One particular device that Chevy Chase had to wear for the film was a set of blue, eyeball-sized, contact lenses, so his eyes would appear invisible with his face looking like a mask, but with empty eye sockets. To wear them, his eyes first had to be numbed with sedative medication. The lenses had special miniature pinholes so Chase could see through them. However, after about fifteen minutes of wearing them, Chase said they gave him a headache.
According to "Variety", the "film departs from past explorations of the subject in two specific areas: the hero's clothes are rendered invisible as well, meaning he doesn't have to run about in the nude like cinematic predecessor Claude Rains, and anything he ingests stays visible within him, creating the rare opportunity at one point to see an invisible man upchuck."
This was John Carpenter's first film during the 1990s, and also his first major studio film since Big Trouble in Little China (1986). The reason he'd had not done one, was due to the fact that he'd received a lot of studio interference on that film, and felt restrained to do the films he would've liked independently. Prince of Darkness (1987) and They Live (1988) were made during that time independently.
William Goldman originally wrote several drafts of the screenplay, all of which were rejected, as he wrote it as a simple comedy, and the producers preferred to use the film to "explore the loneliness of invisibility". Eventually, he left the project, though he still receives a screenplay credit. He claims never to have seen the movie, and thus cannot say for sure how much of his material is actually in the film.
The title was not prefixed by the words "John Carpenter's", which had been the Director's practice for some time. Carpenter withdrew his next-to-the-title credit of co-titling the film with his name as "John Carpenter's" because Carpenter knew Warner Brothers would not agree to it. According to the story "John Carpenter: Prince of Darkness" by Bill Chambers at Film Freak Central, Warner Brothers would not allow Carpenter full artistic control, Carpenter saying that the studio "is in the business of making audience-friendly, non-challenging movies."