When accountant Ernie Pitt abandons Mark on his IRS audit, Mark goes to confront him. Mark is found leaning over Ernie's dead body and is accused of his murder, which means he has to answer to an IRS agent and a homicide detective.
The chairman of the Malone Foundation accuses his board members (including Norman Briggs) of embezzling, and then falls dead from poisoning. As the board members are investigated, they are killed off one by one.
After a public confrontation, Robert Stanton's wife and mistress conspire to kill him and dispose of his body. When Robert fails to show for a medical appointment, Mark convinces Steve to investigate their complicated relationship.
While giving a tour to the hospital accreditation committee, Mark finds a murdered body and tries to keep the committee from seeing it. Solving the murder is problematic, as the body keeps disappearing and all of the suspects have alibis.
Sexy TV star Pamela Dorn sneaks out of the hospital to confront her latest ex-husband, but she finds him murdered. A female reporter gets video of Pamela at the scene of the murder, but Mark believes another ex-husband is the culprit.
Executive William Bissell is murdered through an overdose while in therapy at the hospital. Bissell had several suspects with motives, including his wife, his mistress, his heir apparent, and the surgeon whom he was suing for malpractice.
Jack asks Mark to operate on his godfather, mob boss Alfredo Bartolo, alias Mr. Johnson. Al dies in the recovery room, apparently from sabotaged sutures. His son Vinnie blames Mark and threatens revenge.
Mark overhears a dying private investigator say, "Tell Georgia - Jerry Mathers". His secretary Georgia can't decipher the message, and she joins Steve and Jack to look for the murderous culprit in the Walter and Harry Ice Cream Company.
Norman insists Mark should ask rich plastic surgeon colleague Dr. Elliott Valin, when he's named "Doctor of the Year" at a medical convention, to bring some 'high profile clientele' to Community General, a suggestion Valin rudely dismisses. When Valin dies from an overdose of laughing gas, Mark investigates. Valin's son Roger Valin found out his father was also fooling around with his girlfriend and needed money to prevent his holistic medicine practice from going belly up. Yet the victim's much younger widow Bonnie, who has a hunky lover is accused, convinces Mark to...
After a court exonerates Bonnie Valin for her husband's murder, Mark learns that her alibi is fabricated. Mark strives to get her convicted without incurring double jeopardy. Meanwhile, Jack helps Amanda recover her swindled fortune.
Mark's obnoxious sister Dora moves in with him while her new house is fumigated. When her Realtor's dead body is found in the house, Mark is frantic to solve the murder so Dora can move into her new house.
Boxer Tommy Bracket is found dead after knocking out champion Mercury Jones and refusing a rematch. Evidence points to Mercury as the killer, but Mark finds that his wife, a corrupt promoter, and a bankrupt gym owner also have motives.
Jack is honored as one of L.A.'s most eligible bachelors, but the honorees are being killed one after the other with vampire-like symptoms. Mark must solve the string of murders before Jack becomes the next victim.
A television show is being filmed at the hospital and Mark keeps interrupting the filming due to their inaccuracies. When the lead actor is murdered, Mark investigates everyone as the actor was unpopular among the cast.
When a good friend apparently commits suicide, Mark investigates a series of suicides associated with the Perfect Couple dating service. To aid in the investigation, Jack joins the dating service as an eligible bachelor.
Paroled murderer Eddie Gault takes a low-paying job at Community General to get close to Mark and plot his revenge against Steve for putting him in prison. Steve tries to stop Eddie and gets in trouble for harassing him without evidence.
Norman takes pride in a Community General sponsorship contract with his second cousin's women's volleyball team, the Malibu Rockets. Alas the players do more fighting then teaming, and allegedly an unidentified deranged man is attacking star player Rita Jansen, not a first. The sponsorship includes free physicals, which Norman insist to be done by unwilling 'mature' Mark, not 'young horny' volunteer Jack. Rita is murdered just after a player tampered with the team's blood sample labels, which is found out; Jack will take new ones, chaperoned by Amanda, but finds ...
A woman is swimming in the ocean. Two lifeguards are on duty, but one is sleeping. When the woman is found dead by drowning, the sleeping lifeguard is accused. His aunt, IRS Agent Gretchen McCord, helps Mark with the investigation.
Arnold Baskin, Steve's timid evening law course professor, is suddenly the target of a hit and run. It's prevented by his law firm assistant and most zealous student Agnes Benedetto. At the firm, the commercially vital Orinsky case file Baskin is working on repeatedly disappears and reemerges, making senior partners Wallace Carstairs and Jeffrey T. Canfield warn him that his job is on the line. Steve assures Arnold's protection and investigates, helped by Jack, who once more has painful run-ins, landing him in the emergency room, and ultimately coached to the solution...
Amanda surprised the gang plus Norman by hosting a dinner party, when her high-pregnant friend Angela Pearson arrives and gives birth to healthy quadruplets - two boys and two girls, while insisting (apparently deliriously) not to let the babies be stolen. This apparently has something to do with her friend Carol at Shady Glen, a well-reputed home Amanda recommended herself. The hospital colleagues are literally left holding the babies, a task soon ceasing to be cute. Angela goes missing next morning, so the quadruplets, claimed as publicity boon for Comunity General ...
In a raffle, Amanda won a 'walk-on' guest appearance on the soap The Young and the Restless. Everybody is eager to join, only Norman fears it's bad publicity for the hospital. On the set, several accidents and the almost usual threats among the fan-mail clearly add up to a murderer on the lose. Mark becomes a regular, like Steve who does the official investigation, especially after a death, and the Sloans have plenty of suspects to eliminate, both there and outside. It also turns out Amanda looks like an actress on the same show, which is probably why she got attacked...
Psychiatrist Max Frye asks Mark's help convincing his patient, Tara Sampson, that she isn't pregnant from an 'overwhelming alien', if at all. Her husband, rock star Noble Samson, is both unfaithful and abusive, his latest conquest being his band guitarist Willy's gullible wife. During a concert attended by Mark's gang, Noble collapses while entering on stage, with a fatal kitchen-knife is his back. Groupie Christie Rowan was seen leaving Noble's dressing-room. Steve is convinced the case is simple as the Sampsons's maid Anita Henry heard Tara threaten to kill Noble ...