Season:
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2
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4
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5
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6
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7
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8
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9
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10
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11
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12
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13
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14
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15
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16
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17
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18
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19
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20
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unknown
Year:
1993
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1994
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1995
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1996
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1997
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1998
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1999
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2000
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2001
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2002
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2003
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2004
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2005
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2006
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2007
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2008
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2009
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2010
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2011
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2012
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2013
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Billy Joel | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tom Brokaw | ... | Himself - Cameo | |
| Miles Kath | ... | Young Lettermen | |
| Paul Newman | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Robin Williams | ... | Himself - Guest | |
| John Mellencamp | ... | Himself - Musical Guest | |
| Jonathan Estrada | ... | Himself (as Jon Estrada) | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Demi Moore | ... | Herself - Guest | |
| Bev Tanner | ... | Herself - Guest | |
| The Spin Doctors | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Scott Rhodes | ... | FBI Agent |
| David Letterman | ... | Himself - Host | |
| Martin Short | ... | Himself - Guest | |
| Cyndi Lauper | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Andy Dick | ... | Donnie (uncredited) |
| David Letterman | ... | Himself - Host | |
| Debra Winger | ... | Herself - Guest | |
| Soul Asylum | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Casey Kasem | ... | Himself - Cameo | |
| Regis Philbin | ... | Himself - Cameo |
| David Letterman | ... | Himself - Host | |
| Richard Lewis | ... | Himself - Guest | |
| Shawn Burroughs | ... | Himself - Guest | |
| Midnight Oil | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Michael J. Fox | ... | Himself | |
| Rosie Perez | ... | Herself | |
| Johnny Petraglia | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Kim Basinger | ... | Herself | |
| Al Gore | ... | Himself | |
| Chris Isaak | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Ellen Barkin | ... | Herself | |
| Lenny Kravitz | ... | Himself | |
| Chris 'Mad Dog' Russo | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Bob Denver | ... | Himself | |
| Roger Ebert | ... | Himself | |
| Robert Plant | ... | Himself | |
| David Sanborn | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Gene Siskel | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Bruno Kirby | ... | Himself - Guest | |
| Harmony Korine | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Van Halen | ... | Himself - Guest |
| David Letterman | ... | Himself - Host | |
| Nicole Kidman | ... | Herself - Guest | |
| Laura Dern | ... | Herself - Guest | |
| Gloria Estefan | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| Paul Shaffer | ... | Himself - Musical Director |
| Jim Dykes | ... | funny Xmas Dad in skits | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Elle Macpherson | ... | Herself - Guest | |
| Vince Vaughn | ... | Himself - Guest | |
| Jewel Kilcher | ... | Herself - Musical Guest (as Jewel) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Robert Borden | ... | Himself - Relating Prom Nightmares | |
| Christian Breheney | ... | Himself - Relating Prom Nightmares | |
| Rupert Jee | ... | Himself - Dramatizing Prom Nightmares | |
| Eric Kaplan | ... | Himself - Relating Prom Nightmares | |
| Rodney Munoz | ... | Himself - Relating Prom Nightmares | |
| Matt Roberts | ... | Himself - Relating Prom Nightmares | |
| Richard Simmons | ... | Himself - Dramatizing Prom Nightmares | |
| Eric Stangel | ... | Himself - Relating Prom Nightmares |
| David Letterman | ... | Himself - Host | |
| Matt Lauer | ... | Himself - Guest | |
| Holiefield Ruthie | ... | Herself - Guest (as Ruthie Bolton-Holifield) | |
| The Mighty Mighty Bosstones | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Pierce Cravens | ... | Young Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Gene Siskel | ... | Himself - Guest (as Siskel) | |
| Roger Ebert | ... | Himself - Guest (as Ebert) | |
| Dermot Mulroney | ... | Himself - Guest | |
| King Charles Troup | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Eric Kaplan | ... | Himself - 'Riverdancing' | |
| Michael Z. McIntee | ... | Himself - 'Riverdancing' (as Mike McIntee) | |
| Gerard Mulligan | ... | Himself - 'Riverdancing' (as Gerry Mulligan) | |
| Jim Peterson | ... | Himself - 'Riverdancing' |
| David Letterman | ... | Himself - Host | |
| Nicholas Turturro | ... | Himself - Guest (as Nick Turturro) | |
| Daisy Fuentes | ... | Herself - Guest | |
| Mötley Crüe | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Francis Dumaurier | ... | Yells at Dave in French |
| David Letterman | ... | Himself - Host | |
| Robert Pastorelli | ... | Himself - Guest | |
| Craig Kilborn | ... | Himself - Guest | |
| Live | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jeff Boggs | ... | Prison Guard (uncredited) | |
| Will Forte | ... | Snow Shovel Murder Victim (uncredited) | |
| Gerard Mulligan | ... | Snow Shovel Murderer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Greg Camp | ... | Themselves - Musical Guest | |
| Harmony Korine | ... | Himself - Guest | |
| Robert Pastorelli | ... | Himself - Guest | |
| Regis Philbin | ... | Himself - Guest | |
| Al Roker | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Kevin Costner | ... | Himself | |
| Tyra Banks | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Brad Daluiso | ... | Himself | |
| Jim Fassel | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Danny Kanell | ... | Himself | |
| Tony Mendez | ... | Himself | |
| Bobby Waldron | ... | Cpt. Ed Smith |
| Tom Hanks | ... | Himself - Guest | |
| Matt Medenweldt | ... | Himself | |
| Scott Weiland | ... | Himself - Musical Guest |
| David Letterman | ... | Himself - Host | |
| Wyclef Jean | ... | Himself - Guest | |
| Harmony Korine | ... | Himself - Guest | |
| Gwyneth Paltrow | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Cher | ... | Herself - Guest / Also Musical Guest | |
| Jerry Springer | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| John Bundy | ... | Himself - Magician | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Tony Mendez | ... | Himself - Drinks a Blue Card | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Uma Thurman | ... | Herself - Guest | |
| Tom Green | ... | Himself - Guest | |
| De La Guarda | ... | Themselves - Musical Guest (as de la Guarda) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Mark Hamill | |
| Corey Feldman | ... | Himself - Cameo | |
| Mel Gibson | ... | Himself - Cameo | |
| Corey Haim | ... | Himself - Cameo | |
| Jerry Springer | ... | Himself - Cameo | |
| Barry White | ... | Himself - Cameo | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| Bobby Waldron | ... | Army Srgt. |
| David Letterman | ... | Himself - Host | |
| Natalie Portman | ... | Herself | |
| Travis Pastrana | ... | Himself | |
| Ted Alexandro | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Justin T. Milner | ... | Himself (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host (credit only) | |
| Janeane Garofalo | ... | Herself - Guest Host | |
| Bob Odenkirk | ... | Himself - Guest | |
| David Cross | ... | Himself - Guest | |
| Zach Galifianakis | ... | Himself - Guest | |
| Old 97's | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director (credit only) |
| David Letterman | ... | Himself - Host | |
| Ringo Starr | ... | Himself - Guest / Musical Guest | |
| Jane Krakowski | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bonnie McFarlane | ... | Herself |
| David Letterman | ... | Himself - Host | |
| Don Rickles | ... | Himself - Guest | |
| Ween | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Madonna | ... | Herself - Guest / Also Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| John McEnroe | ... | Himself - Guest | |
| Youssou N'Dour | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Thora Birch | ... | Herself | |
| Alan Kalter | ... | Himself - Announcer | |
| Dorothy Mengering | ... | Herself |
| David Letterman | ... | Himself - Host | |
| Tom Arnold | ... | Himself - Guest | |
| David Sedaris | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Kenny Bräck | ... | Himself - Playing Guitar |
| David Letterman | ... | Himself - Host | |
| Lance Armstrong | ... | Himself - Guest | |
| Thora Birch | ... | Herself - Guest | |
| Jamie O'Neal | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Dan Rather | ... | Himself - Guest | |
| Regis Philbin | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tori Amos | ... | Herself - Musical Guest | |
| Ayse Eldek | ... | Turkish Woman | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Chris Elliott | ... | Himself - Guest | |
| Eliza Dushku | ... | Herself - Guest | |
| Dixie Chicks | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Presenter (segment "May We See Your Photos - Please?") | |
| Alan Kalter | ... | Himself - Announcer | |
| Michael Zegen | ... | Dwight the Troubled Teen (uncredited) |
| David Letterman | ... | Himself - Host | |
| Maggie Gyllenhaal | ... | Herself - Guest | |
| Pearl Jam | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Terry Buehl | ... | Himself - Top Ten List Presenter (as Captain Terry Buehl) | |
