By the end of the show's run, only nine of the thirteen members of John Bly's gang were shown to be apprehended or killed. They were: Big Smith, Jack Randolph, Brett Bones, Blackbeard LaCutte, Juno Dawkins, Doc McCoy, Ned Zed, Pepe Bendix, and Bly himself. The remaining four gang members are unaccounted for, although it is implied that they were captured at some point before The Adventures of Brisco County Jr.: Bye Bly (1994), based on dialog between Brisco and Bowler where they mention that Pepe Bendix is the last remaining gang member.
Bruce Campbell cited Brisco County Jr. as his favorite role. On the special DVD featurette he commented "it was the most exhausting, physically demanding year of my life. It was also the best." The other cast members all shared similar sentiments.
Bruce Campbell did a standing back flip during his audition. His reasoning was that because the show would be very action-packed, he wanted to impress the producers with his ability and willingness to handle himself physically.
Though the show only lasted one season, the series' majestic theme song composed by Randy Edelman found a new life as part of NBC's sports productions, namely during NBC broadcasts of the World Series and the Olympic Games (played while announcing the upcoming events).
Was the last production to film on the Laramie Street backlot set at Warner Brothers Studios. It was actually being torn down to accommodate a post-production sound facility during filming of the show, which was used to rerecord the sound for episodes whose audio tracks were disrupted by the construction of said facility.
In the Special Features DVD, writer Carlton Cuse said that when coming up with ideas for the series, he was studying various B-movies from the 50s and 60s, and noticed that many of them were Westerns or Sci-Fis. Cuse then decided to create the series as a combination of the two, creating it as a Western, but with sci-fi elements.
The pilot episode The Adventures of Brisco County Jr.: Pilot (1993) featured a reporter named Jonah Collier who was played by Dan Gerrity. Collier was originally supposed to be a recurring character who would provide plot explanation at the beginning of episodes while covering news stories. The character was removed because the producers decided that the presence of Socrates Poole and his role as a provider of plot exposition made Jonah Collier unnecessary.
Dixie Cousins was originally supposed to be a one-time character, with Professor Wickwire's daughter Amanda (from The Adventures of Brisco County Jr.: Pilot (1993)) serving as Brisco's recurring love interest. However, due to the popularity of Dixie - as well as the great chemistry between Bruce Campbell and Kelly Rutherford - Dixie became a regularly recurring character, while Amanda is never seen again despite her father's importance in Brisco's missions.
Brisco's horse was billed in the credits as "Comet the Wonder Horse," and named Comet in the show, with the implication that he was the smartest character on the show. In fact, "Comet" was actually portrayed by four separate horses, with the horse being used in any particular scene depending on the type of action Comet was expected to perform.
According to writer Carlton Cuse, had the series been renewed for a second season, the main plot line would have centered around Brisco County Jr. eventually settling down, marrying Dixie Cousins, and becoming a sheriff to a town populated by all sorts of characters with similar characteristics to many of the guest characters from Season One.