| Ally Sheedy | ... | Lori Tanner | |
| Lance Henriksen | ... | Dr. Jarret | |
| Robert Costanzo | ... | Detective Kovacs | |
| Fredric Lehne | ... | Perry | |
| John Cassini | ... | Detective Bendetti | |
| J.D. Daniels | ... | Rudy | |
| William Sanderson | ... | Ray | |
| Trula M. Marcus | ... | Annie | |
| Robin Frates | ... | Judy Sanders | |
| Rick Barker | ... | Mailman | |
| Bradley Pierce | ... | Chet | |
| Robert Arentz | ... | EMAX Security Guard | |
| Cameron Arnett | ... | Dog Catcher #1 | |
| Adam Carl | ... | Dog Catcher #2 | |
| Thomas Rosales Jr. | ... | Mugger | |
| Ray Lykins | ... | KCBG Security Guard | |
| Mickey Cassidy | ... | Paper Boy | |
| Robert Shaye | ... | Mobile Mechanic (as L.E. Moko) | |
| Caroline Cornell | ... | KCBG Receptionist | |
| Del Zamora | ... | Rudy's Dad | |
| Arlen Stuart | ... | Mrs. Barclay | |
| Frank Cavestani | ... | Policeman | |
| Paul Hayes | ... | 2nd Mechanic | |
| Peter Georges | ... | Truck Driver | |
| Olivia Brown | ... | Lab Assistant | |
| Lisa Cavallo | ... | Friday | |
| Frank Welker | ... | Special Vocal Effects (voice) |
Directed by | |||
| John Lafia | |||
Writing credits(WGA) | ||
| John Lafia | (written by) | |
Produced by | |||
| Robert Engelman | .... | producer | |
| Daniel Grodnik | .... | executive producer | |
| Robert Kosberg | .... | executive producer | |
| Kelley Smith-Wait | .... | associate producer | |
Original Music by | |||
| Joel Goldsmith | |||
| Alex Wilkinson | |||
Cinematography by | |||
| Mark Irwin | |||
Film Editing by | |||
| Nancy Frazen | |||
| Michael N. Knue | |||
Casting by | |||
| Valorie Massalas | |||
Production Design by | |||
| Jaymes Hinkle | |||
Art Direction by | |||
| Erik Olson | |||
Set Decoration by | |||
| Ellen Totleben | |||
Costume Design by | |||
| Beverly Hong | |||
Makeup Department | |||
| Mitchell J. Coughlin | .... | makeup effects artist | |
| Aliki Demetriades | .... | hair stylist: Speedy | |
| Aliki Demetriades | .... | makeup artist: Speedy | |
| Suzanne Parker Sanders | .... | hair stylist | |
| Suzanne Parker Sanders | .... | makeup artist | |
| Kevin Yagher | .... | special makeup effects | |
Production Management | |||
| Robert Engelman | .... | unit production manager | |
| Ric Keeley | .... | post-production supervisor | |
| Cindy Lovelady | .... | executive in charge of production (as Cindy Hornickel) | |
Art Department | |||
| Sharon E. Alshams | .... | lead set designer | |
| Scott Edward Collins | .... | set dresser | |
| Tom Craig | .... | set dresser | |
| Anna Czerwatiuk | .... | set dresser | |
| Jonathan Josell | .... | art department coordinator | |
| Christopher Neely | .... | set dresser | |
| Gregory R. Wolf | .... | property master | |
Sound Department | |||
| Gregg Barbanell | .... | foley artist | |
| Jim Brookshire | .... | dialogue editor | |
| Harry Cohen | .... | special sound designer | |
| David Farmer | .... | sound effects editor | |
| William Freesh | .... | sound re-recording mixer | |
| Lewis Goldstein | .... | sound effects editor (as Lew Goldstein) | |
| Tom Hartig | .... | boom operator | |
| Bess Hopper | .... | foley artist | |
| Steve Nelson | .... | sound mixer | |
| Vince Nicastro | .... | foley artist | |
| Ann Scibelli | .... | sound effects editor | |
| Cathie Speakman | .... | dialogue editor | |
| Cathie Speakman | .... | sound editor | |
| Ken Teaney | .... | sound re-recording mixer | |
| Steven D. Williams | .... | supervising sound editor | |
Special Effects by | |||
| Mark R. Byers | .... | special effects assistant | |
| Frank Ceglia | .... | special effects coordinator | |
| Fred Folger | .... | mechanic | |
| Paul H. Haines Jr. | .... | special effects assistant | |
| Greg Aronowitz | .... | special break-away props (uncredited) | |
| Robert Lindores | .... | special effects technician (uncredited) | |
Visual Effects by | |||
| Scott Billups | .... | visual effects | |
| Peter Webb | .... | visual effects | |
Stunts | |||
| Rick Barker | .... | stunt coordinator | |
| Rick Barker | .... | stunts | |
| Bob Black | .... | stunts | |
| Simone Boisseree | .... | stunts | |
| Martin Bresin | .... | stunts | |
| John Cann | .... | stunts (as John Caan) | |
| Frank Ceglia | .... | stunts | |