| Richard Clark | ... | Himself - Top Ten List Presenter (as Major Richard Clark) | |
| Pat Farmer | ... | Himself - Reading 'Oprah' Transcript (as Pat) | |
| Dwain Henderson | ... | Himself - Top Ten List Presenter (as Airman First Class Dwain Henderson) | |
| Keith Hurst | ... | Himself - Top Ten List Presenter (as Yeoman First Class Keith Hurst) | |
| Sean Jacques | ... | Himself - Top Ten List Presenter (as Petty Officer Second Class Sean Jacques) | |
| Mike Jaworski | ... | Himself - Top Ten List Presenter (as Corporal Mike Jaworski) | |
| Glenn McAlister | ... | Himself - Top Ten List Presenter (as Staff Sergeant Glenn McAlister) | |
| Jessica Ptacek | ... | Herself - Top Ten List Presenter (as Senior Airman Jessica Ptacek) | |
| Bill Routt | ... | Himself - Top Ten List Presenter (as Major Bill Routt) | |
| Kenny Sheehan | ... | Himself - Reading 'Oprah' Transcript (as Kenny) | |
| Thomas Vantilborg | ... | Himself - Top Ten List Presenter (as Sergeant Thomas Vantilborg) | |
| Anna Jack | ... | Herself - Hula Hooping 'is This Anything?' Participant (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dorothy Mengering | ... | Herself - Annual Thanksgiving Pie Baker | |
| Amy Sedaris | ... | Herself - Guest | |
| The Strokes | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Marv Albert | ... | Himself - Cameo at Dave's Mom's House | |
| Louis J. Aronne | ... | Himself - Clown (as Dr. Lou Aronne) | |
| Brian Cooper | ... | Himself - Top Ten List Presenter (as Engineman Second Class Brian Cooper) | |
| David Gunn | ... | Himself - Top Ten List Presenter (as Lieutenant David Gunn) | |
| Biff Henderson | ... | Himself - Thanksgiving Dinner Guest | |
| Anthony Kyle | ... | Himself - Top Ten List Presenter (as Ensign Anthony Kyle) | |
| Harold Larkin | ... | Harold Larkin - Door Opener | |
| Juan Mendez | ... | Himself - Top Ten List Presenter (as Boatswain's Mate Second Class Juan Mendez) | |
| Anthony Morelli | ... | Himself - Top Ten List Presenter (as Lieutenant Anthony Morelli) | |
| Michael Scott | ... | Himself - Top Ten List Presenter (as Chief Electrician's Mate Michael Scott) | |
| Scott Seevers | ... | Himself - Top Ten List Presenter (as Sonar Technician Second Class Scott Seevers) | |
| Jason Slee | ... | Himself - Top Ten List Presenter (as Mineman Third Class Jason Slee) | |
| Steve Stafford | ... | Himself - Top Ten List Presenter (as Mineman second class Steve Stafford) | |
| Santico Valenzuela | ... | Himself - Top Ten List Presenter (as Ensign Santico Valenzuela) |
| David Letterman | ... | Himself - Host | |
| Allison Janney | ... | Herself - Guest | |
| Martin Scorsese | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Frank Bonsangue | ... | Various comedy skits (uncredited) |
| David Letterman | ... | Himself - Host | |
| Natasha Richardson | ... | Herself - Guest | |
| Mike Birbiglia | ... | Himself - Guest / Stand-up Comedian | |
| David Gray | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Dan Patrick | ... | Himself - Cameo | |
| Frank Bonsangue | ... | Various comedy skits (uncredited) | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Anna Jack | ... | Herself - Hula-Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| John C. Reilly | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Sirajul Islam | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Mujibur Rahman | ... | Himself | |
| Toots Thielemans | ... | Himself - Musical Support | |
| Frank Bonsangue | ... | Various comedy skits (uncredited) | |
| Nadine Hennelly | ... | Herself (uncredited) | |
| Andrea Sande | ... | Herself (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jane Krakowski | ... | Herself - Guest | |
| Jim Boeheim | ... | Himself - Guest | |
| Pete Yorn | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bob Ader | ... | CBS Sports Reporter (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paul Borst | ... | Audience Enhancer | |
| Liam Lynch | ... | Himself - Musical Guest | |
| Tobey Maguire | ... | Himself | |
| Aron Ralston | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Frank Bonsangue | ... | Various comedy skits (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Pete Sampras | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Host | |
| Alan Kalter | ... | Himself - Announcer | |
| Art Kelly | ... | Himself - Survivor of Electric Power Blackout (voice) | |
| Harold Larkin | ... | Harold - Mars Attack Victim | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Spade | ... | Himself - Guest | |
| Bob Sarlatte | ... | Himself - Guest | |
| Maroon 5 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Susan Hum | ... | Herself - Costume Designer | |
| Alan Kalter | ... | Himself - Announcer | |
| Art Kelly | ... | Himself - Survivor of Electric Power Blackout (voice) | |
| Serena Williams | ... | Herself - Top Ten List Presenter | |
| Venus Williams | ... | Herself - Top Ten List Presenter |
| David Letterman | ... | Himself - Host | |
| Dakota Fanning | ... | Herself - Guest | |
| Rocco DiSpirito | ... | Himself - Guest | |
| Idina Menzel | ... | Elphaba | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Travis Bagent | ... | Himself - Late Show Arm Wrestling Championship Contestant | |
| Marcio Barboza | ... | Himself - Late Show Arm Wrestling Championship Contestant | |
| John Brzenk | ... | Himself - Late Show Arm Wrestling Championship Contestant | |
| Leonard Harkless | ... | Himself - World Arm Wrestling Federation Head Referee | |
| Rupert Jee | ... | Himself - Late Show Arm Wrestling Championship Host | |
| Walter O'Neil | |||
| Eric Woelfel | ... | Himself - Late Show Arm Wrestling Championship Contestant | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Steve Martin | ... | Himself - Guest | |
| Shannon Eis | ... | Herself - Presents New Toys for Christmas | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Tony Mendez | ... | Himself - Cue Card Master |
| David Letterman | ... | Himself - Host | |
| Patricia Heaton | ... | Herself - Guest | |
| Kate Bosworth | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Richard Gephardt | ... | Himself - Top Ten List Presenter (as Dick Gephardt) | |
| Alan Kalter | ... | Himself - Announcer | |
| Leslie Moonves | ... | Himself - On the phone with Dave (voice) (as Les Moonves) |
| David Letterman | ... | Himself - Host | |
| Amy Sedaris | ... | Herself - Guest / 4am Tour Guide | |
| Robert Sullivan | ... | Himself - Guest / Rat Expert Author | |
| Modest Mouse | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Robert Borden | ... | Bob - Overslept Staffer | |
| Jimmy Gallagher | ... | Himself - NYPD Officer | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Darian Shannon | ... | Himself - NYPD Officer | |
| Eric Stangel | ... | Eric - Awake Staffer | |
| Michael Z. McIntee | ... | Himself - Breakfast Eater (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Alan Grier | ... | Himself - Guest | |
| Britton Keeshan | ... | Himself - Guest | |
| The Von Bondies | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | George - Hangover Expert | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Gerard Mulligan | ... | President Bill Clinton (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Smith | ... | Himself - Guest | |
| Jet | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Natalie Coughlin | ... | Herself - Guest | |
| Carla Gugino | ... | Herself - Guest | |
| Gavin DeGraw | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Dave Dorsett | ... | Himself - Camera Operator | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Drew Barrymore | ... | Herself | |
| Aron Ralston | ... | Himself |
| Neve Campbell | ... | Herself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Andrew Vannata | ... | Audience Page |
| David Letterman | ... | Himself - Host | |
| Jeff Ament | ... | Himself - Musical Guest | |
| Matt Cameron | ... | Himself - Musical Guest | |
| Stone Gossard | ... | Himself - Musical Guest | |
| Mike McCready | ... | Himself - Musical Guest | |
| Pearl Jam | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| John Travolta | ... | Himself - Guest | |
| Eddie Vedder | ... | Himself - Musical Guest |
| David Letterman | ... | Himself - Host | |
| Howard Dean | ... | Himself - Guest (as Governor Howard Dean) | |
| Franz Ferdinand | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Dorothy Chambers | ... | Herself - Late Show Security Officer (archive footage) | |
| George Clarke | ... | Host of 'It's a Fact' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jamie Foxx | ... | Himself - Guest | |
| Davy Rothbart | ... | Himself - Guest | |
| The Killers | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Adam Sandler | ... | Himself - Guest | |
| Shannon Eis | ... | Herself - Presents New Toys for Christmas | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Annette Guardabascio | ... | Herself - Gives her take on Bernard Kerik | |
| Alan Kalter | ... | Himself - Announcer |
| Brian Donahue | ... | Dad / Alan Kalter Assaulter | |
| Alan Kalter | |||
| David Letterman |
| David Letterman | ... | Himself - Host | |
| Peter Lassally | ... | Himself | |
| Doc Severinsen | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Johnny Carson | ... | Himself (archive footage) | |
| Tommy Newsom | ... | Himself - Musical Support | |
| Ed Shaughnessy | ... | Himself - Musical Support | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Al Franken | ... | Himself - Guest | |
| Matthew Fox | ... | Himself - Guest | |
| Nanci Griffith | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Deion Branch | ... | Himself - Top Ten List Presenter | |
| Troy Brown | ... | Himself - Top Ten List Presenter | |
| Tedy Bruschi | ... | Himself - Top Ten List Presenter | |
| Roosevelt Colvin | ... | Himself - Top Ten List Presenter | |
| Larry Izzo | ... | Himself - Top Ten List Presenter | |
| Ted Johnson | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer | |
| Matt Light | ... | Himself - Top Ten List Presenter | |
| Willie McGinest | ... | Himself - Top Ten List Presenter | |
| Adam Vinatieri | ... | Himself - Top Ten List Presenter | |
| Mike Vrabel | ... | Himself - Top Ten List Presenter | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Smith | ... | Himself - Guest | |
| Tom Brady | ... | Himself - Guest | |
| Biff Henderson | ... | Himself - Visits Superbowl XXXIX | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tully Banta-Cain | ... | Himself - Superbowl XXXIX Player | |
| Matt Chatham | ... | Himself - Superbowl XXXIX Player | |
| Bill Clinton | ... | Himself - Superbowl XXXIX Visitor (as Former President Bill Clinton) | |
| Roosevelt Colvin | ... | Himself - Superbowl XXXIX Player (as Colvin Rosevelt) | |
| Sean Combs | ... | Himself - Superbowl XXXIX Visitor (as Puff Daddy) | |
| Norman Douglass | ... | Himself - Stuntman jumping of roof while on fire | |
| Daniel Graham | ... | Himself - Superbowl XXXIX Player | |
| M.C. Hammer | ... | Himself - Superbowl XXXIX Visitor (as Hammer) | |
| Randy Jackson | ... | Himself - Superbowl XXXIX Visitor | |
