Daphne complains about her mother's pushiness in planning her wedding. Frasier makes a Freudian slip that leads her to think that he and Martin are offering to pay for her wedding, which she joyfully accepts. Before long, Frasier becomes even more domineering than her mother. Niles, depressed about Daphne's impending nuptials, decides to try a dating service and is elated to be matched with an attractive blonde named Sabrina. But Frasier learns from Donny that the service in question is actually a call girl ring.
Frasier is repeatedly made the butt of phone pranks by KACL's new comedy team, "Carlos and the Chicken." When the team announces a contest for a covert photo of Frasier's hindquarters, he decides to retaliate by composing an oration, a move ridiculed by his family and friends.
After losing his job at KACL, Bulldog is delivering pizzas. Seeing how well he gets along with Alice, Roz offers him a job as a babysitter. After a while, she finds that he is driving away her dates so he can declare his own feelings for her. Martin, pressured by his sons, makes arrangements for his own burial.
No one at the station can stand the owner's airhead daughter, Poppy, but Niles finds himself taken with her. Frasier finds a half-naked woman in his apartment, and she introduces herself as his new neighbor. Both brothers start dating, but a misunderstanding leads both of them to conclude that they are competing for the same woman.
The rift between Martin and his sons' tastes is bridged when they find they are all fans of "The Antique Roadshow." The boys have a great time watching it on TV, and when the Roadshow comes to Seattle, they all go. Martin takes along an old family heirloom, a rather ugly pewter clock. Frasier and Niles are stunned to hear that it was originally made for the Romanovs (the Russian royal dynasty). Believing the clock is a link to their own royal blood, Frasier and Niles launch an investigation into its origins.
A minor fender-bender sends Frasier to the hospital. While waiting, Niles hears the name of Maris's plastic surgeon, Mel Karnofsky, and decides to confront him about a billing error. An annoying man bores Frasier into leaving the office, and the man uses Frasier's name to jump the line. Niles is surprised to find that Mel is actually a woman, with whom he has a lot in common. The man at the hospital dies suddenly, and Frasier is mistakenly thought dead for a day. He takes it as a wake-up call, doing his best to live live to the fullest every day. Niles doesn't have ...
Lilith and Frederick come to Seattle for Thanksgiving dinner with the Cranes. Frederick maneuvers Frasier and Lilith into spending an evening together, and they begin to suspect that he is trying to get them back together. Or is he just trying to guilt them into buying him a moped?
On his birthday, Frasier is seized with crippling back pain. Niles wonders if he's stressed, and while recovering at home, Frasier muses aloud about why he's unhappy. One reason is that he's still single, and he will miss Daphne's companionship after she gets married. Daphne, overhearing, misunderstands him to mean that he has feelings for her. Frasier resolves the confusion, but while he's doped up on painkillers, lets slip to Daphne the truth about Niles's feelings for her.
Daphne is unsure how to deal with Niles's feelings for her. Roz assures her there's nothing to worry about: Niles has a girlfriend now, and she's engaged to Donny. However, Niles has a meeting with Maris to console her over the loss of a friend, a meeting that he keeps secret from Mel. Frasier lets slip the secret, and Mel angrily breaks up with Niles, making Daphne very nervous. Frasier's Christmas party competes with one thrown by his rival neighbor, Cam Winston.
Frasier tells Roz about his family's adventure on the Millenial New Year... Chez Henri, where they planned to spend it, burned down, so they drove toward Sun Valley in Martin's Winnebago, for a party thrown by a wine club friend. Hijinks ensue en route, starting when a drowsy Niles boards the wrong Winnebago at a truck stop.
At Cafe Nervosa, Frasier runs into his unrequited high school crush and former prom queen, Lorna Lynley (Smart). The courtship gives Frasier a chance to live up the high school glory days that he never had.
Frasier plans to introduce himself to a beautiful woman he has seen at the opera, but brings Martin along to the opera so as not to look lonely. The woman's mother takes a shine to Martin, and he pretends to be gay to deflect her advances. Frasier makes his overture, and Emily comes to his apartment for a nightcap, bringing along her uncle, Edward, as a date for Martin.
When Roz takes a vacation, Frasier hires Mary, a producer fresh out of of training, to fill in for the week. Soon, Mary starts taking over Frasier's show, but Frasier is hesitant to say anything because she's black. Meanwhile, Niles shows off his new kick-boxing skills with disastrous results.
Frasier begins to think that Niles' new girlfriend may be slightly manipulative, a suspicion that is brought to the forefront when Niles suddenly announces he wants to run against Frasier to be the prestigious Corkmaster of their wine club.
Frasier and Roz share a room at a broadcasting conference, which is notorious for being a meet market. However, both strikeout miserably and return to the room dejected. The combined effects of both their recent dating dry spells and their respective new looks (Frasier has beard stubble and Roz tries on a blonde wig) cause them to seek each other for companionship. Martin takes on a stakeout job at Donny's request, but Niles has his concerns.
Frasier's show is pulled off the air for a week, supposedly to give a new talk show a try, but Frasier has figured out the real reason: leverage against him in his contract negotiations with the station. Thinking two can play that game, Bebe lines up a one-week guest spot on AM Seattle, a morning TV talk show, for him and Roz. When Roz shows up on Monday with a raging fever, Bebe steps in as his co-host. They're such a hit that the TV station wants them on a permanent basis, which fame-struck Bebe desperately wants while Frasier wrestles with decision. Meanwhile, ...
Frasier learns that comely neighbor Regan Shaw has recently become available again, but is shy about approaching her because his previous encounters with her resulted in him looking foolish. Meanwhile, Donnie is looking for someone to organize his bachelor party, but balks when Frasier offers, due to his stuffy perception. Out to prove he can be "just one of the guys", Frasier auditions a stripper for the event, only to become handcuffed to her. Unable to get them off, he desperately tries to hide his predicament from both Daphne, who is against a raunchy bachelor ...
Part One of Two. Daphne's wedding is approaching and Niles becomes even more apprehensive when he and Mel decide to take a trip together. He feels it is too early in the relationship to go away with her but, after a therapy session with Frasier, decides to take the risk. While the two are away, Daphne finally tells Frasier that she may have feelings for Niles. Upon his return, much to the shock of the rest of the family, Niles announces that he and Mel eloped and are now husband and wife, leaving Daphne devastated.
Part Two of Two. It is the night before Daphne and Donny's wedding and her entire family, as well as Frasier, Martin, Roz and Niles have arrived at the Wayside Inn, where the wedding is to take place. As much as he tries, Niles realizes that he is nowhere near over Daphne at all and he decides to lay it all on the line and tell Daphne how he feels once and for all.