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Some of the celebrity guest stars who have been on the show are Charlie Sheen, Tom Selleck, Sean Penn, Susan Sarandon, Jennifer Grey, Helen Hunt, Jeff Goldblum, Giovanni Ribisi, Debra Jo Rupp, Jane Lynch, Hugh Laurie, Ellen Pompeo, Melissa George, Jason George, Hank Azaria, David Arquette, Billy Crystal, Gary Oldman, Julia Roberts, Reese Witherspoon, Christina Applegate, Jean-Claude Van Damme, Robin Williams, Dakota Fanning, Danny DeVito, Brad Pitt, Kathleen Turner, Cole Sprouse, Anna Faris, Ben Stiller, Paul Rudd, Jon Favreau, Winona Ryder, George Clooney, and Christine Taylor, among many others.
Joey was originally written as a jerk. When Matt LeBlanc questioned why the others would be friends with him, the character was changed.
When Matt LeBlanc auditioned for the role of Joey, he had eleven dollars to his name. When the cast got their first paychecks, the first thing that LeBlanc bought was a hot dinner. Courteney Cox bought a car.
When Courteney Cox dressed as fat Monica for the first time, Matthew Perry walked right past her without recognizing her.
Courteney Cox was originally supposed to play Rachel. In Friends: The Reunion (2021), she explained that she asked to play Monica instead, since she related to her more.
Lisa Kudrow and her best friend wrote "Smelly Cat" one night when they were drunk, and it eventually got written into the show.