This alters later scenes taken from the novel, such as when Mina asks Dracula to turn her into a vampire, and willingly drinks his blood. In the novel, Dracula forces Mina to drink his blood, and she is traumatized by the incident.
- In the novel, Dracula immediately dies and crumbles into dust after suffering the knife attacks by Harker and Morris. In the film, he lives for several minutes after the attacks, and Mina delivers the final death blow.
- In the film, Van Helsing asks Mina for permission to hypnotize her, while in the novel it's Mina's idea, and she asks Van Helsing to do it.
- In the film, Mina seduces Van Helsing and attacks him. This does not happen in the novel.
- In the film, Van Helsing presses a communion wafer against Mina's forehead to defend himself against her attack, while in the novel, he does this to bless her, and does not know it will burn her.
- In the film, Dracula transforms into large werewolf and bat creatures, while in the novel, he only transforms into a regular wolf and bat. He also is not explicitly shown to have had sex with Lucy, as in the film.
- In the film, when Dracula is caught with Mina in her room, Jonathan comes into the room with the rest of the men. In the novel, Jonathan is also present with Mina when the men come into the room, lying in a stupor, unable to move, due to Dracula's hypnotic power over him.
- In the film, Dracula escapes Mina's room by turning into mist and going under the closed door, while in the novel, he turns into a hoard of rats and they scurry away.
In the novel, he turns into rats at Carfax Abbey while the men are destroying and sanitizing the crates of soil.
- In the film, Dracula transforms into a wolf and leaps into Lucy's room and attacks her. In the novel's version of this scene, the wolf is not Dracula, but a wolf escaped from the zoo that's under Dracula's hypnotic control, and it does not attack Lucy. In the film, the escaped wolf appears when Dracula and Mina are at the cinema house, a scene not present in the novel.
- In the film, Dracula's brides call Harker into the room with the bed, and when he lies down on it, they appear to rise up from beneath it, and they attack him before Dracula appears and scolds them. In the novel, Harker awakens from sleep on a sofa, and sees the brides standing before him, and Dracula appears before they have a chance to attack him. The brides also appear semi-nude in the film, while in the novel they do not.
- In the film, Renfield is shown to be Harker's predecessor, and it's implied that his experience at Dracula's castle drove him insane, while in the novel, Harker and Renfield are unrelated, and Renfield's insanity is not implied to have been caused by Dracula.
- In the novel, none of the gypsies carrying Dracula to his castle are shot or killed.
- In the film, the blue flame is seen directly in front of Dracula's castle, while in the novel, it's seen in the distance on the journey to the castle. The flame appears again later in the film, though only the one time in the novel.