| Robert Kraft | ... | Himself - Superbowl XXXIX Visitor | |
| Ashton Kutcher | ... | Himself - Superbowl XXXIX Visitor | |
| Stephen Neal | ... | Himself - Superbowl XXXIX Player | |
| Lionel Richie | ... | Himself - Superbowl XXXIX Visitor | |
| Chris Rock | ... | Himself - Superbowl XXXIX Visitor | |
| Keith Traylor | ... | Himself - Superbowl XXXIX Player |
| David Letterman | ... | Himself - Host | |
| Kevin James | ... | Himself - Guest | |
| Aishwarya Rai Bachchan | ... | Herself - Guest (as Aishwarya Rai) | |
| 3 Doors Down | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Hyde Pierce | ... | Himself - Guest | |
| Howie Day | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Chocolate Referee | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Deborah Lynn | ... | Herself - Intuitive | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Michael Z. McIntee | ... | Seth Garber - Contest Winner (uncredited) |
| David Letterman | ... | Himself - Host | |
| Billy Crystal | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Vernon Campbell | ... | Top Ten Bald Men (voice) (unconfirmed) (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Bill Burr | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Unwritten Law | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Leslie Moonves | ... | Himself (as Les Moonves) | |
| Erica Dahm | ... | Herself - Woman escorting Dr. Phil (uncredited) | |
| Nicole Dahm | ... | Herself - Woman escorting Dr. Phil (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charlie Tschirhart | ... | Himself - Kid Scientist | |
| Robin Peterson | ... | Herself - Kid Scientist | |
| Michelle Ikoma | ... | Herself - Kid Scientist | |
| Keanu Reeves | ... | Himself - Guest | |
| Michael Bublé | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Robert Borden | ... | Himself - Reports from Poconos | |
| Al Chez | ... | Himself - Horn Section Yay-Sayer #2 (uncredited) | |
| Bruce Kapler | ... | Himself - Horn Section Yay-Sayer #3 (uncredited) | |
| Tom Malone | ... | Himself - Horn Section Yay-Sayer #1 (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charlie Sheen | ... | Himself - Guest | |
| Tori Amos | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Drops Things Off Theatre Roof | |
| Robin Frank | ... | Herself - Participant in 'Audience in Show and Tell' | |
| Mark Hankla | ... | Himself - Participant in 'Audience in Show and Tell' (also archive footage) | |
| Rich Meyer | ... | Himself - Participant in 'Audience in Show and Tell' | |
| Stephanie Birkitt | ... | Herself - Hands Out Prizes to Audience (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Roseanne Barr | ... | Herself - Guest / Also Stand-up Comedian (as Roseanne) | |
| Rachel Weisz | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) | |
| Bradford N. Smith | ... | Himself (unconfirmed) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Barbara Walters | ... | Herself - Guest | |
| Rachel Bilson | ... | Herself - Guest | |
| Kings of Leon | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Harold Larkin | ... | Himself - Host of 'Sidewalk Idol' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael J. Fox | ... | Himself | |
| Amanda Bynes | ... | Herself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Bringer of Final Thoughts (as Rupert) | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| John Travolta | ... | Himself - Guest | |
| Tony Kornheiser | ... | Himself - Guest | |
| Michael Wilbon | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Stephanie Birkitt | ... | Herself - Hands Out Prizes to Audience (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ricky Gervais | ... | Himself - Guest | |
| Rachael Ray | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Model for Lego portrait (also archive footage) | |
| Susan Hum | ... | Herself - Unprepared Predictor of Academy Awards (as Sue Hum) | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Nathan Sawaya | ... | Himself - Expert Lego Builder | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dwayne Johnson | ... | Himself - Guest (as The Rock) | |
| Solomon Burke | ... | Himself - Musical Guest | |
| Jay Quinlan | ... | Himself - Jumps with a Snowmobile on 53rd Street | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jimmy Fallon | ... | Himself - Guest | |
| Emily VanCamp | ... | Herself - Guest | |
| The Four Tops | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Mindy Harjo | ... | Herself - Contestant in | |
| Rupert Jee | ... | Himself - Host of 'Guess the Green Puddle' | |
| Mario Vazquez | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amanda Peet | ... | Herself - Guest | |
| Dean Karnazes | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Susan Hum | ... | Herself - Giver of Basketball Picks (as Sue Hum) | |
| Alan Kalter | ... | Himself - Announcer / Various |
| David Letterman | ... | Himself - Host | |
| Jessica Alba | ... | Herself - Guest | |
| Brian Greene | ... | Himself - Guest | |
| Queens of the Stone Age | ... | Themselves - Musical Guest (as Queens Of The Stone Age) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Susan Hum | ... | Herself - Explains the 'String Theory' | |
| Pat Farmer | ... | Himself - Stagehand (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Penélope Cruz | ... | Herself (as Penelope Cruz) | |
| Sarah Vowell | ... | Herself | |
| Kaiser Chiefs | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tony Mendez | ... | Himself - Cue Card Boy | |
| Al Norwood | ... | Himself - Boom Operator | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Drew Barrymore | ... | Herself | |
| Charles Barkley | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Visiting Yankees Spring Training | |
| Derek Jeter | ... | Himself - At Yankees Spring Training | |
| Steve Karsay | ... | Himself - At Yankees Spring Training | |
| Tino Martinez | ... | Himself - At Yankees Spring Training | |
| Mariano Rivera | ... | Himself - At Yankees Spring Training | |
| Alex Rodríguez | ... | Himself - At Yankees Spring Training (as Alex Rodriguez) | |
| Damian Rolls | ... | Himself - At Yankees Spring Training | |
| Mike Stanton | ... | Himself - At Yankees Spring Training | |
| George M. Steinbrenner III | ... | Himself - At Yankees Spring Training (as George Steinbrenner) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Mickey Rourke | ... | Himself | |
| Jason Randal | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Rupert Jee | ... | Himself - Birthday Greeter #4 | |
| Jay Johnson | ... | Himself - Birthday Greeter #3 | |
| Alan Kalter | ... | Himself - Announcer | |
| Sheila Rogers | ... | Herself - Birthday Greeter #2 | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kristin Chenoweth | ... | Herself - Guest | |
| Johnny Lechner | ... | Himself - Guest | |
| Ludacris | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Teddy Sears | ... | Blind Justice (uncredited) |
| David Letterman | ... | Himself - Host (also archive footage) | |
| Amy Sedaris | ... | Herself - Guest | |
| Daniel Tammet | ... | Himself - Guest | |
| LCD Soundsystem | ... | Themselves - Musical Guest (as LCD Sound System) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Paris Hilton | ... | Herself - Previous Littering Guest (archive footage) | |
| Harold Larkin | ... | Presenter of 'Car Tips' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host / Various | |
| Teri Hatcher | ... | Herself - Guest / Various | |
| Harry Hill | ... | Himself - Guest / Stand-up Comedian | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Vinnie Favale | ... | Vinnie Favale / Elvis Presley | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Michael Z. McIntee | ... | Police Officer (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) | |
| Teddy Sears | ... | Blind Justice (uncredited) |
| David Letterman | ... | Himself - Host | |
| Martin Short | ... | Himself - Guest / Also Musical Performer | |
| Elisha Cuthbert | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Leslie Moonves | ... | Himself - Phone Interviewee (voice) (as Les Moonves) | |
| Regis Philbin | ... | Himself - Cameo |
| David Letterman | ... | Himself - Host | |
| Jennifer Lopez | ... | Herself - Guest | |
| Snoop Dogg | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Host of 'May We Shave You for Spring?' | |
| Alan Kalter | ... | Himself - Announcer | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Orlando Bloom | ... | Himself - Guest | |
| Jack Hanna | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Frank McElroy | ... | Presenter of 'Memorable Internship Moment' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Eddie Marrero | ... | Spanish Host (uncredited) |
| David Letterman | ... | Himself - Host | |
| Helen Hunt | ... | Herself - Guest | |
| Tom Dreesen | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Drops Things Off Theatre Roof | |
| Alan Kalter | ... | Himself - Announcer | |
| Al Chez | ... | Himself - Horn Section Yay-Sayer #2 (uncredited) | |
| Bruce Kapler | ... | Himself - Horn Section Yay-Sayer #3 (uncredited) | |
| Tom Malone | ... | Himself - Horn Section Yay-Sayer #1 (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Billy Crystal | ... | Himself - Guest | |
| Garbage | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Stephanie Birkitt | ... | Herself - Hands Out 'Show and Tell' Prizes (as Vicky) | |
| Molly Carrigan | ... | Herself - 'Audience Show and Tell' participant | |
| Brian Donahue | ... | Brian the Alan Kalter Assaulter | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Charles Kopelman | ... | Himself - 'Audience Show and Tell' participant (also archive footage) | |
| Barry Willey | ... | Himself - 'Audience Show and Tell' participant |
| David Letterman | ... | Himself - Host | |
| Samuel L. Jackson | ... | Himself | |
| Sting | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Frank McElroy | ... | Presenter of 'Memorable Internship Moment | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host (also archive footage) | |
| Ray Romano | ... | Himself - Guest (also archive footage) | |
| Dave Matthews Band | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Robert Borden | ... | Himself - Aspiring Actor / Various (as Bob Borden) | |
| Rawleigh Moreland | ... | Himself - Acting Teacher (as Rawley Moreland) | |
| C. Andrew Nelson | ... | Darth Vader | |
| David Acord | ... | Darth Vader / Jango Fett / Imperial Guard (voice) (uncredited) | |
| James Doherty | ... | Red Guard (uncredited) | |
| Rupert Jee | ... | Himself - Hello Deli Owner (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Peter Mayhew | ... | Chewbacca / Top Ten List Presenter (uncredited) | |
| Matthew Wood | ... | Stormtrooper / Darth Maul / C-3P0 (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paul Newman | ... | Himself - Guest | |
| Danica Patrick | ... | Herself - Guest | |
| Adam Savage | ... | Himself - Guest | |
| Jamie Hyneman | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Katie Holmes | ... | Herself - Guest | |
| Bill Scheft | ... | Himself - Bumped Guest (credit only) | |
