Dr. Shutt has some difficulty concentrating on his patients after his wife files for divorce. Dr. Geiger agrees to separate conjoined twins, and Dr. Watters ponders suspending the eminent Dr. Thurmond's surgical privileges.
Dr. Geiger clashes with the hospital's executive committee after he performs an experimental procedure on a deceased patient. Dr. Shutt takes on a hapless HMO representative who insists that a less experienced, (and less expensive) surgeon perform a complex operation.
The hospital's administrator dies while "with" Angela. Phillip is made acting administrator. Geiger tries to give a patient, who is waiting for a heart transplant, some more time by giving him the heart of a baboon. Thurmond upon learning that Nyland refuses to treat a woman with AIDS, considers firing him, unless Nyland can convince him not to. Thurmond also decides to use Geiger's baboon to treat the woman with AIDS by transplanting it's bone marrow to her.
Dr. Geiger performs a risky heart operation on an overweight mob killer who's a key witness for the FBI. Two weary residents plot a practical joke to get even with the dour Dr. Geiger. The budding relationship between Dr. Shutt and Dr. Antonovich takes an unexpected turn.
A 12-year-old girl arrives for surgery to correct a severely cleft palate and suffers serious complications from another birth defect. A young nurse interferes in Dr. Shutt's care for the comatose Dr. Antonovich.