The film was made and released about two years after its source play of the same name by Neil Simon was first performed in 1991. The original Broadway production of "Lost in Yonkers" opened at the Richard Rogers Theater on 21st February 1991 and ran for 780 performances until 3rd January 1993. The play was nominated for five 1991 Tony Awards including the Best Play, Best Direction, Best Actress, Best Featured Actor and Best Featured Actress. Mercedes Ruehl and Irene Worth reprise their roles in the movie with Kevin Spacey as Louie, 'Lauren Klein' as Gert, Danny Gerard as Arty, Jamie Marsh as Jay, and 'Mark Blum' as Eddie. The play's setting according to the its intro is: "A two-bedroom apartment over Kurnitz's Kandy Store. Yonkers, NY. 1942".
The character of Johnny (Bella's boyfriend) was an unseen character in the source "Lost in Yonkers" play by Neil Simon. In this film, the character has been realized, and is played by actor David Strathairn.
Playing Jay, this was the only ever theatrical feature film of actor Brad Stoll, who sadly died of cancer at aged only 20 years in 1997. Stoll appeared in one other filmed production, and that was the TV series CityKids (1993).
The movie theatre that flashes "Bijou" on the vertical Marquee is, in reality, the Murphy Theatre on Main Street in Wilmington, Ohio which was one of the shooting locations for the movie. The Murphy is a fully restored 769 seat venue.