in the town remember Tess and decide to help the angels play matchmaker with the woman and a delivery man.
The angels attempt to change the lives of the individuals in a long lost group of friends. Their influences on these people cause them all to end up unexpectedly at the same Polynesian restaurant, where they are surprised to see one another after all of the years that have passed.
A man who died on 9-11-2001 in the twin towers was a music teacher. His death affects one of his students and his family. The student is depressed, his older brother wants to join the army, and their mayor mother has to help the town.