| Shout Out Louds | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Brian Collins | ... | Himself - 'Boom Goes The Dynamite' Guy | |
| Crystal Frommert | ... | Herself - Audience Show and Tell Participant | |
| Rupert Jee | ... | Himself - Slurpy Vendor | |
| Bud Moeller | ... | Himself - Audience Show and Tell Participant | |
| Stephanie Birkitt | ... | Vicky - Hands Out 'Show and Tell' Prizes (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jennifer Capri | ... | Telemundo Annoyed Woman | |
| Al Franken | ... | Himself | |
| Ellen Pompeo | ... | Herself | |
| Teddy Sears | ... | Batman | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Mark Wahlberg | ... | Himself - Guest | |
| Juan Pablo Montoya | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Host of 'What's in the Green Room?' | |
| Alan Kalter | ... | Himself - Announcer | |
| Sid McGinnis | ... | Himself - 'Will It Float' Expert | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Julian McMahon | ... | Himself - Guest | |
| Raul Midon | ... | Himself - Musical Guest | |
| Kyle Nelson | ... | Himself - Piedmont Bird Caller | |
| Matt Matier | ... | Himself - Piedmont Bird Caller | |
| Andrew Almeida | ... | Himself - Piedmont Bird Caller | |
| Andrew Meyer | ... | Himself - Piedmont Bird Caller | |
| Becca Backer | ... | Herself - Piedmont Bird Caller | |
| Casey Rogers | ... | Himself - Piedmont Bird Caller | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Frozen Fruit Whippy Vendor | |
| Alan Kalter | ... | Himself - Announcer | |
| Deborah Lynn | ... | Herself - Psychic Intuitive | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tom Brokaw | ... | Himself - Guest | |
| Dakota Fanning | ... | Herself - Guest (also archive footage) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| David Adamovich | ... | Himself - The Great Throwdini (as The Great Throwdini) | |
| Susan Hum | ... | Late Show Bear Fighter | |
| Harold Larkin | ... | Moon Escapee | |
| Ula | ... | Herself - Ula The Pain-Proof Rubber Girl | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jennifer Connelly | ... | Herself - Guest | |
| The Eels | ... | Themselves - Musical Guest (as Eels) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| E.J. Becker | ... | Himself - 'Stump the Band' Challenger | |
| Peter 'Pete' Fatovich | ... | 'Late Show Bear' Caretaker (as Pete Fatovich) | |
| Eileen Hancy | ... | Herself - 'Stump The Band' challenger | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Bruce Kapler | ... | Himself - 'Stump the Band' Contestant | |
| Will Lee | ... | Himself - 'Stump the Band' Contestant | |
| Tony Mendez | ... | Tony - Spanish 'War of the Worlds' Spoiler'er | |
| Bob Stanhope | ... | Himself - 'Stump the Band' Challenger | |
| Stephanie Birkitt | ... | Vicky - Hands Out 'Show and Tell' Prizes (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael Chiklis | ... | Himself - Guest | |
| Gary Mule Deer | ... | Himself - Guest / Performs Stand-up Comedy | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Shannon Eis | ... | Herself - Presenting New Summer Toys | |
| Biff Henderson | ... | Himself - Drives a Go-Kart | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| John Cusack | ... | Himself - Guest | |
| The All-American Rejects | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | George Clarke - Tour De France analyst | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Harold Larkin | ... | Harold Larkin - Heat Beater | |
| Valerie Shepard | ... | Herself - Late Show Bear Care Taker | |
| Darrin Bennett | ... | Lance Armstrong (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kelly Preston | ... | Herself - Guest | |
| Jeff Altman | ... | Himself - Guest | |
| Aimee Mann | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Himself - Egg Frier | |
| Alan Kalter | ... | Himself - Announcer | |
| Jason Kirschner | ... | 'Late Show Bear' Caretaker |
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest / Various | |
| Bettye LaVette | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Kyle J. Bogert | ... | Rent-A-Son | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Dennis Murphy | ... | Himself - 'Know Your Current Events' Participant (as Captain Dennis Murphy) | |
| Regis Philbin | ... | 'Late Show Bear' Caretaker | |
| Becky Turner | ... | Herself - 'Know Your Current Events' Participant | |
| Stephanie Birkitt | ... | Vicky (uncredited) |
| David Letterman | ... | Himself - Host | |
| Lance Armstrong | ... | Himself | |
| Michael Ian Black | ... | Himself | |
| Son Volt | ... | Themselves (credit only) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Elvis Costello | ... | 'Late Show Bear' Caretaker | |
| Biff Henderson | ... | Himself - Hang'er Out'er | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Marcia Cross | ... | Herself - Guest | |
| Jeff MacGregor | ... | Himself - Guest | |
| Lucinda Williams | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Wax Celebrity Identifier | |
| Stephanie Montague | ... | 'Late Show Bear' Caretaker | |
| Pat Farmer | ... | Himself - Stagehand (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Gene Szymanski | ... | Himself - Stagehand (uncredited) |
| Nick Cirillo | ... | Himself | |
| Paul Reiser | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Spoon | ... | Themselves - Musical Guest |
| Stephen Colbert | ... | Himself | |
| Heloise | ... | Herself | |
| The Black Eyed Peas | ... | Themselves | |
| Paul Shaffer | ... | Himself - Musical Director |
| David Letterman | ... | Himself - Host | |
| Claire Danes | ... | Herself - Guest | |
| Big Boi | ... | Himself - Musical Support | |
| Purple Ribbon All-Stars | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | George - Delivers a 'Thanksgiving Safety Tip' | |
| Zak George | ... | Himself - Owner of 'Stupid Pet Trick' dog 'Venus' | |
| Barbara Giacobe | ... | Herself - Owner of 'Stupid Pet Trick' dog 'Riot' | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Robert Mundell | ... | Himself - Teller of Rodney Dangerfield's jokes | |
| Chelsea Ron | ... | Herself - Owner of 'Stupid Pet Trick' dogs 'Flyer' - 'Basil', and 'Luna' | |
| Janet Ron | ... | Herself - Owner of 'Stupid Pet Trick' dogs 'Flyer' - 'Basil', and 'Luna' |
| David Letterman | ... | Himself - Host | |
| Tatum O'Neal | ... | Herself - Guest | |
| Jeff MacGregor | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Performs a Pizza Taste-off | |
| Alan Kalter | ... | Himself - Announcer | |
| Rute | ... | Herself - Late Show Model | |
| Andrea Sande | ... | Herself - Late Show Model | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Beckinsale | ... | Herself | |
| Bob Saget | ... | Himself | |
| Sarah Schreiber | ... | Lauri S. | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Philip Seymour Hoffman | ... | Himself - Guest | |
| Paul Teutul Jr. | ... | Himself - Guest | |
| Paul Teutul Sr. | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Stephanie Birkitt | ... | Herself | |
| Pat Farmer | ... | Himself - Stagehand | |
| Biff Henderson | ... | Himself - Stage Manager Modelling for Cheese Sculpture | |
| Troy Landwehr | ... | Himself - Sculpturing Biff Henderson in cheese | |
| Michael Teutul | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Tim Russert | ... | Himself - Guest | |
| Henri Arnold | ... | Himself - Guest | |
| Cat Power | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Stagehand Causing Light to Flicker | |
| Teenie Hodges | ... | Himself - Sitting in with the band for musical support on guitar | |
| Rupert Jee | ... | Himself - Kicking Footballs from Roof |
| David Letterman | ... | Himself - Host | |
| Dwyane Wade | ... | Himself - Guest | |
| Amy Sedaris | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bruce Kapler | ... | Himself - Signs for a Package | |
| Morningwood | ... | Themselves - Musical Guest | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Colin Farrell | ... | Himself - Guest | |
| India.Arie | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Shannon Eis | ... | Herself - Presents New Summer Toys | |
| Susan Hum | ... | Herself - Costume Designer | |
| Rupert Jee | ... | Himself - Host's 'What's on the Ipod?' | |
| Darrin Bennett | ... | Floyd Landis (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Maria Sharapova | ... | Herself - Guest | |
| Martha Stewart | ... | Herself - Guest | |
| Justin Timberlake | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tony Mendez | ... | Himself - Cue Card Boy | |
| Johnny Dark | ... | Rude Dude (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ashton Kutcher | ... | Himself - Guest | |
| Sam Hornish Jr. | ... | Himself - Guest | |
| TV on the Radio | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Stagehand | |
| Alan Kalter | ... | Himself - Announcer | |
| Susan Aileen Cremin | ... | Cheerleader (uncredited) | |
| Johnny Dark | ... | Doctor (uncredited) | |
| Mark Delabarre | ... | Various Characters (uncredited) | |
| Stephen Seidel | ... | Basketball Player (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dwayne Johnson | ... | Himself - Guest (as Dwayne 'The Rock' Johnson) | |
| Norm MacDonald | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jeff Burton | ... | Himself - Top Ten List Presenter | |
| Kyle Busch | ... | Himself - Top Ten List Presenter | |
| Dave Dorsett | ... | Himself - Camera Operator | |
| Dale Earnhardt Jr. | ... | Himself - Top Ten List Presenter | |
| Jeff Gordon | ... | Himself - Top Ten List Presenter | |
| Denny Hamlin | ... | Himself - Top Ten List Presenter | |
| Kevin Harvick | ... | Himself - Top Ten List Presenter | |
| Rupert Jee | ... | Himself - Host's 'What's on the Ipod?' | |
| Jimmie Johnson | ... | Himself - Top Ten List Presenter | |
| Kasey Kahne | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer | |
| Matt Kenseth | ... | Himself - Top Ten List Presenter | |
| Mark Martin | ... | Himself - Top Ten List Presenter | |
| Johnny Dark | ... | Mets Fan (uncredited) | |
| Mary Ann Hannon | ... | Dave's Diner Waitress (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Anne Heche | ... | Herself - Guest | |
| Luke R. Ravenstahl | ... | Himself - Guest (as Luke Ravenstahl) | |
| The Who | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jude Brennan | ... | Herself - Producer in Cold Open Sketch (as Jude) | |
| Susan Hum | ... | Herself - Brings in a Cat | |
| Art Kelly | ... | Art - Switchboard Operator | |
| Ricardo Cordero | ... | Bob Zicks (uncredited) | |
| Johnny Dark | ... | Frustrated Remote Control Owner (uncredited) | |
| Mary Ann Hannon | ... | Dave's Diner Waitress (uncredited) |
| David Letterman | ... | Himself - Host | |
| Johnny Knoxville | ... | Himself - Guest | |
| Rachael Ray | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Tommy O'Brien | ... | Himself - Stage Hand | |
| Johnny Dark | ... | Tailor (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Frank Caliendo | ... | Himself - Guest | |
| Rachael Harris | ... | Herself - Guest | |
| Xzibit | ... | Himself - Musical Guest | |
