While adrift at sea, the Warners find a message, or rather, a "Moosage in a Bottle." Next, Plotz needs some quick cash to keep the studio solvent, so he loans the Warners to other cartoon studios, where they wreak havoc in badly animated cartoons.
First, a mysterious "It" chases Wakko through the house. In a musical interlude, "Dot - The Macadamia Nut," the Animaniacs dance while Yakko and Wakko sing backup for Dot in a parody of MTV's "The Macarena" video. The last cartoon, "Bully For Skippy," features Skippy Squirrel confronting a school bully just as Slappy becomes the target of a Congressional hearing on TV violence.
In a wacky version of the Snow White story, "Cute First (Ask Questions Later)," Snow White discovers that Dot is the cutest in the land. Next, in the "Friends" parody "Acquaintances," the Warners arrive in New York as immigrants and live in a trendy sitcom apartment. Following this adventure, the Warners take a humorous look at Attila the Hun (to the tune of "Old Dan Tucker") in "Here Comes Attilla." In the final cartoon, Chicken Boo is disguised as the "Boo Wonder," Batman's young sidekick.
It's "Magic Time" when Yakko, Wakko and Dot visit Las Vegas and attend a Schnitzel and Floyd magic show. Next, in "Brain's Apprentice," Pinky and The Brain create little robots to hypnotize the U.S. President and force him to resign.
The regular morning commute becomes chaotic when three squirmy siblings join "The Carpool." Later, in "Sunshine Squirrels," Slappy Squirrel reunites with her old wisecracking acting partner, Suzy Squirrel, and the two become a big success on network television.
Slappy Squirrel awakens to find that her tree house is now "The Christmas Tree" at "Rockyfellow" Center. Then, in "Punchline (Chicken Part 1)," the entire cast of "Animaniacs" appears on the television news program "Punchline."
When regular musical director Richard Stone is off for the day, pompous guest conductor Neivel Nosenest attempts to lead the "Animaniacs" cast in "The Scoring Session" for their latest cartoon. Then, to celebrate their 99th episode, the Warners present "The Animaniacs Suite," a merry montage of clips from the past 98 shows featuring a rousing Richard Stone score.