Ellen, Paige, and Audrey go to Berkeley for the weekend annual Women Festival and watch Sarah McLaughlin and the Indigo Girls perform. While there, Ellen finds conflicting emotions after visiting a fortune teller who tells her about her future if it will be without Laurie, and a possible relationship with a waitress, named Jean, that they met on the way to the festival. Meanwhile, Paige ponders a commitment to Spence who stays home, and decides to end her romance with him.
Ellen tries to figure out what Laurie is up to on a Saturday after she keeps ignoring questions Ellen asks her during a school show fair for Holly's science project. When Laurie finally tells Ellen about her father passing away, Ellen convinces Laurie to attend the funeral in order to come to terms with her family who shunned her for coming out years ago.
Laurie takes Ellen on a weekend getaway to San Diego where problems arise between them when Laurie's instinct to be organized clashes with Ellen's natural neurotic instinct for spontaneity leading to both of them wanting some space from each other.
Paige and Ellen scheme to have Ellen infiltrate a focus group slated to evaluate a new TV show that Paige developed involving a tall and short cop, and Joe gets in on the act as well. In the meeting room, Ellen successfully convinces the rest of the people present to support the new show for it's first run. But everything changes when Paige meets with Ellen and asks her to support a new show that her boss wants too.
Ellen gets off on the wrong foot with her new neighbors, a immigrant couple from India, named the Patels, when a variety of circumstances conspire to make Ellen look like a fool in front of them which includes Ellen and Paige trying to fix Ellen's leaky roof with a Twister mat, and Ellen struggling with Joe's inflatable doll. But the final humiliation comes when Ellen gets stuck outside her house dressed in a chicken costume before she goes out for the evening with Paige for Joe's birthday party.
While shopping with Ellen at a local hardware store, Spence gets a whiff of an experimental bug spray which sends him into a dream world where homosexuality is the dominant sexuality and heterosexuality is the minority and the oppressed. Ellen and Peter then discover Spence to be a closeted "strait" man in a mostly gay world where Joe is attempting to win his affections, and Paige is a "butch" type involved with Audrey.
Ellen races to the hospital after learning that Laurie was in a serious car accident. While in the waiting room waiting for news on Laurie and waiting for her mother, Lois, to show up with Laurie's daughter, Holly, Ellen chats up a conversation with a strange woman which becomes increasingly heated and tense after Ellen learns that the woman is Karen, Laurie's former girlfriend.
A "mokumentary" hosted by Linda Ellerbee hosts a tribute to a 75-year career of Ellen, which traces her career as a vaudevillian, ventriloquist and hostess of the 1950's game show called "Who's the Commie?" to her show with spoofs from the TV shows 'I Love Lucy', the Dick Van Dyke' and Mary Tyler Moore shows too, as well as interviews with celebrities Jennifer Anniston, Glenn Close, Woody Harrelson, Helen Hunt Ted Danson, Phil Donahue, Tim Conway, and many others.
Disheartened by too much negative response and mistrust in L.A., Ellen's espousal of neighborly behavior inspires listeners of her radio program to be good to one another, including one do-gooder, named Trevor, who catches Paige's eye, as well as increasing business for Joe's coffee shop. But Ellen sees this good deed self-destructing when Trevor begins to annoy Paige with his obsessive kindness, and the people beginning to question the need to do good.
When Ellen's parents, Lois and Harold, decide to renew their wedding vows, Ellen, Paige, and Laurie get thrown into an almost frantic way of planning the wedding to make everything perfect from trying on wedding dresses to Ellen journeying to the po' side of town to find a stripper for Harold's bachelor party. In the midst of all the chaos, Ellen feels she must take the next step in her relationship with Laurie: marriage. But Ellen does not expect the reaction Laurie gives when asked about true commitment.