| Phil Pfister | ... | Himself - Flips a car on 53rd Street | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Rachel Weisz | ... | Herself - Guest | |
| David Rakoff | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Morningwood | ... | Themselves |
| David Letterman | ... | Himself - Host | |
| Kate Winslet | ... | Herself - Guest | |
| Tom Waits | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Ross Talkington | ... | Basketball Player | |
| Susan Aileen Cremin | ... | Cheerleader (uncredited) | |
| Mark Delabarre | ... | Various Characters (uncredited) | |
| Stephen Seidel | ... | Basketball Player (uncredited) |
| Brian Donahue | ... | Alan Kalter Assaulter | |
| David Letterman | |||
| Donal Logue | ... | Himself | |
| Marc Maron | ... | Himself | |
| Julianne Moore | ... | Herself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Martin Short | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Matt Lauer | ... | Himself - Guest | |
| Artie Lange | ... | Himself - Guest | |
| Augustana | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer |
| Penélope Cruz | ... | Herself | |
| Brian Donahue | ... | Alan Kalter Assaulter | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | |||
| Ben E. King | ... | Himself | |
| David Letterman | |||
| Gary Mule Deer | ... | Himself (as Gary Muledeer) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Julianne Moore | ... | Herself - Guest | |
| Madonna | ... | Herself - Guest | |
| The Hold Steady | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tom Catusi | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Ricky Gervais | ... | Himself - Guest | |
| Forest Whitaker | ... | Himself - Guest | |
| The Shins | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Himself - Building Engineer | |
| Rupert Jee | ... | Himself - Trying Out Pantsuits | |
| Alan Kalter | ... | Himself - Announcer | |
| Teresa Lo | ... | Spiderman in Jamba Juice (uncredited) |
| David Letterman | ... | Himself (credit only) | |
| Adam Sandler | ... | Himself - Guest Host | |
| Don Cheadle | ... | Himself | |
| Danica Patrick | ... | Herself | |
| Todd Barry | ... | Himself - Guest Comic | |
| Lucinda Williams | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director |
| Dinosaur Jr. | ... | Themselves | |
| Kirsten Dunst | ... | Herself | |
| Rob Magnotti | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Michael Maniaci | ... | Himself- Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tobey Maguire | ... | Himself - Guest | |
| John Byner | ... | Himself - Guest / Impressionist | |
| Modest Mouse | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Topher Grace | ... | Himself | |
| Biff Henderson | ... | Himself - Host's 'What's on the Ipod?' | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Tom Catusi | ... | Himself - Sleeping Videotape Editor (uncredited) | |
| Ricardo Cordero | ... | Bob Zicks (uncredited) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself | |
| Darlene Love | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Brian Donahue | ... | Brian the Alan Kalter Assaulter | |
| Alan Kalter | |||
| Austin Williams | ... | Boy Seeking Alan's Autograph (uncredited) |
| David Letterman | ... | Himself - Host | |
| Don Rickles | ... | Himself - Guest | |
| Michael Imperioli | ... | Himself - Guest | |
| Wilco | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Kenny Bräck | ... | Himself - Playing Guitar | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Masi Oka | ... | Himself - Top Ten List Presenter | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Luke Wilson | ... | Himself - Guest | |
| Rufus Wainwright | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Susan Hum | ... | Herself - 'Know Your Current Events' (as Sue) | |
| Stephanie Birkitt | ... | Herself - Hands Out Prizes to Audience (uncredited) | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ellen Barkin | ... | Herself - Guest | |
| Brian Regan | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Gene Szymanski | ... | Glen Murphy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin James | ... | Himself - Guest | |
| José Andrés | ... | Himself - Guest | |
| White Rabbits | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Kyle Duncan | ... | Himself - New York Pastry Chef | |
| Alan Kalter | ... | Himself - Announcer | |
| Tony Mendez | ... | Himself - Presenting 'How It's Made' | |
| Mark Odgers | ... | Himself - Jumping Over a Taxi on 53rd Street | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin Bacon | ... | Himself - Guest | |
| Dalton Carriker | ... | Himself - Guest | |
| T.I. | ... | Himself - Musical Guest | |
| Wyclef Jean | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Hosting 'Psychic Soup' | |
| Deborah Lynn | ... | Herself - Playing 'Psychic Soup' | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Clinton | ... | Himself - Guest (as President Bill Clinton) | |
| Patti Scialfa | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Brian Donahue | ... | Secret service agent | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Danny DeVito | ... | Himself - Guest | |
| Larry David | ... | Himself - Guest | |
| Avril Lavigne | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Himself | |
| Susan Hum | ... | Herself | |
| Johnny Dark | ... | Mark Twain (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jessica Alba | ... | Herself - Guest | |
| George Saunders | ... | Himself - Guest | |
| The Manchester Orchestra | ... | Themselves - Musical Guest (as 'Manchester Orchestra') | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Ronald Reagan dressed as Abraham Lincoln (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rachael Ray | ... | Herself - Guest | |
| Frank Rich | ... | Himself - Guest | |
| Arctic Monkeys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Aaron Bing | ... | Himself - Trying to break the world record in 'Circular Breathing' with a saxophone | |
| Stuart Claxton | ... | Himself - Guinnes World Records Judge | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jodie Foster | ... | Herself - Guest | |
| Glen Hansard | ... | Himself - Musical Guest | |
| Markéta Irglová | ... | Herself - Musical Guest (as Marketa Irglova) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Himself - Building Engineer | |
| Dave Dorsett | ... | Himself - Camera Operator | |
| Biff Henderson | ... | Himself - Giving Back-to-School Advice | |
| Susan Hum | ... | Herself - Costume Designer | |
| Rupert Jee | ... | Himself - Giving Back-to-School Advice | |
| Alan Kalter | ... | Himself - Announcer | |
| Gary Mintz | ... | Himself - Technical Maintenance Supervisor Giving Back-to-School Advice | |
| Johnny Dark | ... | Mark Twain (uncredited) | |
| Karen Weatherwax | ... | French Tutor for Dave Dorsett (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Andy Kindler | ... | Himself - Guest | |
| Suzanne Vega | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Deborah Lynn | ... | Herself - Playing 'Psychic Sandwich' | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Viggo Mortensen | ... | Himself - Guest | |
| Katherine von Drachenberg | ... | Herself - Guest (as Kat Von D) | |
| Daughtry | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Clint Bowyer | ... | Himself - Top Twelve List Presenter | |
| Jeff Burton | ... | Himself - Top Twelve List Presenter | |
| Kurt Busch | ... | Himself - Top Twelve List Presenter | |
| Kyle Busch | ... | Himself - Top Twelve List Presenter | |
| Carl Edwards | ... | Himself - Top Twelve List Presenter | |
| Jeff Gordon | ... | Himself - Top Twelve List Presenter | |
| Denny Hamlin | ... | Himself - Top Twelve List Presenter | |
| Kevin Harvick | ... | Himself - Top Twelve List Presenter | |
| Jimmie Johnson | ... | Himself - Top Twelve List Presenter | |
| Matt Kenseth | ... | Himself - Top Twelve List Presenter | |
| Tony Stewart | ... | Himself - Top Twelve List Presenter | |
| Martin Truex Jr. | ... | Himself - Top Twelve List Presenter | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Martha Stewart | ... | Herself - Guest | |
| Fred Willard | ... | Himself - Guest | |
| Maya Arulpragasam | ... | Herself - Musical Guest (as M.I.A.) | |
| Billy Bob Thornton | ... | Himself - Top Ten List Presenter | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Johnny Dark | ... | Mark Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| Chamillionaire | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) | |
| Slick Rick | ... | Himself - Musical Guest (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jamie Foxx | ... | Himself - Guest | |
| Jimmy Smits | ... | Himself - Guest | |
| Will i Am | ... | Himself - Musical Guest (as Will.I.Am) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Mary Apple | ... | Herself - Audience Member with Heart-Shaped Potato | |
| Jon Coombs | ... | Himself - Putting Rubberbands Over His Head | |
| Darrin Bennett | ... | Floyd Landis (uncredited) | |
| George Clarke | ... | Himself - Building Engineer (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Walsh | ... | Herself - Guest | |
| Kevin Smith | ... | Himself - Guest | |
| Rascal Flatts | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Bill Scheft | ... | Himself - Writer |
| David Letterman | ... | Himself - Host | |
| Jennifer Garner | ... | Herself - Guest | |
| Ken Burns | ... | Himself - Guest | |
| Chaka Khan | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Chris Elliott | ... | Himself - Promoting 'Bionic Guy' | |
| Gerard Mulligan | ... | Himself - Promoting 'Bionic Guy' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Stewart J. Zully | ... | Hoodlum (uncredited) |
| David Letterman | ... | Himself - Host | |
| Whoopi Goldberg | ... | Herself - Guest | |
| Melissa Etheridge | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jason Winn 'J.B. Destiny' Bareford | ... | Himself - Performing 'Stupid Human Tricks' | |
| Chris Hansen | ... | Himself - Performing 'Stupid Human Tricks' | |
| Mark Hayward | ... | Himself - Performing 'Stupid Human Tricks' | |
| Rupert Jee | ... | Himself - Dressed as 'Ugly Betty' |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Emile Hirsch | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Henry Rife | ... | Himself - Jumping over six taxicabs on an ATV |
| David Letterman | ... | Himself - Host | |
| Sean Penn | ... | Himself - Guest | |
| Barry Sonnenfeld | ... | Himself - Guest | |
| Ben Harper | ... | Himself - Musical Guest | |
| The Innocent Criminals | ... | Themselves - Musical Guests | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Brian Teta | ... | Himself - Segment Producer / Sharing his 'Memories of Regis' | |
| Dave Dorsett | ... | Himself - Camera Operator (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jude Law | ... | Himself - Guest | |
| Sarah Silverman | ... | Herself - Guest | |
| John Fogerty | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Sarah Billington | ... | Herself - Talent Coordinator / Sharing her 'Memories of Regis' | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Mark 'Johnny' Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Alec Baldwin | ... | Himself - Guest | |
