After returning the body of Gus McCrae to Lonesome Dove, Woodrow Call takes on the challenge of driving a herd of wild mustangs 2500 miles north to the Hat Creek Ranch in Montana. In his travels, however, Gus will be forced to endure tragedy, triumph, despair and deceit before he ever gets there.
Dunnegan (Oliver Reed) tells Newt (Rick Schroder) he considers him a son; Gideon (William Petersen) confides to Clara (Barbara Hershey) that Agostina (Nia Peeples) is Gus' daughter; Call makes Agostina a partner in the Hat Creek Ranch.
Innocents become caught in the crossfire as the hostilities increase, and Newt Dobbs considers his unlooked-for inheritance before he begins to think about who he should support in the range war that looks increasingly likely to take place. Last in series