| Scott Alan Cook | .... | stunts (as Scott Cook) | |
| Jake Crawford | .... | additional stunt coordinator: stunts | |
| Everett Creach | .... | stunts | |
| Justin De Rosa | .... | stunts | |
| David Deleissegues | .... | stunts | |
| Kiante Elam | .... | stunts | |
| Glory Fioramonti | .... | stunts | |
| Mike Johnson | .... | stunts | |
| Donna Keegan | .... | stunts | |
| Clint Lilley | .... | stunts | |
| Jack Lilley | .... | stunts | |
| Mike H. McGaughy | .... | stunts (as Mike McGaughy) | |
| Brian Joseph Moore | .... | stunts | |
| Bobby Porter | .... | stunts (as Bobby M. Porter) | |
| Debby Lynn Ross | .... | stunts | |
| Clint Rowe | .... | stunts | |
| Scott Rowe | .... | stunts | |
| Jerry Wills | .... | stunts | |
| Danny Wynands | .... | stunts (as Dan Wynands) | |
Camera and Electrical Department | |||
| Ron Bahara | .... | first assistant camera: second camera | |
| Matthew J. Curry | .... | additional second assistant camera | |
| John Ditomaso | .... | electrician | |
| Mark Fellman | .... | still photographer | |
| Loren Hillebrand | .... | dolly grip | |
| Dawn Jones | .... | second assistant camera (as Dawn Laurel) | |
| Peter Schmitt | .... | first assistant camera: "b" camera | |
| Charles M. Smallwood | .... | best boy grip | |
| Scott E. Steele | .... | camera operator: "b" camera | |
| Don Telles | .... | grip | |
| Gary Katsuya Ushino | .... | first assistant camera | |
| Troy White | .... | electrician | |
| Jay W. Yowler | .... | gaffer | |
| Phillip Darlington | .... | electrician (uncredited) | |
Editorial Department | |||
| Leigh Davis | .... | assistant film editor | |
| Jill Dole | .... | additional editor | |
| Tzarina V. Edillon | .... | apprentice editor | |
| Joe Fineman | .... | executive in charge of post-production | |
| Lisa Linder | .... | assistant film editor | |
| Vartan Nazarian | .... | editorial apprentice intern | |
| Meghan L. Noble | .... | assistant film editor | |
| Matvey Shatz | .... | color timer | |
Music Department | |||
| Martin Blasick | .... | music producer: "Puppy Love" | |
| Michael Dittrick | .... | music editor | |
Transportation Department | |||
| D.J. Gardiner | .... | driver | |
Other crew | |||
| Keith Bauer | .... | animal trainer | |
| Steve Berens | .... | animal trainer | |
| Bundy Chanock | .... | set medic | |
| Janna Crawford | .... | puppeteer (as Janna Leann Crawford) | |
| David Deleissegues | .... | animal trainer | |
| Melinda Eichberg | .... | animal trainer | |
| Thomas Floutz | .... | puppeteer | |
| Anne E. Hart | .... | production coordinator | |
| Haley McLane | .... | script supervisor: re-shoots | |
| John Palmerton | .... | assistant production coordinator | |
| Jacobus Rose | .... | production executive | |
| Clint Rowe | .... | animal trainer | |
| Scott Rowe | .... | animal trainer | |
| Judith Saunders | .... | script supervisor | |
| Erik Schaper | .... | puppeteer | |
| Frank Schmidt | .... | animal trainer | |
| Russell Shinkle | .... | puppeteer | |
| Steven Shkolnik | .... | location manager | |
| David Stinnett | .... | puppeteer | |
| N. Brock Winkless IV | .... | puppeteer | |
| Marsha Zvonkin | .... | production accountant | |
| Fred Folger | .... | mechanic (uncredited) | |
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| The Island of Dr. Moreau | Man Made Monster | Quarantine | Cujo | Rise of the Planet of the Apes |
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| Full cast and crew | Company credits | External reviews |
| News articles | IMDb Comedy section | IMDb USA section |
"Man's Best Friend", about a genetically altered dog that kills any perceived threat, is pretty much what you'd expect. Ally Sheedy really chews the scenery as the reporter investigating cruelty to animals and inadvertently releasing the bloodthirsty pooch. But no matter, the movie still is pretty fun to watch, with the full understanding that it's basically a totally dumb flick. Lance Henriksen, playing the scientist who created the murderous hound, lets his face do the acting.
Like I said, it's mostly just a fun movie to watch. Definitely nothing special about it. Although I should admit that I'd never heard of a Tibetan mastiff until I read a description of the movie.