| Faith Hill | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Anagnostakos | ... | Himself - Writers' Intern | |
| Stephanie Hearn | ... | Herself - Talent Intern |
| David Letterman | ... | Himself - Host | |
| Nicollette Sheridan | ... | Herself - Guest | |
| Tony Snow | ... | Himself - Guest | |
| Rihanna | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Chris Elliott | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Gerard Mulligan | ... | Himself - Plugging 'Skink, The Bounty Hunter' |
| David Letterman | ... | Himself - Host | |
| Bob Newhart | ... | Himself - Guest | |
| Angela Kinsey | ... | Herself - Guest | |
| Iron & Wine | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Gary Mintz | ... | Himself - Technical Maintenance Supervisor Sharing His 'Memories of Regis' | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| George Clooney | ... | Himself | |
| Kid Rock | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Celebrating Columbus Day by Throwing Things Off Theater Roof | |
| Kenny Sheehan | ... | Himself - Helping Pat Throw Things Off Theater Roof | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jennifer Lopez | ... | Herself - Guest / Musical Guest | |
| Alan Greenspan | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager Presenting 'What's in the Green Room?' | |
| Al Norwood | ... | Himself - Boom Operator | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Stephen Colbert | ... | Himself - Guest | |
| Eva Mendes | ... | Herself - Guest | |
| Queens of the Stone Age | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Pat Farmer | ... | Himself - Stagehand Bringing in Box of Meat from Gallagher's (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alex Rodríguez | ... | Himself - Getting a bare-chested rubdown from Biff Henderson (archive footage) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Anne Heche | ... | Herself - Guest | |
| Sue Johanson | ... | Herself - Guest | |
| Mariza | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Johnny Dark | ... | Vince - Crescent Springs Village Sales Representative (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Bill Scheft | ... | Himself - Writer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Halle Berry | ... | Herself - Guest | |
| Bill Hader | ... | Himself - Guest | |
| Eric Buss | ... | Himself - Performing Comedy Magic Act (as Spring Snake Symphony) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Dave Dorsett | ... | Himself - Camera Operator (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) | |
| Karen Weatherwax | ... | Santa Maria (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jake Gyllenhaal | ... | Himself - Guest | |
| Connie Britton | ... | Herself - Guest | |
| 50 Cent | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| George Clarke | ... | Himself - Building Engineer | |
| Megan Dougherty | ... | Herself - Intern | |
| Tyler Flowers | ... | Himself - Intern | |
| Jessica Holohan | ... | Herself - Intern | |
| Carrie Kemper | ... | Herself - Intern | |
| Phil Kessel | ... | Himself - Intern | |
| Anne McCarthy | ... | Herself - Intern | |
| Michael Z. McIntee | ... | Security Guard | |
| Mark Odgers | ... | Himself - Jumping Over 5 Interns on 53rd Street | |
| Dan Fetter | ... | Fleeing Guy Chased by Security Guard (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Tony Yayo | ... | Himself - Musical Guest (uncredited) |
| David Letterman | ... | Himself - Host | |
| Richard Simmons | ... | Himself - Guest | |
| Casey Affleck | ... | Himself - Guest | |
| Sondre Lerche | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| José Feliciano | ... | Himself - Surprise Musical Guest / Performing 'Old Turkey Buzzard' | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Dave Dorsett | ... | Himself - Camera Operator (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rebecca Romijn | ... | Herself - Guest | |
| Jimmie Walker | ... | Himself - Guest | |
| LeAnn Rimes | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Bill Scheft | ... | Himself - Writer | |
| Johnny Dark | ... | Johnny D (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Susan Hum | ... | Herself (uncredited) |
| David Letterman | ... | Himself - Host | |
| Steve Carell | ... | Himself - Guest | |
| Chris 'Mad Dog' Russo | ... | Himself - Guest (as Christopher 'Mad Dog' Russo) | |
| Band of Horses | ... | Themselves - Musical Guest | |
| Chris Elliott | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Gerard Mulligan | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amanda Peet | ... | Herself - Guest | |
| Patrick Warburton | ... | Himself - Guest | |
| Jeff Caldwell | ... | Himself - Guest / Stand Up Comedy Routine | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Susan Hum | ... | Herself (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jerry Seinfeld | ... | Himself - Guest | |
| Joe Torre | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Bill Scheft | ... | Himself - Writer |
| David Letterman | ... | Himself - Host | |
| Jennifer Connelly | ... | Herself - Guest | |
| Slash | ... | Himself - Guest | |
| Nicole Atkins | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Johnny Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Spade | ... | Himself - Guest | |
| Jonathan Papelbon | ... | Himself - Guest | |
| Penn Jillette | ... | Himself - Magical Performer (as Penn) | |
| Teller | ... | Himself - Magical Performer | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Johnny Dark | ... | Johnny - Cold Open Sketch (uncredited) | |
| Biff Henderson | ... | Skunk Eater (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Ryan Adams | ... | Himself - Musical Guest (as Ryan Adams and The Cardinals) | |
| The Cardinals | ... | Themselves - Musical Guest (as Ryan Adams and The Cardinals) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Joren Hodel | ... | Himself - 'Stupid Pet Tricks' Dog Owner | |
| Alan Kalter | ... | Himself - Announcer | |
| Willie Machado | ... | Himself - 'Stupid Pet Tricks' Dog Owner | |
| Bill Scheft | ... | Himself - Writer | |
| Irena Schulz | ... | Herself - 'Stupid Pet Tricks' Cockatoo Owner | |
| Lucia Vasquez | ... | Herself - 'Stupid Pet Tricks' Dog Owner | |
| Jude Brennan | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Jay-Z | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| George Vlosich | ... | Himself - Etch-A-Sketch Artist |
| David Letterman | ... | Himself - Host | |
| Robin Williams | ... | Himself - Guest | |
| Lupe Fiasco | ... | Himself - Musical Guest / Featuring Matt Santos | |
| Tim Carvell | ... | Himself - Top Ten List Presenter | |
| Laura Krafft | ... | Herself - Top Ten List Presenter | |
| Melissa Salmons | ... | Herself - Top Ten List Presenter | |
| Warren Leight | ... | Himself - Top Ten List Presenter | |
| Jay Katsir | ... | Himself - Top Ten List Presenter | |
| Steve Bodow | ... | Himself - Top Ten List Presenter | |
| Nora Ephron | ... | Herself - Top Ten List Presenter | |
| Gina Gionfriddo | ... | Herself - Top Ten List Presenter | |
| Chris Albers | ... | Himself - Top Ten List Presenter | |
| Alan Zweibel | ... | Himself - Top Ten List Presenter | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Nancy Agostini | ... | Herself - Guest | |
| Ron Buttler | ... | Himself - Questions to Dave | |
| Hal Gurnee | ... | Himself - Presenting 'Hal Gurnee's Network Timekiller' | |
| Angelo Iodice | ... | Himself - Performing 'Dance of the Boleadoras' | |
| Una Mimnagh | ... | Herself - Performing 'Dance of the Boleadoras' | |
| Lisa Rime | ... | Herself - Questions to Dave | |
| Matthew Santos | ... | Himself - Musical Support (as Matt Santos) | |
| Patricia Scalize | ... | Herself - Questions to Dave | |
| Bill Scheft | ... | Late Show Strike Captain | |
| Hillary Rodham Clinton | ... | Herself - Pre-taped Cold Open Welcome (uncredited) | |
| Brian Donahue | ... | Brian the Alan Kalter Assaulter (uncredited) | |
| Biff Henderson | ... | Himself - Disruptive Staffer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Alan Kalter | ... | Assault Victim (uncredited) | |
| Walter Kim | ... | Scott Iha (uncredited) | |
| Brian Teta | ... | Attorney Jim Jackoway (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Maher | ... | Himself - Guest | |
| Ellen Page | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Michael Bloomberg | ... | Himself - Awarding the Key to the City to Dave's Beard | |
| Hal Gurnee | ... | Himself - Presenting 'Hal Gurnee's Network Timekiller' | |
| Roger Bart | ... | Dr. Frederick Frankenstein - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Christopher Fitzgerald | ... | Igor - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Sutton Foster | ... | Inga - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Donald Trump | ... | Himself | |
| Shooter Jennings | ... | Himself - Musical Guest | |
| Sarah Billington | ... | Herself - Guest / Talent Co-ordinator | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tom Hanks | ... | Himself - Guest | |
| Mike Huckabee | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Roberto Patane | ... | Himself - Barber Shaving Dave | |
| Diane Wood | ... | Herself - Barber Shaving Dave | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Lucy Liu | ... | Herself - Guest | |
| Alexander Roy | ... | Himself - Guest (as Alex Roy) | |
| MGMT | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bill Medley | ... | Himself - Sitting in with the band | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Morgan Freeman | ... | Himself - Guest | |
| Tom Brokaw | ... | Himself - Guest | |
| Chuck Prophet | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Goose Gossage | ... | Himself - Presenting the Top Ten List | |
| Rupert Jee | ... | Himself - Presenting 'What's Rupert's Soup of the Day?' Segment | |
| John McCain | ... | Himself - Pre-taped segment / 'Late Show Candidate Spotlight' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Howard Stern | ... | Himself - Guest | |
| Ayo | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Chris Elliott | ... | Himself - Taking a Break from Picketing | |
| John McCain | ... | Himself - 'Late Show Candidate Spotlight' | |
| Gerard Mulligan | ... | Himself - Taking a Break from Picketing | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Beth Ostrosky | ... | Herself - Green Room Cameo (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tracy Morgan | ... | Himself - Guest | |
| Katherine von Drachenberg | ... | Herself - Guest (as Kat Von D) | |
| Dropkick Murphys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Anna Jack | ... | Herself - Hula-Hoop Girl | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Katie Holmes | ... | Herself - Guest | |
| Frank Caliendo | ... | Himself - Guest | |
| Maroon 5 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Adam Levine | ... | Himself | |
| James Valentine | ... | Himself | |
