The Real World heads back to Las Vegas and the seven strangers move into the Hard Rock Hotel. Sparks instantly fly between the roommates and during a drinking game they begin to learn some interesting things about one another.
Dustin falls for Heather, but things get rocky when she kisses another roommate. Adam's out-of-control behavior makes Nany question her feelings for him, and makes the others question whether he belongs in the suite at all.
Adam refuses to explain or apologize for his erratic behavior, but when he overhears them talking trash behind his back, he and Leroy have it out. The roommates start their job, and Naomi learns manual labor isn't her forte.
Nany finds it increasingly difficult to resist Adam, and realizes she has to make a decision soon. And the guys are growing tired of Dustin's constant agonizing about Heather. Leroy and Naomi finally hook up.
Nany's search for a guy takes her on an emotional roller coaster ride with Adam, who shows his feelings for her by destroying the suite in a drunken rant. While the others try to intervene, they know Adam is a ticking time bomb.
Leroy reaches his breaking point with Adam, who has no remorse about trashing the suite. Nany admits her true feelings for Adam, but it might be too late for her to do anything about it. Mike tries to become a playa.
Sam and Nate pull an alarming prank on the other roomies, while sparks begin to fly between Zach and Ashley. And during a night of drinking, Frank becomes belligerent and has to deal with the aftermath the next day.
Tension among the roommates is high after Frank brings a guy home and hooks up all over the house. But that is nothing compared to what happens the next night, when an explosion may send a roommate packing.
Sam receives bad news from home and Zach makes an offensive comment that causes a rift in the house. Zach and Ashley grow closer over trips to the spa and the gun range, and the roomies start their jobs at The House of Blues.
With Zach and Ashley's birthdays approaching, the rest of the house wonders why they are not having sex, and Sam's meddling causes Zach to blow up. And Priscilla's first love, who left her heart broken, re-enters her life.
While Priscilla struggles to define the relationship with her ex, the rest of the roomies play a prank on him that's all fun and games until the police get involved. Alex performs in public for the first time.
Alex sets up a surprise visit from Frank's boyfriend and ---with Frank spending the night out with another guy---the timing couldn't be any worse. Nate's romantic relationship with his boss revs up and burns out just as fast.
When the roommates go camping, Zach and Ashley isolate themselves again. Later, Frank confronts Ashley about her unwillingness to open up and then explodes at Nate for not having his back in the confrontation.
On a trip to Cabo San Lucas, Priscilla gets wild and comes on to Nate, who is busy being terrified of the wildlife around him. Meanwhile, Ashley and Zach isolate themselves leading Frank to blow up on them--again.
In the season finale, the roommates say goodbye to San Diego. But first, Nate gets drunk at his and Frank's charity event, leading to another blowup, and Zach and Ashley must decide the status of their relationship.