Roz is unsatisfied with her new job, and comes back to KACL, acting as though nothing has changed. Frasier believes her attachment is based on deep attraction to him stemming from their one-night stand. Roz disabuses him of this notion, and they go back to being friends. Recalling that he once donated sperm, Niles returns to the bank to see whether it was ever used, and is told that he suffers from low motility. He tries a variety of weird medical remedies.
After breaking up with Julia, Frasier lapses into his usual self-pitying funk. Niles reminds him that he has a fear of commitment that leads him to sabotage all his relationships with women. Frasier typically overdoes things, committing to commitment with Julia, even during an evening with his family when she rubs everyone the wrong way, and steps on Niles and Daphne's surprise announcement that she is pregnant.
Suspecting that Roz's new boyfriend is secretly gay, Frasier follows him and inadvertently winds up in a gay bar. Before long, the rest of Seattle considers him "outed." The news actually improves his friendship with Alistair Burke, the director of the Seattle Opera. Drunk with status, Frasier tries to ignore the obvious implications.
Frasier decides to resume private practice. While shopping for a suitable couch, he and Niles catch sight of Ronee Lawrence, their old babysitter. Frasier invites her for a drink, but it quickly becomes apparent that she is interested in Martin.
Roz sets Frasier up with her friend, Ann, advising Frasier that he should keep his dating skills in shape, even if it means going out with someone he's not interested in. Frasier agrees, but their first date is a night in Hell, made worse by the fact that Kenny is dining in the same restaurant with his attractive and eminently suitable cousin. Niles and Daphne have a fastidious cleaning lady whom Niles adores, but Daphne believes is stealing.
Frasier inadvertently eavesdrops on Ronee making a date with another man. Martin takes the news badly, accusing him of spying and inventing a fictitious girlfriend to spark Ronee's jealousy. Niles tries win the attention of a reclusive nursery painter.
Maris meets with Niles, seeking protection from her violent new boyfriend. Because of Daphne's mood swings, Niles tries to keep his meeting secret, which fails when the boyfriend shows up at a fake baby shower and punches Frasier. Frasier's first day back in private practice goes less smoothly than he hoped.
Maris is arrested for the murder of her boyfriend. The press goes wild when they find out that Niles inadvertently loaned her the crossbow that was used as the murder weapon. Niles slowly goes to pieces under the unrelenting media scrutiny and Daphne's anger.
Lilith is in town for a psychiatric conference, and Frasier reluctantly assumes his obligation to meet with her. Before he does so, an interested colleague of Lilith's sets him up on a blind date with her, not knowing who he really is. Martin's pistol accidentally discharges inside the apartment, creating a trail of destruction that he, Daphne and Niles try to hide from Frasier.
For once, Niles is the famous one, as media attention to Maris's case makes him and Daphne the center of Seattle's attention. Frasier is left to contemplate his falling ratings and his dating woes. In a funk, he agrees to emcee the SeaBea Awards and give an interview to a newspaper reporter, neither of which goes well. Roz seethes during a visit from her "perfect" sister, Denise.
Frederick visits Frasier in Seattle, and the family is shocked to see him going through a "Goth" phase. The family talks about the rebellious phase of a child's life, and Niles is stung to hear Martin say that he was always one of the good kids. He decides to rebel by consuming a pot brownie supplied by Roz, but hijinks ensue when Martin eats it.
Ann Hodges grudgingly agrees to assess Frasier's apartment for a home insurance quote; when she falls and breaks her leg, he decides to take her in and buddy her up, afraid she will sue. Maris is released from jail but kept under house arrest; she draws Niles, Martin, and Daphne into an elaborate scheme to escape the country.
Martin and Ronee's romantic getaway to the country is spoiled when first Frasier, and then Niles and Daphne mistakenly believe they have been invited along. At the cabin, each of them has a nightmare based on their hidden fears: Frasier dreams that he has killed Niles and married Daphne; Niles that he is unable to handle a baby; and Daphne that Niles is cheating on her while she gains weight uncontrollably. Only Martin has a peaceful dream, seeing himself and Ronee at the center of a music hall routine.
Through a series of unnecessarily detailed flashbacks, Frasier confesses to Niles that, bored with his job and jealous of his family's happiness, he has stolen a small trinket from an elderly neighbor's apartment. He and Niles crash her surprise birthday party to try and return it in secret.
Exiting the elevator on the wrong floor of his office building, Frasier runs into Charlotte, a matchmaker looking eagerly for new clients. Frasier declines her help, but changes his mind after a disastrous encounter with an ex-girlfriend. His confidence does not improve when Charlotte sends him on a series of dates from hell. An impressionable Niles and Daphne follow the advice of another couple from their Lamaze class, and hire a midwife who insists on a drug-free birth.
Frasier is taken with Charlotte, but she already has a boyfriend, a ruggedly handsome man named Frank. To try and get his mind off her, Roz takes him to a singles bar, where he meets a sexy and eager young woman named Kim. Martin tries to make a good impression on Ronee's very conservative mother.
Charlotte has to go to a conference and Frasier offers to drive her to the train station. However, they miss the train (numerous times at numerous stations) and end up stranded in the middle of nowhere. They take shelter at the home of an eccentric family, who believe they are married, which causes them to re-assess their relationship. Daphne, Martin and Niles schedule interviews for a nanny, a new physical therapist, and a stripper for Martin's bachelor party, but they confuse which candidate is for which position.
Frasier and Charlotte have one last dinner together before she leaves Seattle for Chicago. Ronnie informs Martin that they booked the wrong date for their wedding, in eight days' time. Frasier and Niles decide that they'll put it all together in time. However, in typical Crane fashion, it's one disaster after another, not the least of which is Eddie eating the rings.
Niles and Daphne take Eddie to the vet to retrieve the rings, but while they're there, Daphne goes into labor. Martin, Ronnie and Frasier meet them in the vet's office, and Frasier marries Ronnie and Martin right there. Back at home, Frasier decides to take the San Francisco job that Bebe had lined up for him, and with Kenny leaving KACL to go back to being a disc jockey, Roz becomes the new station manager. With everyone beginning new chapters in their lives, Frasier finishes recapping his whirlwind three weeks with the lovely woman seated next to him on the plane, ...