| Pat Farmer | ... | Himself - Stagehand Bringing in Pizza for Three Guys in Audience (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer / Scratching a Lottery Ticket (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) | |
| Al Norwood | ... | Himself - Boom Operator (uncredited) |
| David Letterman | ... | Himself - Guest | |
| Denzel Washington | ... | Himself - Guest | |
| Don Rickles | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Harold Larkin | ... | Himself - Hailing a cab with a dead guy on an office chair (as Harold) | |
| Michael Z. McIntee | ... | Himself - Hailing a cab with a dead guy on an office chair (as Mike) | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael Douglas | ... | Himself - Guest | |
| Katherine Heigl | ... | Herself - Guest | |
| Wyclef Jean | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Gary Mintz | ... | Himself - Electronic Maintenance Engineer Performing 'Gary-oke with Gary Mintz' | |
| Pat Farmer | ... | Himself - Stagehand (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Sylvester Stallone | ... | Himself - Guest | |
| Paul Teutul Jr. | ... | Himself - Guest (as 'The Teutuls') | |
| Paul Teutul Sr. | ... | Himself - Guest (as 'The Teutuls') | |
| The Mars Volta | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Spinning the 'Late Show Prize Wheel' | |
| Alan Kalter | ... | Himself - Announcer | |
| Bruce Willis | ... | Himself - Sitting in with the band |
| Jim Gaffigan | ... | Himself | |
| Diane Keaton | ... | Herself |
| David Letterman | ... | Himself - Host | |
| Sarah Michelle Gellar | ... | Herself - Guest | |
| Dan Patrick | ... | Himself - Guest | |
| Ringo Starr | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Bruce Willis | ... | Himself - Pre-taped 'Bruce Willis Secret Word of the Night' segment | |
| Tracey B. Wilson | ... | Sketch Comedian | |
| David A. Stewart | ... | Himself - Musical Support / Guitar Player for Ringo Starr (uncredited) |
| David Letterman | ... | Himself - Host | |
| John Edwards | ... | Himself - Guest (as Senator John Edwards) | |
| Diablo Cody | ... | Herself - Guest | |
| Josh Ritter | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| David 'Fathead' Newman Jr. | ... | Himself - Sitting in with the band | |
| Tom Catusi | ... | Himself - Late Show Video Operator (uncredited) | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Rupert Jee | ... | Himself (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charles Grodin | ... | Himself - Guest | |
| Lawrence Tynes | ... | Himself - Guest | |
| The Redwalls | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Julia Louis-Dreyfus | ... | Herself - Guest | |
| T.J. Miller | ... | Himself - Guest | |
| Super Furry Animals | ... | Themselves - Musical Guest | |
| Barack Obama | ... | Himself - Top Ten List Presenter (as Senator Barack Obama) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Zohar Adner | ... | Himself - Stress Release Coach | |
| Donna Barnes | ... | Herself - Life and Relationship Coach | |
| Allan Fried | ... | Himself - Career Coach | |
| Judith Ann Graham | ... | Herself - Image Coach and Personal Stylist | |
| Andy Kindler | ... | Himself - Guest | |
| Mark Schwimmer | ... | Himself - Personal Development Facilitator | |
| Pat Farmer | ... | Himself - Stagehand (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Nathan Lane | ... | Himself - Guest | |
| Jake Johannsen | ... | Himself - Guest / Stand-up Comedy Routine | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bill Scheft | ... | Himself - Writer | |
| Bruce Willis | ... | Himself - Pre-taped / Presenting 'Bruce Willis Secret Word of the Night' segment | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jessica Alba | ... | Herself - Guest | |
| Julie Chen | ... | Herself - Guest | |
| The Whigs | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Rupert Jee | ... | Himself - Supporting the WGA Strike | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Johnny Dark | ... | Himself - Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Cosby | ... | Himself - Guest | |
| Lake Bell | ... | Herself - Guest | |
| The Matt Savage Trio | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Lena Headey | ... | Herself - Guest | |
| Gary Allan | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Eva Longoria | ... | Herself - Guest (as Eva Longoria Parker) | |
| Colbie Caillat | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Kyle Campbell | ... | Himself - Performing 'Stupid Human Tricks' | |
| Bradley Cheney | ... | Himself - Talking during 'Technical Maintenance Minute' (as Brad) | |
| Steve Hostomsky | ... | Himself - Talking during 'Technical Maintenance Minute' (as Steve) | |
| Scott Jacobson | ... | Himself - Performing 'Stupid Human Tricks' | |
| Gary Mintz | ... | Himself - Talking During 'Technical Maintenance Minute' (as Gary) | |
| Duncan Stephens | ... | Himself - Performing 'Stupid Human Tricks' | |
| Damon Warren | ... | Himself - Performing 'Stupid Human Tricks' | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Artie Lange | ... | Himself - Guest | |
| Vampire Weekend | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Tony Mendez | ... | Himself - Cue Card Boy in 'How It's Made' Segment | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Hillary Rodham Clinton | ... | Herself - Guest (as Senator Hillary Clinton) | |
| Sheryl Crow | ... | Herself - Musical Guest | |
| Biff Henderson | ... | Himself - Reporting from the Super Bowl in Arizona | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tom Coughlin | ... | Himself - Being Interviewed by Biff Henderson at the Super Bowl | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Matthew McConaughey | ... | Himself - Guest | |
| Gary Mule Deer | ... | Himself - Guest | |
| Sheryl Crow | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Eli Manning | ... | Himself - Guest | |
| Vince Vaughn | ... | Himself - Guest | |
| Alison Sudol | ... | Herself - Musical Guest (as A Fine Frenzy) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Blake Benitez | ... | Kid 2008 | |
| Tony Mendez | ... | Goat Herder on 'Que Pasa USA!' | |
| Jude Brennan | ... | Dave's Wife (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Hudson | ... | Herself - Guest | |
| Jack Hanna | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Bob Clark | ... | Himself - Reptile Expert | |
| Stephanie Birkitt | ... | Herself - Handing Out Prizes to Audience (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Colin Farrell | ... | Himself - Guest | |
| Blake Lively | ... | Herself - Guest | |
| Lenny Kravitz | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Susan Hum | ... | Herself - Hands Out Dave's Suits (as Sue) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Walsh | ... | Herself - Guest | |
| Jason Sudeikis | ... | Himself - Guest | |
| OK Go | ... | Themselves - Musical Guest | |
| Bonerama | ... | Themselves - Musical Guest (as OK Go and Bonerama) | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager Interviewing Audience Member | |
| Alan Kalter | ... | Himself - Announcer (voice) (as Alan) | |
| Phil McGraw | ... | Himself (as Dr. Phil) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Evangeline Lilly | ... | Herself - Guest | |
| Marisa Miller | ... | Herself - Guest | |
| Brad Paisley | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Tom Catusi | ... | Himself - Late Show Video Operator | |
| George Clarke | ... | Himself - Looking at Billboard (as George) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Michael Z. McIntee | ... | Cover Model for 'Mustache Aficionado Magazine' (uncredited) |
| David Letterman | ... | Himself - Host | |
| Martin Short | ... | Himself - Guest | |
| Amy Ryan | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (as Jude) | |
| Chris Elliott | ... | Himself / Bedlam - Plugging the New Show 'American Conquistadors' | |
| Howard Hersh | ... | Himself - Musical Timpanist / Supporting Martin Short's Musical Act as Timpanist on the Kettle Drum | |
| Phil McGraw | ... | Himself (archive footage) (as Dr. Phil) | |
| Gerard Mulligan | ... | Himself - Plugging the New Show 'American Conquistadors' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| Joseph Arthur | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Santiago Archila | ... | Himself - Audience Member participating in 'Audience Show & Tell' (also archive footage) | |
| Nelson Dudley | ... | Himself - Audience Member participating in 'Audience Show & Tell' | |
| Alan Kalter | ... | Himself - Announcer / Hosting 'Alan Kalter's Celebrity Interview' | |
| Andrea Lo | ... | Herself - Audience Member participating in 'Audience Show & Tell' | |
| Stephanie Birkitt | ... | Herself - Handing Out Prizes to Audience (uncredited) | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charles Barkley | ... | Himself - Guest | |
| Bill Burr | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dennis Quaid | ... | Himself | |
| Ryan Newman | ... | Himself | |
| Sharon Jones | ... | Herself - Musical Guest | |
| The Dap-Kings | ... | Themselves - Musical Guests | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Johnny Dark | ... | Johnny Lincoln (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Randy Jackson | ... | Himself - Guest | |
| Saffron Burrows | ... | Herself - Guest | |
| Ray Davies | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Interviewing Audience Members | |
| Sid McGinnis | ... | Himself - Late Show Band Guitarist: Displaying New Beard Style (as Sid) | |
| Bill Scheft | ... | Himself - Late Show Writer | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amy Sedaris | ... | Herself - Guest | |
| Erika Jensen | ... | Herself - Guest | |
| Foo Fighters | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Biff Henderson | ... | Himself - Stage Manager Starting Grocery Bagging Contest (as Biff) | |
| Kid Rock | ... | Himself - Appearing in 'Paul Shaffer's Rock of Love' Segment | |
| Emeril Lagasse | ... | Himself - Top Ten List Presenter | |
| Martha Stewart | ... | Herself - Top Ten List Presenter | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gary Mintz | ... | Raul Castro - Calling Dave on the Phone (uncredited) (voice) | |
| Karen Weatherwax | ... | Marci - Girl in 'Paul Shaffer's Rock of Love' Segment (uncredited) |
| David Letterman | ... | Himself - Host | |
| Steve Martin | ... | Himself - Guest | |
| Chris Elliott | ... | Himself - Guest Plugging 'Chris and Gerry's Kitchen Nightmares' | |
| Raymond Crowe | ... | Himself - Performing Guest / Hand Shadow Magician | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Francis Dumaurier | ... | Manager at Le Bernardin in 'chris and Gerry's Kitchen Nightmares' | |
| Mary Goggin | ... | Hostess | |
| Mark Guthrie | ... | Himself - Current Events Segment Participant | |
| Gerard Mulligan | ... | Himself - Surprise Guest Plugging 'Chris and Gerry's Kitchen Nightmares' | |
| Eric Ripert | ... | Himself - Executive Chef at Le Bernardin in 'Chris and Gerry's Kitchen Nightmares' | |
| Stephanie Birkitt | ... | Herself - Handing Out Prizes to Audience (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Gary Mintz | ... | Raul Castro (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Sean Combs | ... | Himself - Guest (as Sean 'Diddy' Combs) | |
| Al Lubel | ... | Himself - Comedian | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Victoria Lilly | ... | Herself - Paul Shaffer's Daughter | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Ferrell | ... | Himself - Guest | |
| Michael McDonald | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Robert Borden | ... | Himself - Writer | |
| Alan Kalter | ... | Himself - Announcer | |
| Brian Donahue | ... | Brian the Alan Kalter Assaulter (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Peyton List | ... | Von Trapp Kid (uncredited) | |
| Gary Mintz | ... | Raul Castro - On the Phone with Dave (uncredited) (voice) | |
| Scarlett Sperduto | ... | Von Trapp Kid (uncredited) | |
| Jaclyn Tommer | ... | Von Trapp Kid Singing with Will Ferrell (uncredited) |
| David Letterman | ... | Himself - Host | |
| Courteney Cox | ... | Herself - Guest | |
| Thomas Friedman | ... | Himself - Guest | |
| Chingy | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Ray Benson | ... | Himself - Musical Support | |
| Ludacris | ... | Himself - Musical Support for Chingy | |
| Bobby V | ... | Himself - Musical Support for Chingy (as Bobby) | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Gary Mintz | ... | Raul Castro - On the Phone with Dave (uncredited) (voice) | |
| Richard Scheckman | ... | Contest Winner Wearing a Red Dress (uncredited) |
| David Letterman | ... | Himself - Host | |
| Natalie Portman | ... | Herself | |
| Kenna | ... | Himself - Musical Guest | |
| Pharrell Williams | ... | Himself - Musical Support | |
| Chad Hugo | ... | Himself - Musical Support | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Louis J. Aronne | ... | Himself - Medical Doctor: Andy Kindler at Toy Fair '08 | |
| Lisa R. Callahan | ... | Herself - Medical Doctor: Andy Kindler at Toy Fair '08 (as Lisa Callahan) | |
| Kristen French | ... | Herself - Kid Scientist | |
| Andy Kindler | ... | Himself - At Toy Fair '08 | |
| Sam Mather | ... | Himself - Kid Scientist | |
| James Murray | ... | Himself - Audio Engineer: Andy Kindler at Toy Fair '08 (as Jim Murray) | |
| Victor Wang | ... | Himself - Kid Scientist |
| David Letterman | ... | Himself - Host | |
| Amy Adams | ... | Herself - Guest | |
| Jamie Oliver | ... | Himself - Guest | |
| Liam Finn | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Hillary Rodham Clinton | ... | Herself - Special Message (as Hillary Clinton) | |
| Scot Haney | ... | Himself - Meteorologist / Telling Dave about the upcoming weather report | |
| Jude Brennan | ... | Herself - Executive Producer Telling Dave About the Guests (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy Getting Sprayed with Water by Dave (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Woody Harrelson | ... | Himself - Guest | |
| Tommy Tiernan | ... | Himself - Guest / Stand-up Comedy Routine | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jim Carrey | ... | Himself - Guest | |
| Paula Abdul | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Dave Dorsett | ... | Himself - Camera Operator (as Dave) | |
| Pat Farmer | ... | Himself - Stagehand Spinning 'Late Show Prize Wheel' (as Pat) | |
| Alan Kalter | ... | Himself - Announcer (as Alan) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Gary Mintz | ... | Gov. Eliot Spitzer - Talking to Dave on the phone (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Martha Stewart | ... | Herself - Guest | |
| Snoop Dogg | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Lauren Reeves | ... | Spitzer's Girlfriend | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charlize Theron | ... | Herself - Guest | |
| Lewis Black | ... | Himself - Guest | |
| British Sea Power | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Al Chez | ... | Himself - CBS Orchestra: Trumpet | |
| Alan Kalter | ... | Himself - Announcer | |
| Natalie Pero | ... | Mobster's Girlfriend | |
| Gerard Mulligan | ... | Eliot Spitzer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Beckinsale | ... | Herself - Guest | |
| Graham Colton | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Doug Benefield | ... | Himself - Professional Turkey Gobbler | |
| George Clarke | ... | Himself - Building Engineer | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Stephan Richardson | ... | Himself - Professional Turkey Gobbler | |
| Scott Wilhelm | ... | Himself - Professional Turkey Gobbler | |
| Johnny Dark | ... | Johnny Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jaime Pressly | ... | Herself - Guest | |
| Brian Regan | ... | Himself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Karen Weatherwax | ... | Mom in 'Dave's Store' | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rainn Wilson | ... | Himself - Guest | |
| Mike Golic | ... | Himself - Guest | |
| Mike Greenberg | ... | Himself - Guest | |
| Bell X1 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Al Franken | ... | Himself - Guest | |
| Lauren Conrad | ... | Herself - Guest | |
| The Cribs | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Rupert Jee | ... | Himself - Hosting 'What's In The Soup?' Contest | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Brooke Shields | ... | Herself | |
| Seth Meyers | ... | Himself | |
| The Gutter Twins | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Dave Dorsett | ... | Himself - Camera Operator (as Dave) | |
| Alan Kalter | ... | Himself - Announcer | |
| Jamie Bamber | ... | Lee Adama - Top Ten Presenter (uncredited) | |
| James Callis | ... | Gaius Baltar - Top Ten Presenter (uncredited) | |
| Aaron Douglas | ... | Galen Tyrol - Top Ten Presenter (uncredited) | |
| Tricia Helfer | ... | Number Six - Top Ten Presenter (uncredited) | |
| Michael Hogan | ... | Saul Tigh - Top Ten Presenter (uncredited) | |
| Lucy Lawless | ... | D'anna Biers - Top Ten Presenter (uncredited) | |
| Mary McDonnell | ... | Laura Roslin - Top Ten Presenter (uncredited) | |
| Edward James Olmos | ... | William Adama - Top Ten Presenter (uncredited) | |
| Grace Park | ... | Lt. Sharon Valerii - Top Ten Presenter (uncredited) | |
| Katee Sackhoff | ... | Kara Thrace - Top Ten Presenter (uncredited) |
| David Letterman | ... | Himself - Host | |
| Demi Moore | ... | Herself - Guest | |
| Anthony Bourdain | ... | Himself - Guest | |
| Counting Crows | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Jude Brennan | ... | Herself - Executive Producer in Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Bosworth | ... | Herself - Guest | |
| John Witherspoon | ... | Himself - Guest | |
| The Raveonettes | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Brian Williams | ... | Himself - Guest | |
| Judy Greer | ... | Herself - Guest | |
| Langhorne Slim | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Helen Mirren | ... | Herself - Guest | |
| Jose Canseco | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Joba Chamberlain | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Billy Crystal | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Shelley Duncan | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Joe Girardi | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Biff Henderson | ... | Himself - Visiting Yankees Spring Training | |
| Derek Jeter | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Alan Kalter | ... | Himself - Announcer | |
| Mickey Rivers | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Alex Rodríguez | ... | Himself - Attending New York Yankee's spring traning in Tampa (as Alex Rodriguez) | |
| José Veras | ... | Himself - Attending New York Yankee's spring traning in Tampa (as Jose Veras) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| John McCain | ... | Himself - Guest (as Sen. John McCain) | |
| Cat Power | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Thomas Beatie | ... | Himself - Top 10 List | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| George Clooney | ... | Himself | |
| Norah Jones | ... | Herself | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Renée Zellweger | ... | Herself - Guest (as Renee Zellweger) | |
| Gayle King | ... | Herself - Guest | |
| Paddy Casey | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Pat Farmer | ... | Himself - Stagehand Dropping Baseballs from Theatre Roof Dressed as New York Yankee | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ellen Pompeo | ... | Herself - Guest | |
| Jay-Z | ... | Himself - Guest / Also Musical Guest | |
| Mary J. Blige | ... | Herself - Guest / Also Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Al Pacino | ... | Himself - Guest | |
| David Wright | ... | Himself - Guest | |
| Trevor Immelman | ... | Himself - Presenting the Top Ten List | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Dave Dorsett | ... | Himself - Camera Operator (as Dave) | |
| Alan Kalter | ... | Himself - Announcer (voice) |
| David Letterman | ... | Himself - Host | |
| Kelsey Grammer | ... | Himself - Guest | |
| Kristen Bell | ... | Herself - Guest | |
| Rogue Wave | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| William Bregman | ... | Himself - Top Ten List Presenting Accountant | |
| Saundra Bussel | ... | Herself - Top Ten List Presenting Accountant | |
| Richard Cohen | ... | Himself - Top Ten List Presenting Accountant | |
| Lou DeFalco | ... | Himself - Top Ten List Presenting Accountant | |
| Arthur Drucker | ... | Himself - Top Ten List Presenting Accountant | |
| Steven Goldstein | ... | Himself - Top Ten List Presenting Accountant | |
| Alan Kalter | ... | Himself - Announcer | |
| Richard Koenigsberg | ... | Himself - Top Ten List Presenting Accountant | |
| Vicki Penino | ... | Herself - Top Ten List Presenting Accountant | |
| Andrew Ross | ... | Himself - Top Ten List Presenting Accountant | |
| Andrew Rubin | ... | Himself - Top Ten List Presenting Accountant | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Gerard Mulligan | ... | Master Artist - Painting a Presidential Portrait (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Uma Thurman | ... | Herself - Guest | |
| Graham Rahal | ... | Himself - Guest | |
| The Gossip | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Gary Mintz | ... | Gary Mintz - Technical Engineer Superhero Who Saves the Day | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gerard Mulligan | ... | Friend of President John Adams (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kelly Ripa | ... | Herself - Guest | |
| John Holdren | ... | Himself - Guest | |
| The Black Keys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Jude Brennan | ... | Herself - Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amy Poehler | ... | Herself - Guest | |
| Jason Segel | ... | Himself - Guest | |
| Jordan Zevon | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| Alan Kalter | ... | Himself - Announcer | |